Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking

Project Information

SUMMIT

Grant agreement ID: 814747

DOI

10.3030/814747

Project closed

EC signature date 6 February 2019

Start date 1 October 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 768,00

EU contribution

€ 1 999 768,00

Coordinated by

NANTES UNIVERSITE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (29)

Hyperpolarized ¹³C NMR Spectroscopy of Urine Samples at Natural Abundance by Quantitative Dissolution Dynamic Nuclear Polarization

Author(s): Victor Ribay; Arnab Dey; Benoît Charrier; Clément Praud; Joris Mandral; Jean‐Nicolas Dumez; Marine P. M. Letertre; Patrick Giraudeau
Published in: Crossref, Issue 6, 2023, Page(s) e202302110, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202302110

Non‐uniform sampling to enhance the performance of compact NMR for characterizing new psychoactive substances

Author(s): Thomas Castaing‐Cordier; Sélina Crasnier; Damien Dubois; Virginie Ladroue; Audrey Buleté; Cédric Prudhomme; Céline Charvoz; Fabrice Besacier; Denis Jacquemin; Patrick Giraudeau; Jonathan Farjon
Published in: Magnetic Resonance in Chemistry, 2024, ISSN 0749-1581
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrc.5416

Clean ¹H NMR Spectra of Products Directly from Batch and Flow Reaction Mixtures

Author(s): Yuliia Horbenko, Martin Jaudronnet, Nour El Sabbagh, Margherita Bazzoni, Aurélie Bernard, Mathias Nilsson, Patrick Giraudeau, François‐Xavier Felpin, Jean‐Nicolas Dumez
Published in: ChemistryEurope, Issue 3, 2025, ISSN 2751-4765
Publisher: Wiley
DOI: 10.1002/ceur.202500038

Hyperpolarized ¹³C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease

Author(s): Victor Ribay, Benoît Charrier, Mikaël Croyal, Bertrand Cariou, Samy Hadjadj, Julien Boccard, Claire Cannet, Jean-Nicolas Dumez, Marine P. M. Letertre, Patrick Giraudeau
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 644-650, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c12607

Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals

Author(s): Anna J. Parker; Arnab Dey; Mohammad Usman Qureshi; Jakob M. Steiner; John W. Blanchard; Jochen Scheuer; Nikolas Tomek; Stephan Knecht; Felix Josten; Christoph Müller; Patrick Hautle; Ilai Schwartz; Patrick Giraudeau; Tim R. Eichhorn; Jean‐Nicolas Dumez
Published in: Crossref, Issue 7, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202312302

Exploring the complementarity of fast multipulse and multidimensional NMR methods for metabolomics: a chemical ecology case study

Author(s): Aurore Michaud, Samuel Bertrand, Serge Akoka, Jonathan Farjon, Estelle Martineau, Nicolas Ruiz, Thibaut Robiou du Pont, Olivier Grovel, Patrick Giraudeau
Published in: Analytical Methods, Issue 16, 2024, Page(s) 5166-5177, ISSN 1759-9660
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4ay01225a

Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation

Author(s): Lucy Botros, Yang Liu, Charlotte Corbett, Dan Sørensen, Christina Szabo, Anton Bzhelyansky, Matthias Niemitz, Petrus Korhonen, Guido F. Pauli, Patrick Giraudeau, G. Joseph Ray
Published in: Journal of Natural Products, Issue 88, 2025, Page(s) 877-888, ISSN 0163-3864
Publisher: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01013

Ultrafast 2D NMR for the analysis of complex mixtures

Author(s): Célia Lhoste, Benjamin Lorandel, Clément Praud, Achille Marchand, Rituraj Mishra, Arnab Dey, Aurélie Bernard, Jean-Nicolas Dumez, Patrick Giraudeau
Published in: Progress in Nuclear Magnetic Resonance Spectroscopy, Issue 130-131, 2022, Page(s) 1-44, ISSN 0079-6565
Publisher: Elsevier BV
DOI: 10.1016/j.pnmrs.2022.01.002

Autonomous reaction self-optimization using in-line high-field NMR spectroscopy

Author(s): Nour El Sabbagh, Margherita Bazzoni, Yuliia Horbenko, Aurélie Bernard, Daniel Cortés-Borda, Patrick Giraudeau, François-Xavier Felpin, Jean-Nicolas Dumez
Published in: Reaction Chemistry & Engineering, Issue 9, 2024, Page(s) 2599-2609, ISSN 2058-9883
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4re00270a

