PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL

Project description

The role of tyrosine phosphatases in metabolic disorders

Emerging evidence indicates that protein tyrosine phosphatases (PTPs) are implicated in insulin and glucose signalling, serving as molecular switches for key events in the development of diabetes. Oxidative stress inhibits PTP activity and is associated with obesity and inflammation. Scientists of the EU-funded METAPTPs project have developed an innovative proteomics approach for quantifying PTP oxidation in metabolic cells of patients with diabetes. Insight into PTP inactivation will help determine the impact of PTP deficiency on cellular responses and diabetes development. Moreover, the project will propose specific antioxidants or diets capable of restoring PTP function and reversing metabolic disorders.

Fields of science

Host institution

UNIVERSITE LIBRE DE BRUXELLES

Net EU contribution

€ 1 966 906,00

Address

Avenue Franklin Roosevelt 50
1050 Bruxelles
Belgium

Region

Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)