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Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking

Project description

A unique approach to improving biomarker fingerprinting

Tracking biomarker origin is increasingly important in many different fields, such as life, environmental, food and forensic sciences. Combining metabolomics and fluxomics with isotopic fingerprinting shows great potential towards achieving this aim. Isotopic analysis by nuclear magnetic resonance (NMR) allows scientists to quantify with great precision the differences of isotopic contents on each site of a molecule. The EU-funded SUMMIT project has been established to address the current limitations of 13C isotopic NMR analysis. By using two powerful NMR methods – dissolution dynamic nuclear polarisation and ultrafast 2D NMR – the project will allow scientists to simultaneously measure 13C fingerprints from multiple low-concentration biomarkers in complex biological mixtures, a difficult feat to accomplish with existing methods.

Host institution

NANTES UNIVERSITE
Net EU contribution
€ 1 999 768,00
Address
1 Quai De Tourville
44000 Nantes
France
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Pays de la Loire Pays de la Loire Loire-Atlantique
 

Beneficiaries (1)

NANTES UNIVERSITE
France
Net EU contribution
€ 1 999 768,00
Address
1 Quai De Tourville
44000 Nantes
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Pays de la Loire Pays de la Loire Loire-Atlantique