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EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Objective

Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection. Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis. Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human mesenchymal stem cell derived extracellular vesicles (MSC-EVs) which are known to suppress inflammatory reaction in humans, exert pro-regenerative effects in osteogenic setting and successfully treat patients with steroid-refractory graft-versus-host disease. In this project the MSC-EVs will be applied in direct physical proximity to the site of inflammation and will therefore affix on the implant surface to deliver their anti-inflammatory and regenerative effect in response to the local inflammation status. This will be achieved by safe integration of the MSC-EVs in a smart biodegradable hydrogel that is absorbed into the micropores of a TiO2 coating on the surface of conventional titan endoprosthesis. EVPRO enables the progression of each individual technology, along with EVPRO system level integration developments, into pre-clinical trials, this means in detail, the development of a GMP conformed large scale production of MSC-EVs, the establishing of an uniform method to purify and select the most potential MSC-EVs with a microfluidic system and the design of a self-regulated hydrogel as protection matrix of MSC-EVs with the function to store and release MSC-EVs in response to the inflammation status,
The EVPRO project is an integration of multidisciplinary post-proof of concept technologies which enables the successful resolution of the enhanced osseointegration of endoprosthesis for osteoarticular tissue regeneration.

Field of science

  • /engineering and technology/materials engineering/coating and films
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/emergency medicine/graft versus host disease

Call for proposal

H2020-NMBP-TR-IND-2018
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 865 646,25

Participants (10)

UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 603 250
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
LONZA NETHERLANDS BV
Netherlands
EU contribution
€ 411 975
Address
Oxfordlaan 70
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 569 070
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 438 327,50
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
Germany
EU contribution
€ 526 080
Address
Forckenbeckstrasse 50
52074 Aachen
Activity type
Research Organisations
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 509 363,75
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
MEOTEC GMBH
Germany
EU contribution
€ 511 250
Address
Philipsstrasse 8
52068 Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STRYKER EUROPEAN OPERATIONS BV
Netherlands
EU contribution
€ 393 750
Address
Herikerbergweg 110
1101 CM Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
POLITECNICO DI TORINO
Italy
EU contribution
€ 500 000
Address
Corso Duca Degli Abruzzi 24
10129 Torino
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH
Germany
EU contribution
€ 470 376,25
Address
In Der Schornau 23 25
44892 Bochum
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)