Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Project Information

GIOTTO

Grant agreement ID: 814410

DOI 10.3030/814410

Project closed

EC signature date 12 December 2018

Start date 1 January 2019

End date 31 August 2023

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Total cost € 5 660 096,25

EU contribution € 5 660 096,25

Coordinated by

POLITECNICO DI TORINO
Italy

Deliverables

Websites, patent fillings, videos etc. (6)

Project Website

Project Website designed and created

Final Workshop Conference
Pitch presentations

Pitch presentations will be realised by the industrial partners to communicate GIOTTO innovation and to attract potential investors

Final project video

Final project video delivered

Release of two videos targeting scientific and non-scientific audience respectively

Release of two videos targeting scientific and nonscientific audience respectively

Project Communication KIT: graphic identity (Logo), leaflet, press release and poster

Preparation of the Project Communication KIT: graphic identity (Logo), leaflet, press release and poster

Documents, reports (15)

Clinical specifications manual completed
Report on strategy for ethical best practice

1st report on strategy for ethical best practice

Integration of SPIONs for remote control (proof of feasibility)

Strategies for the integration of SPIONs into the devices for remote control

Report update on ethical best practice and 3Rs

2nd report on strategy for ethical best practise

Initial LCA assessment and cost analysis for materials and first prototypes
In vitro assessment of SPIONs and SPION integrated devices

Report on the in vitro assessment of SPIONs and SPION integrated devices

Updated best-in-class benchmarking for GIOTTO devices
Recombinant ICOS-Fc molecules for pre-clinical test developed

Development of recombinant ICOSFc molecules for preclinical test

Multiscale models developed

Development of the multiscale models

Definition of the in vivo model types and protocols
Development of co-culture test under mechanical stimulation

Development of a coculture cellular test under mechanical stimulation

Best-in-class benchmarking for GIOTTO solution competitors

First report on bestinclass benchmarking for GIOTTO solution competitors

Report on material biocompatibility
Final report on ethical best practice

3rd report on strategy for ethical best practice

Development of novel ligands for ICOS-Fc to be used in humans

Open Research Data Pilot (1)

Data Management plan and VDBs

Data Management plan and multiple Virtual Databases

Demonstrators, pilots, prototypes (4)

Data on boarding scripts and applets
Patient progress tracking and management platform

Platform for tracking and management of patient progress

Sensor integration for in vivo tests
Data analytics and result correlation platform

Publications

Peer reviewed articles (25)

Large-scale production of superparamagnetic iron oxide nanoparticles by flame spray pyrolysis: In vitro biological evaluation for biomedical applications

Author(s): Manuel Estévez Mónica Cicuéndez, Julián Crespo, Juana Serrano-López, Montserrat Colilla, Claudio Fernández-Acevedo, Tamara Oroz-Mateo, Amaia Rada-Leza, Blanca González , Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Journal of Colloid and Interface Science, 2023, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2023.07.009

Sr-Containing Mesoporous Bioactive Glasses Bio-Functionalized with Recombinant ICOS-Fc: An In Vitro Study

Author(s): Sonia Fiorilli, Mattia Pagani, Elena Boggio, Casimiro Luca Gigliotti, Chiara Dianzani, Rémy Gauthier, Carlotta Pontremoli, Giorgia Montalbano, Umberto Dianzani and Chiara Vitale-Brovarone
Published in: Nanomaterials, Issue Volume 11 Issue 2, 321 27 January 2021, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11020321

A computational analysis of a novel therapeutic approach combining an advanced medicinal therapeutic device and a fracture fixation assembly for the treatment of osteoporotic fractures: Effects of physiological loading, interface conditions, and fracture fixation materials

Author(s): Subrata Mondala, David B. MacManus, Amedeo Franco Bonatti, Carmelo De Maria,k, Kenny Dalgarno, Maria Chatzinikolaidou, Aurora De Acutis, Giovanni Vozzi,Sonia Fiorilli, Chiara Vitale-Brovarone, Nicholas Dunne
Published in: Medical engineering & Physics, 2023, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2023.103967

Incorporation of Superparamagnetic Iron Oxide Nanoparticles into Collagen Formulation for 3D Electrospun Scaffolds

Author(s): Estévez, M., Montalbano, G., Gallo-Cordova, A., Ovejero, J. G., Izquierdo-Barba, I., González, B., Tomasina, C., Moroni, L., Vallet-Regi, M., Vitale-Brovarone, C., Fiorilli, S.
Published in: Nanomaterials, 2022, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12020181

