Descripción del proyecto
Prácticas de selección genómica para la industria agropecuaria
La anotación funcional del genoma indica qué genes son transcripcionalmente activos en términos espaciotemporales. La identificación de las regiones o elementos reguladores responsables de la activación de estos genes es importante no solo para el bienestar de los seres humanos, sino también para las industrias agropecuaria y biotecnológica. El proyecto GENE-SWitCH, financiado con fondos europeos, se centra en el genoma del ganado porcino y aviar y tiene como objetivo descubrir loci genéticos que pueden contribuir a la cría y producción animal sostenible. Conocer mejor la influencia epigenética de la dieta materna ayudará a optimizar las prácticas existentes y ofrecerá beneficios inmediatos para el sector agropecuario.
Objetivo
GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. The activation status of functional genome sequences varies across time and space, and in response to environmental perturbations. In full coordination and synergy with global effort and ongoing projects of the Functional Annotation of ANimal Genomes (FAANG) community, we will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG. A comprehensive plan of dissemination and outreach activities to a large audience of stakeholders will be implemented. The GENE-SWitCH consortium brings together partners representing pan-European excellence (including the academic institutions which pioneered FAANG) and world-leading animal breeding and biotech industry in a true co-creation effort. Overall, GENE-SWitCH will contribute to the global FAANG effort considerably, demonstrate how functional annotation of genomes can foster the advancement of genomic selection for immediate benefit to the breeding industry, and produce cutting-edge research paving the way to new studies and strategies for sustainable productions.
Ámbito científico
Programa(s)
- H2020-EU.3.2. - SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy Main Programme
- H2020-EU.3.2.1.1. - Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience
- H2020-EU.3.2.3.1. - Developing sustainable and environmentally-friendly fisheries
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SFS-2018-2
Régimen de financiación
RIA - Research and Innovation actionCoordinador
75007 Paris
Francia