EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Project Information

EVPRO

Grant agreement ID: 814495

DOI 10.3030/814495

Project closed

EC signature date 14 December 2018

Start date 1 January 2019

End date 30 November 2023

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Total cost € 5 799 088,75

EU contribution € 5 799 088,75

Coordinated by

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

Deliverables

Documents, reports (1)

Dissemination and Communication Plan

This is targets a broad audience and the highest possible impact. For this reason, the dissemination of the developed concept includes newsletters, papers on scientific and technical journals and conferences and the creation and management of a website and the respective forum in social media.

Websites, patent fillings, videos etc. (1)

Project website, Twitter, Facebook

Coordinate the dissemination of project results to targeted audiences with the use of adequate sets of mediaThe purpose of the website is to make project developments visible in a timely manner; the forum will be used for discussions to get direct feedback of external stakeholders

Publications

Peer reviewed articles (6)

Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers

Author(s): Qi Xiao, Martina Delbianco, Samuel E. Sherman, Aracelee M. Reveron Perez, Priya Bharate, Alonso Pardo-Vargas, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Khosrow Rahimi, Dominik Söder, Martin Möller, Michael L. Klein, Peter H. Seeberger, Virgil Percec
Published in: Proceedings of the National Academy of Sciences, Issue 117/22, 2020, Page(s) 11931-11939, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2003938117

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications

Author(s): Dimitrios Tsiapalis, Lorraine O’Driscoll
Published in: Cells, Issue 9/4, 2020, Page(s) 991, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells9040991

Unraveling topology-induced shape transformations in dendrimersomes

Author(s): Nina Yu. Kostina, Anna M. Wagner, Tamás Haraszti, Khosrow Rahimi, Qi Xiao, Michael L. Klein, Virgil Percec, Cesar Rodriguez-Emmenegger
Published in: Soft Matter, 2020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm01097a

Photoinduced Upgrading of Lactic Acid-Based Solvents to Block Copolymer Surfactants

Author(s): Nabil Bensabeh, Adrian Moreno, Adrià Roig, Mehrnoush Rahimzadeh, Khosrow Rahimi, Juan Carlos Ronda, Virginia Cádiz, Marina Galià, Virgil Percec, Cesar Rodriguez-Emmenegger, Gerard Lligadas
Published in: ACS Sustainable Chemistry & Engineering, Issue 8/2, 2019, Page(s) 1276-1284, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.9b06599

Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms

Author(s): Shangda Li, Boao Xia, Bilal Javed, William D. Hasley, Adriel Melendez-Davila, Matthew Liu, Meir Kerzner, Shriya Agarwal, Qi Xiao, Paola Torre, Jessica G. Bermudez, Khosrow Rahimi, Nina Yu. Kostina, Martin Möller, Cesar Rodriguez-Emmenegger, Michael L. Klein, Virgil Percec, Matthew C. Good
Published in: ACS Nano, Issue 14/6, 2020, Page(s) 7398-7411, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c02912

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

Author(s): Paola Torre, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu. Kostina, Cesar Rodriguez-Emmenegger, Martin Möller, Christopher J. Wilson, Michael L. Klein, Matthew C. Good, Virgil Percec
Published in: Proceedings of the National Academy of Sciences, Issue 116/31, 2019, Page(s) 15378-15385, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1904868116