Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking

Informazioni relative al progetto

SUMMIT

ID dell’accordo di sovvenzione: 814747

DOI

10.3030/814747

Progetto chiuso

Data della firma CE 6 Febbraio 2019

Data di avvio 1 Ottobre 2019

Data di completamento 30 Settembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 768,00

Contributo UE

€ 1 999 768,00

Coordinato da

NANTES UNIVERSITE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (29)

Hyperpolarized ¹³C NMR Spectroscopy of Urine Samples at Natural Abundance by Quantitative Dissolution Dynamic Nuclear Polarization

Autori: Victor Ribay; Arnab Dey; Benoît Charrier; Clément Praud; Joris Mandral; Jean‐Nicolas Dumez; Marine P. M. Letertre; Patrick Giraudeau
Pubblicato in: Crossref, Numero 6, 2023, Pagina/e e202302110, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202302110

Non‐uniform sampling to enhance the performance of compact NMR for characterizing new psychoactive substances

Autori: Thomas Castaing‐Cordier; Sélina Crasnier; Damien Dubois; Virginie Ladroue; Audrey Buleté; Cédric Prudhomme; Céline Charvoz; Fabrice Besacier; Denis Jacquemin; Patrick Giraudeau; Jonathan Farjon
Pubblicato in: Magnetic Resonance in Chemistry, 2024, ISSN 0749-1581
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrc.5416

Clean ¹H NMR Spectra of Products Directly from Batch and Flow Reaction Mixtures

Autori: Yuliia Horbenko, Martin Jaudronnet, Nour El Sabbagh, Margherita Bazzoni, Aurélie Bernard, Mathias Nilsson, Patrick Giraudeau, François‐Xavier Felpin, Jean‐Nicolas Dumez
Pubblicato in: ChemistryEurope, Numero 3, 2025, ISSN 2751-4765
Editore: Wiley
DOI: 10.1002/ceur.202500038

Hyperpolarized ¹³C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease

Autori: Victor Ribay, Benoît Charrier, Mikaël Croyal, Bertrand Cariou, Samy Hadjadj, Julien Boccard, Claire Cannet, Jean-Nicolas Dumez, Marine P. M. Letertre, Patrick Giraudeau
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, Pagina/e 644-650, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c12607

Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals

Autori: Anna J. Parker; Arnab Dey; Mohammad Usman Qureshi; Jakob M. Steiner; John W. Blanchard; Jochen Scheuer; Nikolas Tomek; Stephan Knecht; Felix Josten; Christoph Müller; Patrick Hautle; Ilai Schwartz; Patrick Giraudeau; Tim R. Eichhorn; Jean‐Nicolas Dumez
Pubblicato in: Crossref, Numero 7, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202312302

Exploring the complementarity of fast multipulse and multidimensional NMR methods for metabolomics: a chemical ecology case study

Autori: Aurore Michaud, Samuel Bertrand, Serge Akoka, Jonathan Farjon, Estelle Martineau, Nicolas Ruiz, Thibaut Robiou du Pont, Olivier Grovel, Patrick Giraudeau
Pubblicato in: Analytical Methods, Numero 16, 2024, Pagina/e 5166-5177, ISSN 1759-9660
Editore: Royal Society of Chemistry
DOI: 10.1039/d4ay01225a

Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation

Autori: Lucy Botros, Yang Liu, Charlotte Corbett, Dan Sørensen, Christina Szabo, Anton Bzhelyansky, Matthias Niemitz, Petrus Korhonen, Guido F. Pauli, Patrick Giraudeau, G. Joseph Ray
Pubblicato in: Journal of Natural Products, Numero 88, 2025, Pagina/e 877-888, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01013

Ultrafast 2D NMR for the analysis of complex mixtures

Autori: Célia Lhoste, Benjamin Lorandel, Clément Praud, Achille Marchand, Rituraj Mishra, Arnab Dey, Aurélie Bernard, Jean-Nicolas Dumez, Patrick Giraudeau
Pubblicato in: Progress in Nuclear Magnetic Resonance Spectroscopy, Numero 130-131, 2022, Pagina/e 1-44, ISSN 0079-6565
Editore: Elsevier BV
DOI: 10.1016/j.pnmrs.2022.01.002

Autonomous reaction self-optimization using in-line high-field NMR spectroscopy

Autori: Nour El Sabbagh, Margherita Bazzoni, Yuliia Horbenko, Aurélie Bernard, Daniel Cortés-Borda, Patrick Giraudeau, François-Xavier Felpin, Jean-Nicolas Dumez
Pubblicato in: Reaction Chemistry & Engineering, Numero 9, 2024, Pagina/e 2599-2609, ISSN 2058-9883
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4re00270a

