Descripción del proyecto
Un cambio de tornas en la resistencia a los antimicrobianos
La resistencia a los antimicrobianos supone la mayor amenaza para la salud global; numerosas infecciones se están volviendo más difíciles de tratar porque los antibióticos están perdiendo efectividad. La sepsis afecta a más personas que el cáncer de pulmón, mama y próstata juntos, se desarrolla rápidamente y ataca a múltiples órganos, lo que, a menudo, provoca un choque séptico y la muerte. La empresa sueca Gradientech se propone desarrollar e introducir en la práctica clínica una herramienta de diagnóstico ultrarrápido para los antibiogramas basada en una plataforma tecnológica patentada. La nueva herramienta combina la microfluídica avanzada con un análisis y detección de imágenes continuos, y reducirá el plazo de conclusión del antibiograma a dos horas. El equipo del proyecto QuickMIC, financiado con fondos europeos, desarrollará un plan de negocios para futuros estudios clínicos y actividades de comercialización.
Objetivo
The aim of the project is to bring QuickMIC™, an ultra-rapid diagnostic tool for Antibiotic Susceptibility Testing (AST) to the market and clinical practice. AST is usually carried out to determine which antibiotic will be the most appropriate in treating a bacterial infection in a particular patient. Sepsis is the major cause of death as a result of an infection today. It affects approx. 30 million of people every year worldwide. About 20 % of the patients do not survive the disease. Currently, it can take up to 48 hours for the current golden standard AST method to produce reliable diagnostic results. Therefore, doctors empirically treat sepsis patients with wide-spectrum antibiotics while the blood samples are being tested. The globally escalating antimicrobial resistance (AMR) has resulted in empirical treatment being unsuccessful more and more often. Misuse of antibiotics additionally contributes to increasing resistance. The improvement of survival rates in sepsis and the decrease in AMR will only be possible with access to a quicker AST tool. To address this unmet clinical need, Gradientech is developing an ultra-rapid AST system, QuickMIC™, based on a patented technology platform. By combining i) advanced microfluidics and ii) continuous image detection and analysis, QuickMIC™ can reduce the time of an AST to two hours. Besides being the fastest AST under development, QuickMIC™ is also a low-price alternative compared to its direct competitors. By commercializing QuickMIC™, Gradientech will make an important contribution to fighting AMR in Europe. Moreover, we will significantly improve the diagnosis and treatment of sepsis. A continued development of QuickMIC™ will result in a CE-IVD marking by early 2019. In the Phase 1 project, we will develop a business plan that will guide the future clinical studies and commercialisation activities. If successful, the overall innovation effort will take Gradientech to a new level of competitiveness and growth.
Ámbito científico
- medical and health sciencesclinical medicinesurgery
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SMEInst-2018-2020-1
Régimen de financiación
SME-1 - SME instrument phase 1Coordinador
75183 UPPSALA
Suecia
Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención.