Project description DEENESFRITPL Stem cell technology to promote endoprosthesis osseointegration Revision endoprosthesis is often complicated by severe inflammatory post-surgical reactions in the endoprosthesis area, leading to long-term immobility and, in severe cases, implant rejection. The EU-funded EVPRO project will work on integrating multidisciplinary technologies to promote successful osseointegration of endoprostheses in osteoarticular tissue regeneration. The project will employ human mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which suppress inflammatory reactions and display pro-regenerative properties in osteogenic applications. The MSC-EVs will be delivered directly to the site of inflammation and affix to the implant surface, where they will exert their anti-inflammatory and regenerative effects in response to the local inflammation. Researchers aim to achieve this by integrating the MSC-EVs in biodegradable hydrogel absorbed into the micropores of a conventional titanium endoprosthesis. Show the project objective Hide the project objective Objective Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection. Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis. Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human mesenchymal stem cell derived extracellular vesicles (MSC-EVs) which are known to suppress inflammatory reaction in humans, exert pro-regenerative effects in osteogenic setting and successfully treat patients with steroid-refractory graft-versus-host disease. In this project the MSC-EVs will be applied in direct physical proximity to the site of inflammation and will therefore affix on the implant surface to deliver their anti-inflammatory and regenerative effect in response to the local inflammation status. This will be achieved by safe integration of the MSC-EVs in a smart biodegradable hydrogel that is absorbed into the micropores of a TiO2 coating on the surface of conventional titan endoprosthesis. EVPRO enables the progression of each individual technology, along with EVPRO system level integration developments, into pre-clinical trials, this means in detail, the development of a GMP conformed large scale production of MSC-EVs, the establishing of an uniform method to purify and select the most potential MSC-EVs with a microfluidic system and the design of a self-regulated hydrogel as protection matrix of MSC-EVs with the function to store and release MSC-EVs in response to the inflammation status, The EVPRO project is an integration of multidisciplinary post-proof of concept technologies which enables the successful resolution of the enhanced osseointegration of endoprosthesis for osteoarticular tissue regeneration. Fields of science natural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesclinical medicineemergency medicinegraft versus host diseasemedical and health sciencesmedical biotechnologyimplants Keywords mesenchymal-derived extracellular vesicles Revision endoprosthesis hydrogel Inflammation TiO2-surface coating Programme(s) H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials Main Programme H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Topic(s) NMBP-22-2018 - Osteoarticular tissues regeneration (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-TR-IND-2018 Funding Scheme RIA - Research and Innovation action Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Net EU contribution € 865 646,25 Address Hansastrasse 27c 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAETSKLINIKUM ESSEN Germany Net EU contribution € 603 250,00 Address Hufelandstrasse 55 45147 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LONZA NETHERLANDS BV Netherlands Net EU contribution € 399 475,00 Address Oxfordlaan 70 6229 EV Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. LONZA COLOGNE GMBH Germany Net EU contribution € 12 500,00 Address Nattermannallee 1 50829 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DUBLIN CITY UNIVERSITY Ireland Net EU contribution € 569 070,00 Address Glasnevin 9 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Ireland Net EU contribution € 438 327,50 Address College green trinity college D02 CX56 Dublin 2 See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV Germany Net EU contribution € 526 080,00 Address Forckenbeckstrasse 50 52074 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT MAASTRICHT Netherlands Net EU contribution € 509 363,75 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEOTEC GMBH Germany Net EU contribution € 511 250,00 Address Philipsstrasse 8 52068 Aachen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STRYKER EUROPEAN OPERATIONS BV Netherlands Net EU contribution € 313 750,00 Address Herikerbergweg 110 1101 CM Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. STRYKER GMBH & CO. KG Germany Net EU contribution € 80 000,00 Address Dr. homer-stryker-platz 1 47228 Duisburg See on map Region Nordrhein-Westfalen Düsseldorf Duisburg, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 POLITECNICO DI TORINO Italy Net EU contribution € 500 000,00 Address Corso duca degli abruzzi 24 10129 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH Germany Net EU contribution € 470 376,25 Address In der schornau 23 25 44892 Bochum See on map Region Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