Scaling-up metabolomics: Current state and perspectives

Autori: Ghina Hajjar; Millena C. Barros Santos; Justine Bertrand-Michel; Cécile Canlet; Florence Castelli; Nicolas Creusot; Sylvain Dechaumet; Binta Diémé; Franck Giacomoni; Patrick Giraudeau; Yann Guitton; Etienne Thévenot; Marie Tremblay-Franco; Christophe Junot; Fabien Jourdan; François Fenaille; Blandine Comte; Pierre Pétriacq; Estelle Pujos-Guillot
Pubblicato in: EISSN: 0165-9936, Numero 7, 2023, ISSN 0165-9936
Editore: Elsevier BV
DOI: 10.1016/j.trac.2023.117225

In-line Multidimensional NMR Monitoring of Photochemical Flow Reactions

Autori: Margherita Bazzoni, Célia Lhoste, Justine Bonnet, Kouakou Eric Konan, Aurélie Bernard, Patrick Giraudeau, François-Xavier Felpin, Jean-Nicolas Dumez
Pubblicato in: Chemistry: a European Journal, 2023, Pagina/e e202203240, ISSN 1521-3765
Editore: John Wiley and Sons
DOI: 10.1002/chem.202203240

NMR metabolite quantification of a synthetic urine sample: an inter-laboratory comparison of processing workflows

Autori: Cécile Canlet; Catherine Deborde; Edern Cahoreau; Grégory Da Costa; Roselyne Gautier; Daniel Jacob; Cyril Jousse; Mélia Lacaze; Inès Le Mao; Estelle Martineau; Lindsay Peyriga; Tristan Richard; Virginie Silvestre; Mounir Traïkia; Annick Moing; Patrick Giraudeau
Pubblicato in: ISSN: 1573-3882, Numero 2, 2023, ISSN 1573-3890
Editore: Springer
DOI: 10.1007/s11306-023-02028-4

Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization

Autori: Joris Mandral, Johnnie Phuong, Jonathan Farjon, Patrick Giraudeau, Kerstin Münnemann, Jean-Nicolas Dumez
Pubblicato in: Journal of Magnetic Resonance Open, Numero 23, 2025, Pagina/e 100195, ISSN 2666-4410
Editore: Elsevier BV
DOI: 10.1016/j.jmro.2025.100195

Hyperpolarized ¹H and ¹³C NMR Spectroscopy in a Single Experiment for Metabolomics

Autori: Arnab Dey; Benoît Charrier; Victor Ribay; Jean-Nicolas Dumez; Patrick Giraudeau
Pubblicato in: Crossref, Numero 4, 2023, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.3c02614

Hyperpolarized NMR metabolomics

Autori: Victor Ribay, Clément Praud, Marine P. M. Letertre, Jean-Nicolas Dumez, Patrick Giraudeau
Pubblicato in: Current opinion in chemical biology, 2023, Pagina/e 102307, ISSN 1879-0402
Editore: Elsevier
DOI: 10.1016/j.cbpa.2023.102307

Ultrafast 2D 1H–1H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Autori: Kawarpal Singh; Corentin Jacquemmoz; Patrick Giraudeau; Lucio Frydman; Jean-Nicolas Dumez
Pubblicato in: Chemical Communications, 2021, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc03079e

Evaluation of pure shift NMR methods for the analysis of complex metabolite mixtures with a benchtop NMR spectrometer

Autori: Joris Mandral, Simon Roques, Jean-Nicolas Dumez, Patrick Giraudeau, Jonathan Farjon
Pubblicato in: Analytical Methods, Numero 17, 2025, Pagina/e 3171-3182, ISSN 1759-9660
Editore: Royal Society of Chemistry
DOI: 10.1039/d5ay00006h

Broadband ultrafast 2D NMR spectroscopy for online monitoring in continuous flow

Autori: Célia Lhoste; Margherita Bazzoni; Justine Bonnet; Aurélie Bernard; François-Xavier Felpin; Patrick Giraudeau; Jean-Nicolas Dumez
Pubblicato in: Analyst, Numero 9, 2023, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/d3an01165h

Optimization of heteronuclear ultrafast 2D NMR for the study of complex mixtures hyperpolarized by dynamic nuclear polarization

Autori: Clément Praud; Victor Ribay; Arnab Dey; Benoît Charrier; Joris Mandral; Jonathan Farjon; Jean-Nicolas Dumez; Patrick Giraudeau
Pubblicato in: Crossref, Numero 6, 2023, ISSN 1759-9679
Editore: Royal Society of Chemistry
DOI: 10.1039/d3ay01681a