Scaling-up metabolomics: Current state and perspectives

Author(s): Ghina Hajjar; Millena C. Barros Santos; Justine Bertrand-Michel; Cécile Canlet; Florence Castelli; Nicolas Creusot; Sylvain Dechaumet; Binta Diémé; Franck Giacomoni; Patrick Giraudeau; Yann Guitton; Etienne Thévenot; Marie Tremblay-Franco; Christophe Junot; Fabien Jourdan; François Fenaille; Blandine Comte; Pierre Pétriacq; Estelle Pujos-Guillot
Published in: EISSN: 0165-9936, Issue 7, 2023, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2023.117225

In-line Multidimensional NMR Monitoring of Photochemical Flow Reactions

Author(s): Margherita Bazzoni, Célia Lhoste, Justine Bonnet, Kouakou Eric Konan, Aurélie Bernard, Patrick Giraudeau, François-Xavier Felpin, Jean-Nicolas Dumez
Published in: Chemistry: a European Journal, 2023, Page(s) e202203240, ISSN 1521-3765
Publisher: John Wiley and Sons
DOI: 10.1002/chem.202203240

NMR metabolite quantification of a synthetic urine sample: an inter-laboratory comparison of processing workflows

Author(s): Cécile Canlet; Catherine Deborde; Edern Cahoreau; Grégory Da Costa; Roselyne Gautier; Daniel Jacob; Cyril Jousse; Mélia Lacaze; Inès Le Mao; Estelle Martineau; Lindsay Peyriga; Tristan Richard; Virginie Silvestre; Mounir Traïkia; Annick Moing; Patrick Giraudeau
Published in: ISSN: 1573-3882, Issue 2, 2023, ISSN 1573-3890
Publisher: Springer
DOI: 10.1007/s11306-023-02028-4

Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization

Author(s): Joris Mandral, Johnnie Phuong, Jonathan Farjon, Patrick Giraudeau, Kerstin Münnemann, Jean-Nicolas Dumez
Published in: Journal of Magnetic Resonance Open, Issue 23, 2025, Page(s) 100195, ISSN 2666-4410
Publisher: Elsevier BV
DOI: 10.1016/j.jmro.2025.100195

Hyperpolarized ¹H and ¹³C NMR Spectroscopy in a Single Experiment for Metabolomics

Author(s): Arnab Dey; Benoît Charrier; Victor Ribay; Jean-Nicolas Dumez; Patrick Giraudeau
Published in: Crossref, Issue 4, 2023, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.3c02614

Hyperpolarized NMR metabolomics

Author(s): Victor Ribay, Clément Praud, Marine P. M. Letertre, Jean-Nicolas Dumez, Patrick Giraudeau
Published in: Current opinion in chemical biology, 2023, Page(s) 102307, ISSN 1879-0402
Publisher: Elsevier
DOI: 10.1016/j.cbpa.2023.102307

Ultrafast 2D 1H–1H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Author(s): Kawarpal Singh; Corentin Jacquemmoz; Patrick Giraudeau; Lucio Frydman; Jean-Nicolas Dumez
Published in: Chemical Communications, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc03079e

Evaluation of pure shift NMR methods for the analysis of complex metabolite mixtures with a benchtop NMR spectrometer

Author(s): Joris Mandral, Simon Roques, Jean-Nicolas Dumez, Patrick Giraudeau, Jonathan Farjon
Published in: Analytical Methods, Issue 17, 2025, Page(s) 3171-3182, ISSN 1759-9660
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5ay00006h

Broadband ultrafast 2D NMR spectroscopy for online monitoring in continuous flow

Author(s): Célia Lhoste; Margherita Bazzoni; Justine Bonnet; Aurélie Bernard; François-Xavier Felpin; Patrick Giraudeau; Jean-Nicolas Dumez
Published in: Analyst, Issue 9, 2023, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3an01165h

Optimization of heteronuclear ultrafast 2D NMR for the study of complex mixtures hyperpolarized by dynamic nuclear polarization

Author(s): Clément Praud; Victor Ribay; Arnab Dey; Benoît Charrier; Joris Mandral; Jonathan Farjon; Jean-Nicolas Dumez; Patrick Giraudeau
Published in: Crossref, Issue 6, 2023, ISSN 1759-9679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3ay01681a