Osteogenic Potential of Nano-Hydroxyapatite and Strontium-Substituted Nano-Hydroxyapatite

Author(s): Georgia-Ioanna Kontogianni,Catarina Coelho,Rémy Gauthier,Sonia Fiorilli,Paulo Quadros,Chiara Vitale-Brovarone and Maria Chatzinikolaidou
Published in: Nanomaterials, 2023, ISSN 1687-4129
Publisher: MDPI
DOI: 10.3390/nano13121881

The Role of Machine Learning and Design of Experiments in the Advancement of Biomaterial and Tissue Engineering Research

Author(s): Ghayadah Al-Kharusi,Nicholas J. Dunne,Suzanne Little and Tanya J. Levingstone
Published in: Bioengineering, 2023, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering9100561

Influence of PCL and PHBV on PLLA Thermal and Mechanical Properties in Binary and Ternary Polymer Blends

Author(s): Raasti Naseem; Giorgia Montalbano; Matthew J. German; Ana M. Ferreira; Piergiorgio Gentile; Kenneth Dalgarno
Published in: Molecules; Volume 27; Issue 21; Pages: 7633, Issue 17, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27217633

Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures

Author(s): Federica Banche-Niclot; Ilaria Corvaglia; Caterina Cavalera; Elena Boggio; Casimiro Luca Gigliotti; Umberto Dianzani; Antzela Tzagiollari; Nicholas Dunne; Antonio Manca; Sonia Fiorilli; Chiara Vitale-Brovarone
Published in: Biomolecules, Issue 6, 2023, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13010094

Nanocomposite Bioprinting for Tissue Engineering Applications

Author(s): Konstantinos Loukelis; Zina A. Helal; Antonios G. Mikos; Maria Chatzinikolaidou
Published in: Gels, Issue 2, 2023, ISSN 2310-2861
Publisher: MDPI
DOI: 10.3390/gels9020103

Structure-activity relationship for antibacterial chitosan carrying cationic and hydrophobic moieties

Author(s): Priyanka Sahariah; Georgia-Ioanna Kontogianni; Effie Scoulica; Olafur E. Sigurjonsson; Maria Chatzinikolaidou
Published in: Carbohydrate Polymers, Issue 5, 2023, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2023.120796

A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

Author(s): Elisa Batoni; Amedeo Franco Bonatti; Carmelo De Maria; Kenneth Dalgarno; Raasti Naseem; Umberto Dianzani; Casimiro Luca Gigliotti; Elena Boggio; Giovanni Vozzi
Published in: Volume 15, Issue 19, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15030815

Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

Author(s): E. Alvarez, M. Estevez, A. Gallo-Cordova, B. Gonzalez, R. Castillo, MP. Morales, M. Colilla, I. Izquierdo-Barba, M. Vallet-Regi
Published in: PHARMACEUTICS, Issue Volume 14 article number 163 (2022), 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010163

Strategies for Enhancing Polyester-Based Materials for Bone Fixation Applications

Author(s): Naseem, R; Tzivelekis, C; German, MJ; Gentile, P; Ferreira-Duarte, A & Dalgarno K.
Published in: Molecules, Issue Molecules 2021, 26(4), 992, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26040992

Promotion of In Vitro Osteogenic Activity by Melt Extrusion-Based PLLA/PCL/PHBV Scaffolds Enriched with Nano-Hydroxyapatite and Strontium Substituted Nano-Hydroxyapatite

Author(s): Georgia-Ioanna Kontogianni; Amedeo Franco Bonatti; Carmelo De Maria; Raasti Naseem; Priscila Melo; Catarina Coelho; Giovanni Vozzi; Kenneth Dalgarno; Paulo Quadros; Chiara Vitale-Brovarone; Maria Chatzinikolaidou
Published in: Polymers, Issue 1, 2023, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym15041052

Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds

Author(s): Priscila Melo, Raasti Naseem, Ilaria Corvaglia, Giorgia Montalbano, Carlotta Pontremoli, António Azevedo, Paulo Quadros, Piergiorgio Gentile, Ana Marina Ferreira, Kenneth Dalgarno, Chiara Vitale-Brovarone, and Sonia Fiorilli
Published in: Frontiers in Materials, 2020, ISSN 2296-8016
Publisher: Frontiers
DOI: 10.3389/fmats.2020.601645

