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PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL

Publications

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Author(s): Bernat Elvira; Valerie Vandenbempt; Julia Bauzá-Martinez; Raphaël Crutzen; Javier Negueruela; Hazem Ibrahim; Matthew L. Winder; Manoja K. Brahma; Beata Vekeriotaite; Pieter-Jan Martens; Sumeet Pal Singh; Fernando Rossello; Pascale Lybaert; Timo Otonkoski ; Conny Gysemans ; Wei Wu; Esteban N. Gurzov
Published in: Diabetes, Issue Volume 71, Issue 4, 2022, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0443

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

Author(s): Takiishi, Tatiana ;Xiao, Peng ;Franchimont, Marie;Gilglioni, Eduardo Hideo ;Arroba, Erick ;Gurzov, Esteban Nicolas ;Bertrand, Marc ;Cardozo, Alessandra K
Published in: Molecular metabolism, Issue 69, 2023, Page(s) 101681, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101681

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity

Author(s): Anaïs Schaschkow, Lokman Pang, Valerie Vandenbempt, Bernat Elvira, Sara A. Litwak, Beata Vekeriotaite, Elisa Maillard, Marjorie Vermeersch, Flavia M.M. Paula, Michel Pinget, David Perez-Morga, Daniel J. Gough, Esteban N. Gurzov
Published in: Diabetes, Issue 70/9, 2021, Page(s) 2026-2041, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1222

Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma

Author(s): Talamantes, Stephanie; Lisjak, Michela; Gilglioni, Eduardo Hideo; Llamoza-Torres, Camilo; Ramos-Molina, Bruno; Gurzov, Esteban Nicolas
Published in: JHEP Reports, Issue Volume 5, Issue 9, 2023, Page(s) 100811, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2023.100811

Insulin-Binding Peptide Probes Provide a Novel Strategy for Pancreatic β-Cell Imaging

Author(s): Maria Eriksson, Sara A. Litwak, Yan Yun, William J. Stanley, Peter Thorn, Ulf Ahlgren, Esteban N. Gurzov
Published in: Molecular Pharmaceutics, 2021, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.1c00616

NF-kappaB-inducing kinase (NIK) is activated in pancreatic beta-cells but does not contribute to the development of diabete

Author(s): Xiao, Peng; Takiishi, Tatiana; Moretti Violato, Natalia; Licata, Giada; Dotta, Francesco; Sebastiani, Guido; MARSELLI, LORELLA; Singh, Sumeet Pal; Sze, Mozes; Van Loo, Geert; Dejardin, Emmanuel; Gurzov, Esteban Nicolas; Cardozo, Alessandra K
Published in: Cell death & disease,, Issue 13,5, 2022, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-04931-5

Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice

Author(s): Brahma, Manoja Kumar; Xiao, Peng; Popa, Madalina; Negueruela Escudero, Javier; Vandenbempt, Valerie; Demine, Stéphane; Cardozo, Alessandra K; Gurzov, Esteban Nicolas
Published in: Nutrients, Issue 14,18, 2022, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14183866

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Author(s): Esteban N. Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S. Garcia Ribeiro, Martin Gotthardt
Published in: Trends in Endocrinology & Metabolism, 2020, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2020.10.002

Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Author(s): Manoja K. Brahma, Eduardo H. Gilglioni, Lang Zhou, Eric Trépo, Pengyu Chen, Esteban N. Gurzov
Published in: Oncogene, Issue 40/33, 2021, Page(s) 5155-5167, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-021-01950-y

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