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EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Project description

Stem cell technology to promote endoprosthesis osseointegration

Revision endoprosthesis is often complicated by severe inflammatory post-surgical reactions in the endoprosthesis area, leading to long-term immobility and, in severe cases, implant rejection. The EU-funded EVPRO project will work on integrating multidisciplinary technologies to promote successful osseointegration of endoprostheses in osteoarticular tissue regeneration. The project will employ human mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which suppress inflammatory reactions and display pro-regenerative properties in osteogenic applications. The MSC-EVs will be delivered directly to the site of inflammation and affix to the implant surface, where they will exert their anti-inflammatory and regenerative effects in response to the local inflammation. Researchers aim to achieve this by integrating the MSC-EVs in biodegradable hydrogel absorbed into the micropores of a conventional titanium endoprosthesis.

Call for proposal

H2020-NMBP-TR-IND-2018-2020

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Sub call

H2020-NMBP-TR-IND-2018

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Net EU contribution
€ 865 646,25
Address
Hansastrasse 27c
80686 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00

Participants (12)

UNIVERSITAETSKLINIKUM ESSEN
Germany
Net EU contribution
€ 603 250,00
Address
Hufelandstrasse 55
45147 Essen

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Region
Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
LONZA NETHERLANDS BV
Netherlands
Net EU contribution
€ 399 475,00
Address
Oxfordlaan 70
6229 EV Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

LONZA COLOGNE GMBH
Germany
Net EU contribution
€ 12 500,00
Address
Nattermannallee 1
50829 Koln

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Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
DUBLIN CITY UNIVERSITY
Ireland
Net EU contribution
€ 569 070,00
Address
Glasnevin
9 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 438 327,50
Address
College Green Trinity College
D02 CX56 Dublin 2

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
Germany
Net EU contribution
€ 526 080,00
Address
Forckenbeckstrasse 50
52074 Aachen

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 509 363,75
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MEOTEC GMBH
Germany
Net EU contribution
€ 511 250,00
Address
Philipsstrasse 8
52068 Aachen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STRYKER EUROPEAN OPERATIONS BV
Netherlands
Net EU contribution
€ 313 750,00
Address
Herikerbergweg 110
1101 CM Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

STRYKER GMBH & CO. KG
Germany
Net EU contribution
€ 80 000,00
Address
Dr. Homer-stryker-platz 1
47228 Duisburg

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Region
Nordrhein-Westfalen Düsseldorf Duisburg, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
POLITECNICO DI TORINO
Italy
Net EU contribution
€ 500 000,00
Address
Corso Duca Degli Abruzzi 24
10129 Torino

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH
Germany
Net EU contribution
€ 470 376,25
Address
In Der Schornau 23 25
44892 Bochum

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Region
Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00