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Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Objective

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing.
The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions:
1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures
2) Fibrous scaffold to deal with small, not confined pelvic fractures;
3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures.
The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

Call for proposal

H2020-NMBP-TR-IND-2018
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

POLITECNICO DI TORINO
Address
Corso Duca Degli Abruzzi 24
10129 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 920 750

Participants (13)

UNIVERSITA DI PISA
Italy
EU contribution
€ 332 000
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 392 490
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 326 047,50
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 375 000
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 362 445
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 355 608,75
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
BEWARRANT
Belgium
EU contribution
€ 324 625
Address
Avenue Henri Jaspar 113
1060 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELLINK AB
Sweden
EU contribution
€ 300 000
Address
Arvid Wallgrens Backe 20
413 46 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMECH INNOVATIONS AG
Switzerland
EU contribution
€ 622 067,50
Address
Aarbergstrasse 5
2560 Nidau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FLUIDINOVA SA
Portugal
EU contribution
€ 237 500
Address
Rua Engenheiro Frederico Ulrich 2650 Tecmaia Parque De Ciencia E Tecnologia Da Maia
4470 605 Maia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL
Spain
EU contribution
€ 263 500
Address
Area Industrial Perguita C/a 1
31210 Los Arcos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVAICOS SRLS
Italy
EU contribution
€ 550 312,50
Address
Via Amico Canobio 4/6
28100 Novara (No)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON
Greece
EU contribution
€ 297 750
Address
E O Ano Kato Kastritsiou 4
26504 Rio Patras
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)