PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL

Project Information

METAPTPs

Grant agreement ID: 817940

DOI

10.3030/817940

EC signature date 25 March 2019

Start date 1 April 2019

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 966 906,00

EU contribution

€ 1 966 906,00

Coordinated by

UNIVERSITE LIBRE DE BRUXELLES
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Author(s): Bernat Elvira; Valerie Vandenbempt; Julia Bauzá-Martinez; Raphaël Crutzen; Javier Negueruela; Hazem Ibrahim; Matthew L. Winder; Manoja K. Brahma; Beata Vekeriotaite; Pieter-Jan Martens; Sumeet Pal Singh; Fernando Rossello; Pascale Lybaert; Timo Otonkoski ; Conny Gysemans ; Wei Wu; Esteban N. Gurzov
Published in: Diabetes, Issue Volume 71, Issue 4, 2022, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0443

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

Author(s): Takiishi, Tatiana ;Xiao, Peng ;Franchimont, Marie;Gilglioni, Eduardo Hideo ;Arroba, Erick ;Gurzov, Esteban Nicolas ;Bertrand, Marc ;Cardozo, Alessandra K
Published in: Molecular metabolism, Issue 69, 2023, Page(s) 101681, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101681

Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor

Author(s): Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens
Published in: iScience, Issue 27, 2025, Page(s) 111336, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2024.111336

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity

Author(s): Anaïs Schaschkow, Lokman Pang, Valerie Vandenbempt, Bernat Elvira, Sara A. Litwak, Beata Vekeriotaite, Elisa Maillard, Marjorie Vermeersch, Flavia M.M. Paula, Michel Pinget, David Perez-Morga, Daniel J. Gough, Esteban N. Gurzov
Published in: Diabetes, Issue 70/9, 2021, Page(s) 2026-2041, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1222

Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma

Author(s): Talamantes, Stephanie; Lisjak, Michela; Gilglioni, Eduardo Hideo; Llamoza-Torres, Camilo; Ramos-Molina, Bruno; Gurzov, Esteban Nicolas
Published in: JHEP Reports, Issue Volume 5, Issue 9, 2023, Page(s) 100811, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2023.100811

Insulin-Binding Peptide Probes Provide a Novel Strategy for Pancreatic β-Cell Imaging

Author(s): Maria Eriksson, Sara A. Litwak, Yan Yun, William J. Stanley, Peter Thorn, Ulf Ahlgren, Esteban N. Gurzov
Published in: Molecular Pharmaceutics, 2021, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.1c00616

HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes

Author(s): Valerie Vandenbempt, Sema Elif Eski, Manoja K. Brahma, Ao Li, Javier Negueruela, Ylke Bruggeman, Stéphane Demine, Peng Xiao, Alessandra K. Cardozo, Nicolas Baeyens, Luciano G. Martelotto, Sumeet Pal Singh, Eliana Mariño, Conny Gysemans, Esteban N. Gurzov
Published in: iScience, Issue 27, 2025, Page(s) 108694, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2023.108694

Therapeutic potential of stem cell‐derived somatic cells to treat metabolic dysfunction‐associated steatotic liver disease and diabetes

Author(s): Eduardo H. Gilglioni, Mayank Bansal, Wadsen St‐Pierre‐Wijckmans, Stephanie Talamantes, Alvile Kasarinaite, David C. Hay, Esteban N. Gurzov
Published in: Obesity Reviews, 2025, ISSN 1467-7881
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/obr.13899

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

Author(s): Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53733-0

NF-kappaB-inducing kinase (NIK) is activated in pancreatic beta-cells but does not contribute to the development of diabete

Author(s): Xiao, Peng; Takiishi, Tatiana; Moretti Violato, Natalia; Licata, Giada; Dotta, Francesco; Sebastiani, Guido; MARSELLI, LORELLA; Singh, Sumeet Pal; Sze, Mozes; Van Loo, Geert; Dejardin, Emmanuel; Gurzov, Esteban Nicolas; Cardozo, Alessandra K
Published in: Cell death & disease,, Issue 13,5, 2022, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-04931-5

Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice

Author(s): Brahma, Manoja Kumar; Xiao, Peng; Popa, Madalina; Negueruela Escudero, Javier; Vandenbempt, Valerie; Demine, Stéphane; Cardozo, Alessandra K; Gurzov, Esteban Nicolas
Published in: Nutrients, Issue 14,18, 2022, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14183866

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Author(s): Esteban N. Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S. Garcia Ribeiro, Martin Gotthardt
Published in: Trends in Endocrinology & Metabolism, 2020, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2020.10.002

Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Author(s): Manoja K. Brahma, Eduardo H. Gilglioni, Lang Zhou, Eric Trépo, Pengyu Chen, Esteban N. Gurzov
Published in: Oncogene, Issue 40/33, 2021, Page(s) 5155-5167, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-021-01950-y

Protocol for real-time glycolytic monitoring in mammalian cells using confocal microscopy and HYlight, a biosensor for fructose 1,6-bisphosphate

Author(s): Israel Pérez-Chávez, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens
Published in: STAR Protocols, Issue 6, 2025, Page(s) 103792, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2025.103792

Protocol for CRISPR-Cas12a genome editing of protein tyrosine phosphatases in human pluripotent stem cells and functional β-like cell generation

Author(s): Javier Negueruela, Valerie Vandenbempt, Stephanie Talamantes, Francisco Ribeiro-Costa, Mariana Nunes, André Dias, Mayank Bansal, Esteban N. Gurzov
Published in: STAR Protocols, Issue 5, 2025, Page(s) 103297, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2024.103297

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

Author(s): Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal, Esteban N. Gurzov
Published in: Stem Cell Research & Therapy, Issue 16, 2025, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-025-04314-5