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial

Autori: Bertrand Cariou, An Thys, Arsênio Rodrigues Oliveira, Marine P. M. Letertre, Béatrice Guyomarch, Maxime Carpentier, Claire Cannet, Pierre Morcel, Audrey Ernould, Laurent Flet, Patrick Giraudeau, Samy Hadjadj, Cédric Le May, Mikaël Croyal
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 27, 2025, Pagina/e 3006-3016, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.16305

Quantitative NMR spectroscopy of complex mixtures

Autori: Patrick Giraudeau
Pubblicato in: Chemical Communications, 2023, Pagina/e 6627-6642, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cc01455j

Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives

Autori: Marine Letertre, Patrick Giraudeau, Pascal de Tullio
Pubblicato in: Frontiers in Molecular Biosciences - Metabolomics, 2021, ISSN 2296-889X
Editore: Frontiers
DOI: 10.3389/fmolb.2021.698337

Fine optimization of a dissolution dynamic nuclear polarization experimental setting for 13C NMR of metabolic samples

Autori: Arnab Dey, Benoît Charrier, Karine Lemaitre, Victor Ribay, Dmitry Eshchenko, Marc Schnell, Roberto Melzi, Quentin Stern, Samuel F. Cousin, James G. Kempf, Sami Jannin, Jean-Nicolas Dumez, and Patrick Giraudeau
Pubblicato in: Magnetic Resonance, Numero 26990016, 2022, ISSN 2699-0016
Editore: Copernicus
DOI: 10.5194/mr-3-183-2022

Pure Shift NMR in Continuous Flow

Autori: Margherita Bazzoni, Armand Régheasse, Elsa Caytan, François‐Xavier Felpin, Patrick Giraudeau, Aurélie Bernard, Ralph W. Adams, Gareth A. Morris, Mathias Nilsson, Jean‐Nicolas Dumez
Pubblicato in: Chemistry – A European Journal, Numero 31, 2025, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202403385

Combined Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry Approaches for Metabolomics

Autori: Marine P. M. Letertre, Gaud Dervilly, Patrick Giraudeau
Pubblicato in: Analytical Chemistry, Numero 93/1, 2021, Pagina/e 500-518, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c04371

Analytical Comparison of Two Quantitative HSQC Methods for the Absolute Quantitation of Metabolites

Autori: Jérémy Marchand, Estelle Martineau, Jonathan Farjon, Patrick Giraudeau
Pubblicato in: Magnetic Resonance in Chemistry, Numero 63, 2025, Pagina/e 434-444, ISSN 0749-1581
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrc.5525

Fast Multidimensional Flow Nuclear Magnetic Resonance at High Field for Real‐Time Reaction Monitoring and Flow Synthesis

Autori: Margherita Bazzoni, Yuliia Horbenko, Nour El Sabbagh, Achille Marchand, Magdalena Grochowska‐Tatarczak, Aurélie Bernard, Patrick Giraudeau, François‐Xavier Felpin, Jean‐Nicolas Dumez
Pubblicato in: Chemistry–Methods, Numero 5, 2025, ISSN 2628-9725
Editore: Wiley
DOI: 10.1002/cmtd.202400061

NMR-based metabolomics and fluxomics: developments and future prospects

Autori: Patrick Giraudeau
Pubblicato in: The Analyst, Numero 145/7, 2020, Pagina/e 2457-2472, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/d0an00142b

Hyperpolarized NMR Metabolomics at Natural 13 C Abundance

Autori: Arnab Dey, Benoît Charrier, Estelle Martineau, Catherine Deborde, Elodie Gandriau, Annick Moing, Daniel Jacob, Dmitry Eshchenko, Marc Schnell, Roberto Melzi, Dennis Kurzbach, Morgan Ceillier, Quentin Chappuis, Samuel F. Cousin, James G. Kempf, Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau
Pubblicato in: Analytical Chemistry, Numero 92/22, 2020, Pagina/e 14867-14871, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c03510

Book chapters (2)

Fast 2D NMR for metabolomics

Autori: Clément Praud, Marine P.M. Letertre, Arnab Dey, Jean-Nicolas Dumez, Patrick Giraudeau
Pubblicato in: Fast 2D solution-state NMR, 2023, ISBN 978-1-83916-400-2
Editore: Royal Society of Chemistry
DOI: 10.1039/bk9781839168062-00377

Fast 2D NMR for Reaction and Process Monitoring

Autori: Margherita Bazzoni, Benjamin Lorandel, Célia Lhoste, Patrick Giraudeau, Jean-Nicolas Dumez
Pubblicato in: Fast 2D solution state NMR, 2023, ISBN 978-1-83916-400-2
Editore: Royal Society of Chemistry
DOI: 10.1039/bk9781839168062-00251