Project description
The role of tyrosine phosphatases in metabolic disorders
Emerging evidence indicates that protein tyrosine phosphatases (PTPs) are implicated in insulin and glucose signalling, serving as molecular switches for key events in the development of diabetes. Oxidative stress inhibits PTP activity and is associated with obesity and inflammation. Scientists of the EU-funded METAPTPs project have developed an innovative proteomics approach for quantifying PTP oxidation in metabolic cells of patients with diabetes. Insight into PTP inactivation will help determine the impact of PTP deficiency on cellular responses and diabetes development. Moreover, the project will propose specific antioxidants or diets capable of restoring PTP function and reversing metabolic disorders.
Fields of science
- natural scienceschemical scienceselectrochemistryelectrolysis
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesbasic medicinepathology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- medical and health scienceshealth sciencesnutritionobesity
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
1050 Bruxelles
Belgium
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Beneficiaries (1)
1050 Bruxelles
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