Spatial fractionation of the dose in proton therapy: a novel therapeutic approach

Project Information

PROTONMBRT

Grant agreement ID: 817908

DOI 10.3030/817908

EC signature date 25 February 2019

Start date 1 October 2019

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 997 870,00

EU contribution € 1 997 870,00

Coordinated by

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Combining FLASH and spatially fractionated radiation therapy: The best of both worlds

Author(s): Tim Schneider, Cristian Fernandez Palomo, Annaig Bertho, Jennifer Fazzari, Lorea Iturri, Olga A. Martin, Verdiana Trappeti, Valentin Djonov, Yolanda Prezado
Published in: Radiotherapy and Oncology, Issue 01678140, 2022, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2022.08.004

Monte Carlo Comparison of Proton and Helium-ion Minibeam Generation Techniques

Author(s): Tim Schneider, Ludovic De Marzi, Annalisa Patriarca, Yolanda Prezado
Published in: Frontiers in Physics, Issue 9, 2021, ISSN 2296-424X
Publisher: Frontiers
DOI: 10.3389/fphy.2021.595721

Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy

Author(s): Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Elise Brisebard, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Catherine Sébrié, Laurène Jourdain, Ludovic de Marzi, Frédéric Pouzoulet, Jane Muret, Pierre Verrelle, Yolanda Prezado
Published in: Communications Medicine, Issue 12, 2023, ISSN 2730-664X
Publisher: Nature
DOI: 10.1038/s43856-023-00411-9

Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy

Author(s): AM Leite, M G Ronga, M Giorgi, Y Ristic, Y Perrot, F Trompier, Y Prezado, G Créhange, L De Marzi
Published in: Physics in Medicine and Biology, Issue 12, 2021, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac3209

Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors

Author(s): Yolanda Prezado
Published in: Comptes Rendus Biologies, Issue 4, 2021, Page(s) 409-420, ISSN 1631-0691
Publisher: Elsevier Masson
DOI: 10.5802/crbiol.71

Divide and conquer: spatially fractionated radiation therapy

Author(s): Yolanda Prezado
Published in: Expert Reviews in Molecular Medicine, 2022, ISSN 1462-3994
Publisher: Cambridge University Press
DOI: 10.1017/erm.2021.34

Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions

Author(s): Charlotte Lamirault, Valérie Doyère, Marjorie Juchaux, Frederic Pouzoulet, Dalila Labiod, Remi Dendale, Annalisa Patriarca, Catherine Nauraye, Marine Le Dudal, Grégory Jouvion, David Hardy, Nicole El Massioui, Yolanda Prezado
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-70371-w

First Evaluation of Temporal and Spatial Fractionation in Proton Minibeam Radiation Therapy of Glioma-Bearing Rats

Author(s): Annaïg Bertho,Ramon Ortiz,Marjorie Juchaux,Cristèle Gilbert,Charlotte Lamirault,Frederic Pouzoulet,Laura Polledo,Alethea Liens,Nils Warfving,Catherine Sebrie ,Laurène Jourdain,Annalisa Patriarca,Ludovic de Marzi, Yolanda Prezado
Published in: Cancers, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194865

Proton Minibeam Radiation Therapy and Arc Therapy: Proof ofConcept of a Winning Alliance

Author(s): Ramon Ortiz, Ludovic De Marzi, and Yolanda Prezado
Published in: Cancers, Issue 12, 2022, Page(s) 13, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010116

Monte Carlo study of the free radical yields in minibeam radiation therapy

Author(s): Thongchai Masilela, Yolanda Prezado
Published in: Medical Physics, Issue 12, 2023, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.16475

Preclinical dosimetry in proton minibeam radiation therapy: Robustness analysis and guidelines

Author(s): Ramon Ortiz, Ludovic de Marzi, Yolanda Prezado
Published in: Medical Physics, Issue 24734209, 2022, ISSN 2473-4209
Publisher: Wiley
DOI: 10.1002/mp.15780

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

Author(s): Tim Schneider, Ludovic De Marzi, Annalisa Patriarca, Yolanda Prezado
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-58052-0

First proton minibeam radiation therapy treatment plan evaluation

Author(s): P. Lansonneur, H. Mammar, C. Nauraye, A. Patriarca, E. Hierso, R. Dendale, Y. Prezado, L. De Marzi
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-63975-9

Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies

Author(s): Cristian Fernandez-Palomo, Sha Chang, Yolanda Prezado
Published in: Cancers, Issue 20726694, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153625

A scanning dynamic collimator for spot-scanning proton minibeam production

Author(s): Marios Sotiropoulos, Yolanda Prezado
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-97941-w

Evaluation of the role of the immune system response following minibeam radiation therapy

Author(s): Annaig Bertho, Lorea Iturri, Elise Brisebard, Marjorie Juchaux, Cristele Gilbert, Ramon Ortiz, Catherine Sebrie, Laurene Jourdain, Gabriel Ramsay, Charlotte Lamirault, Frederic Pouzoulet, Yolanda Prezado
Published in: International Journal Radiation Oncology Biology Physics, Issue 03603016, 2022, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.08.011

Converging Proton Minibeams with Magnetic Fields forOptimized Radiation Therapy: A Proof of Concept

Author(s): Marco Cavallone, Ludovic de Marzi, Yolanda Prezado
Published in: Cancers, Issue 13, 2022, Page(s) 26-40, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010026

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Author(s): Lennart Volz; Claire-Anne Reidel; Marco Durante; Yolanda Prezado; Christoph Schuy; Uli Weber; Christian Graeff
Published in: Instruments; Volume 7; Issue 2; Pages: 18, Issue 5, 2023, ISSN 2410-390X
Publisher: MDPI
DOI: 10.3390/instruments7020018

Radiation quality correction factors for improved dosimetry in preclinical minibeam radiotherapy

Author(s): Marios Sotiropoulos, Yolanda Prezado
Published in: Medical Physics, Issue 24734209, 2022, ISSN 2473-4209
Publisher: Wiley
DOI: 10.1002/mp.15838

A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy

Author(s): Yolanda Prezado, Ryochi Hirayama ,Naruhiro Matsufuji ,Taku Inaniwa,Immaculada Martínez-Rovira ,Olivier Seksek, Annaïg Bertho,Sachiko Koike,Dalila Labiod ,Frederic Pouzoulet ,Laura Polledo ,Nils Warfving ,Aléthéa Liens,Judith Bergs andTakashi Shimokawa
Published in: Cancers, Issue 13, 2021, Page(s) 20726694, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061356

Spatially Modulated Proton Minibeams Results in the Same Increase of Lifespan as a Uniform Target Dose Coverage in F98-Glioma-Bearing Rats

Author(s): Charlotte Lamirault, Elise Brisebard, Annalisa Patriarca, Marjorie Juchaux, Delphine Crepin, Dalila Labiod, Frederic Pouzoulet, Catherine Sebrie, Laurene Jourdain, Marine Le Dudal, David Hardy, Ludovic De Marzi, Remi Dendale, Gregory Jouvion, Yolanda Prezado
Published in: Radiation Research, Issue 12, 2020, ISSN 1938-5404
Publisher: AllenPress
DOI: 10.1667/rade-19-00013.1

Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model

Author(s): Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Catherine Sebrie, Laurène Jourdain, Frédéric Pouzoulet, Pierre Verrelle, Ludovic De Marzi, Yolanda Prezado
Published in: International Journal Radiation Oncology, Biology, Physics, Issue 12, 2023, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.12.018

Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams

Author(s): Tim Schneider, Annalisa Patriarca, Alberto Degiovanni, Manuel Gallas, Yolanda Prezado
Published in: Cancers, Issue 13/18, 2021, Page(s) 4657, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13184657

Proton minibeam radiation therapy for treating metastases: A treatment plan study

Author(s): Ramon Ortiz, Rezart Belshi, Ludovic De Marzi, Yolanda Prezado
Published in: Medical Physics, Issue 12, 2023, ISSN 2473-4209
Publisher: Wiley
DOI: 10.1002/mp.16203

Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation

Author(s): Tim Schneider; Denis Malaise; Frédéric Pouzoulet; Yolanda Prezado
Published in: Cancers, Issue 12, 2023, ISSN 2410-390X
Publisher: MDPI
DOI: 10.3390/cancers15030679

Intellectual Property Rights

Patent (1)

DEVICE, APPARATUS AND METHOD FOR MINIBEAM RADIATION THERAPY

Application/Publication number: 20 20082766
Date: 2020-11-19
Applicant(s): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS