Project description DEENESFRITPL Nanotechnology could slow the progression of osteoarthritis Untreated or insufficiently treated chondral lesions will most likely progress to osteoarthritis, which affects 242 million people globally. The EU-funded RESTORE project is working on an effective approach to the treatment of knee chondral lesions. Bringing together orthopaedic surgeons, tissue engineers, material scientists, cell biologists and businesses, the project plans to develop a new generation of smart nanoenabled 3D matrices that can fit into complex lesion geometry, modulate undesirable biological events and remotely control, stimulate and monitor cartilage repair. RESTORE will address the shortfalls of current therapeutic solutions, helping prevent or delay the onset of osteoarthritis. Show the project objective Hide the project objective Objective The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing. Fields of science natural sciencesphysical scienceselectromagnetism and electronicselectromagnetismengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsradio technologyradio frequencynatural sciencesmathematicspure mathematicsgeometry Keywords smart nanobiomaterials nano carriers cartilage regeneration chondral lesions bioprinting remote control stimuli-responsive user-centred Programme(s) H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials Main Programme H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Topic(s) NMBP-22-2018 - Osteoarticular tissues regeneration (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-TR-IND-2018 Funding Scheme RIA - Research and Innovation action Coordinator INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA Net EU contribution € 933 243,45 Address Rua alfredo allen 208 4200 135 Porto Portugal See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all OULUN YLIOPISTO Finland Net EU contribution € 918 802,80 Address Pentti kaiteran katu 1 90014 Oulu See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET ULM Germany Net EU contribution € 409 312,50 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HASKOLINN I REYKJAVIK EHF Iceland Net EU contribution € 318 185,00 Address Menntavegur 1 102 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACION CIDETEC Spain Net EU contribution € 554 375,00 Address Paseo miramon 196 parque tecnologico de miramon 20014 San sebastian See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GOETEBORGS UNIVERSITET Participation ended Sweden Net EU contribution € 0,00 Address Vasaparken 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SINTEF AS Norway Net EU contribution € 699 705,00 Address Strindvegen 4 7034 Trondheim See on map Region Norge Trøndelag Trøndelag Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy Net EU contribution € 449 937,50 Address Duomo 6 13100 Vercelli See on map Region Nord-Ovest Piemonte Vercelli Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ASKEL HEALTHCARE OY Finland Net EU contribution € 303 750,00 Address Siltasaarenkatu 8-10 00530 Helsinki See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 3DTECH OY Participation ended Finland Net EU contribution € 194 089,17 Address Hyvoninkatu 1 24240 Salo See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 VÄSTRA GÖTALANDSREGIONEN Sweden Net EU contribution € 553 050,00 Address Regionens hus 462 80 Vanersborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BRINTER OY Finland Net EU contribution € 205 285,83 Address Itainen pitkakatu 4 c 20520 Turku See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00