Electrospun Collagen Scaffold Bio-Functionalized with Recombinant ICOS-Fc: An Advanced Approach to Promote Bone Remodelling

Author(s): Priscila Melo; Giorgia Montalbano; Elena Boggio; Casimiro Luca Gigliotti; Chiara Dianzani; Umberto Dianzani; Chiara Vitale-Brovarone; Sonia Fiorilli
Published in: Polymers, Issue 2, 2022, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14183780

A Doubly Fmoc-Protected Aspartic Acid Self-Assembles into Hydrogels Suitable for Bone Tissue Engineering

Author(s): Katerina Petropoulou; Varvara Platania; Maria Chatzinikolaidou; Anna Mitraki
Published in: Materials, Issue 4, 2023, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma15248928

A deep learning approach for error detection and quantification in extrusion-based bioprinting

Author(s): Amedeo Franco Bonatti, Giovanni Vozzi, Chee Kai Chua, Carmelo De Maria
Published in: Materials Today : Proceedings, 2022, ISSN 2214-7853
Publisher: Elsevier
DOI: 10.1016/j.matpr.2022.09.006

A Deep Learning Quality Control Loop of the Extrusion-based Bioprinting Process

Author(s): Amedeo Franco Bonatti, Giovanni Vozzi, Chee Kai Chua, Carmelo De Maria
Published in: International Journal of Bioprinting, 2022, ISSN 2424-8002
Publisher: ACCScience Publishing
DOI: 10.18063/ijb.v8i4.620

Biomimetic Scaffolds Obtained by Electrospinning of Collagen-Based Materials: Strategies to Hinder the Protein Denaturation

Author(s): Giorgia Montalbano , Clarissa Tomasina , Sonia Fiorilli , Sandra Camarero-Espinosa , Chiara Vitale-Brovarone , Lorenzo Moroni 
Published in: Materials, Issue Materials 2021, 14(16), 4360, 2021, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma14164360

Incorporation of strontium-containing bioactive particles into PEOT/PBT electrospun scaffolds for bone tissue regeneration

Author(s): Clarissa Tomasina, Giorgia Montalbano, Sonia Fiorilli, Paulo Quadros, Antonio Azevedo, Catarina Coelho, Chiara Vitale-Brovarone, Sandra Camarero-Espinosa, Lorenzo Moroni
Published in: Biomaterials Advances, 2023, ISSN 2772-9508
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2023.213406

Open-source CAD-CAM simulator of the extrusion-based bioprinting process

Author(s): Amedeo Franco Bonatti, Irene Chiesa, Giovanni Vozzi, Carmelo De Maria
Published in: Bioprinting, Issue Bioprinting 24 (2021) e00172, 2021, ISSN 2405-8866
Publisher: Elsevier
DOI: 10.1016/j.bprint.2021.e00172

Bioprinting Vasculature: Materials, Cells and Emergent Techniques

Author(s): Clarissa Tomasina,Tristan Bodet, Carlos Mota, Lorenzo Moroni, and Sandra Camarero-Espinosa
Published in: Materials, Issue Materials 2019, 12(17), 2701, 2019, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma12172701

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

Author(s): María Vallet-Regí; Montserrat Colilla; Isabel Izquierdo-Barba; Chiara Vitale-Brovarone; Sonia Fiorilli
Published in: Pharmaceutics, Issue 16, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122636

Effect of Uniaxial Compression Frequency on Osteogenic Cell Responses in Dynamic 3D Cultures

Author(s): Georgia-Ioanna Kontogianni; Konstantinos Loukelis; Amedeo Franco Bonatti; Elisa Batoni; Carmelo De Maria; Raasti Naseem; Kenneth Dalgarno; Giovanni Vozzi; David B. MacManus; Subrata Mondal; Nicholas Dunne; Chiara Vitale-Brovarone; Maria Chatzinikolaidou
Published in: Bioengineering, Issue 15, 2023, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering10050532

Other (1)

Editorial: Highlights From TERMIS EU 2019

Author(s): Maria Chatzinikolaidou, and Dimitrios I. Zeugolis
Published in: Frontiers in Bioengineering and Biotechnology, Issue Volume 8, Article 604661, 2020
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.604661