Spatial fractionation of the dose in proton therapy: a novel therapeutic approach

Project description

Improving the outcome of radiotherapy

Radiotherapy (RT) for cancer is limited by the dose tolerance of normal tissues. Therefore, there is a need to develop approaches for increasing normal tissue resistance. The EU-funded PROTONMBRT project has developed a proton minibeam radiation therapy which combines protons for RT, sub-millimetric field sizes and a spatial fractionation of the dose. Researchers will test the therapeutic index of this therapy in radioresistant tumours and develop a complete set of dosimetry tools for clinical implementation. Particular emphasis will be given to unravelling the biological mechanisms involved and to find the physical parameters that maximise the therapeutic index for radioresistant tumours, such as high-grade gliomas.

Fields of science

• medical and health sciences › clinical medicine › oncology

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2018-COG - ERC Consolidator Grant

Call for proposal

ERC-2018-COG

See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Net EU contribution

€ 1 997 870,00

Address

Rue Michel Ange 3
75794 Paris
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00

Beneficiaries (1)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

Net EU contribution

€ 1 997 870,00

Address

Rue Michel Ange 3
75794 Paris

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00