Descripción del proyecto
Una investigación multidisciplinar sobre enfermedades vasculares
Las anomalías vasculares (AV o VA, por sus siglas en inglés) son enfermedades raras que causan dolor crónico, discapacidades e, incluso, muerte súbita, y carecen de tratamientos eficaces. El equipo del proyecto V.A. Cure, financiado con fondos europeos, pretende descubrir los mecanismos de inicio y mantenimiento de la enfermedad y utilizar esta información para establecer nuevas estrategias terapéuticas. El consorcio está formado por siete laboratorios académicos líderes en el mundo y cinco empresas. El equipo del proyecto identificará nuevos genes implicados en las AV en los pacientes, analizará los mecanismos moleculares que subyacen a las enfermedades mediante modelos «in vitro», realizará un análisis en profundidad de los mecanismos tisulares en condiciones fisiopatológicas mediante modelos «in vivo» y hará ensayos preclínicos de las estrategias de tratamiento identificadas. V.A. Cure formará a catorce investigadores noveles en varias tecnologías avanzadas y los convertirá en futuros líderes de la investigación vascular.
Objetivo
Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs.
V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases.
The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
1200 Bruxelles / Brussel
Bélgica