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial

Author(s): Bertrand Cariou, An Thys, Arsênio Rodrigues Oliveira, Marine P. M. Letertre, Béatrice Guyomarch, Maxime Carpentier, Claire Cannet, Pierre Morcel, Audrey Ernould, Laurent Flet, Patrick Giraudeau, Samy Hadjadj, Cédric Le May, Mikaël Croyal
Published in: Diabetes, Obesity and Metabolism, Issue 27, 2025, Page(s) 3006-3016, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.16305

Quantitative NMR spectroscopy of complex mixtures

Author(s): Patrick Giraudeau
Published in: Chemical Communications, 2023, Page(s) 6627-6642, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc01455j

Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives

Author(s): Marine Letertre, Patrick Giraudeau, Pascal de Tullio
Published in: Frontiers in Molecular Biosciences - Metabolomics, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.698337

Fine optimization of a dissolution dynamic nuclear polarization experimental setting for 13C NMR of metabolic samples

Author(s): Arnab Dey, Benoît Charrier, Karine Lemaitre, Victor Ribay, Dmitry Eshchenko, Marc Schnell, Roberto Melzi, Quentin Stern, Samuel F. Cousin, James G. Kempf, Sami Jannin, Jean-Nicolas Dumez, and Patrick Giraudeau
Published in: Magnetic Resonance, Issue 26990016, 2022, ISSN 2699-0016
Publisher: Copernicus
DOI: 10.5194/mr-3-183-2022

Pure Shift NMR in Continuous Flow

Author(s): Margherita Bazzoni, Armand Régheasse, Elsa Caytan, François‐Xavier Felpin, Patrick Giraudeau, Aurélie Bernard, Ralph W. Adams, Gareth A. Morris, Mathias Nilsson, Jean‐Nicolas Dumez
Published in: Chemistry – A European Journal, Issue 31, 2025, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202403385

Combined Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry Approaches for Metabolomics

Author(s): Marine P. M. Letertre, Gaud Dervilly, Patrick Giraudeau
Published in: Analytical Chemistry, Issue 93/1, 2021, Page(s) 500-518, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c04371

Analytical Comparison of Two Quantitative HSQC Methods for the Absolute Quantitation of Metabolites

Author(s): Jérémy Marchand, Estelle Martineau, Jonathan Farjon, Patrick Giraudeau
Published in: Magnetic Resonance in Chemistry, Issue 63, 2025, Page(s) 434-444, ISSN 0749-1581
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrc.5525

Fast Multidimensional Flow Nuclear Magnetic Resonance at High Field for Real‐Time Reaction Monitoring and Flow Synthesis

Author(s): Margherita Bazzoni, Yuliia Horbenko, Nour El Sabbagh, Achille Marchand, Magdalena Grochowska‐Tatarczak, Aurélie Bernard, Patrick Giraudeau, François‐Xavier Felpin, Jean‐Nicolas Dumez
Published in: Chemistry–Methods, Issue 5, 2025, ISSN 2628-9725
Publisher: Wiley
DOI: 10.1002/cmtd.202400061

NMR-based metabolomics and fluxomics: developments and future prospects

Author(s): Patrick Giraudeau
Published in: The Analyst, Issue 145/7, 2020, Page(s) 2457-2472, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0an00142b

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

Author(s): Arnab Dey, Benoît Charrier, Estelle Martineau, Catherine Deborde, Elodie Gandriau, Annick Moing, Daniel Jacob, Dmitry Eshchenko, Marc Schnell, Roberto Melzi, Dennis Kurzbach, Morgan Ceillier, Quentin Chappuis, Samuel F. Cousin, James G. Kempf, Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau
Published in: Analytical Chemistry, Issue 92/22, 2020, Page(s) 14867-14871, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c03510

Book chapters (2)

Fast 2D NMR for metabolomics

Author(s): Clément Praud, Marine P.M. Letertre, Arnab Dey, Jean-Nicolas Dumez, Patrick Giraudeau
Published in: Fast 2D solution-state NMR, 2023, ISBN 978-1-83916-400-2
Publisher: Royal Society of Chemistry
DOI: 10.1039/bk9781839168062-00377

Fast 2D NMR for Reaction and Process Monitoring

Author(s): Margherita Bazzoni, Benjamin Lorandel, Célia Lhoste, Patrick Giraudeau, Jean-Nicolas Dumez
Published in: Fast 2D solution state NMR, 2023, ISBN 978-1-83916-400-2
Publisher: Royal Society of Chemistry
DOI: 10.1039/bk9781839168062-00251