Descrizione del progetto
Pratiche di selezione genomica nel settore agricolo
L’annotazione funzionale del genoma fornisce un’indicazione di quali geni sono trascrizionalmente attivi nello spazio e nel tempo. Individuare le regioni o gli elementi regolatori responsabili di questa attivazione genica è importante non solo per il benessere degli esseri umani, ma anche nei settori agricolo e delle biotecnologie. Il progetto GENE-SWitCH, finanziato dall’UE, si concentra sul genoma dei suini e del pollame e si propone di scoprire i loci genetici che possono contribuire all’allevamento e alla produzione sostenibili. La comprensione dell’influenza epigenetica della dieta materna contribuirà a ottimizzare le pratiche esistenti con un beneficio immediato per il settore agricolo.
Obiettivo
GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. The activation status of functional genome sequences varies across time and space, and in response to environmental perturbations. In full coordination and synergy with global effort and ongoing projects of the Functional Annotation of ANimal Genomes (FAANG) community, we will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG. A comprehensive plan of dissemination and outreach activities to a large audience of stakeholders will be implemented. The GENE-SWitCH consortium brings together partners representing pan-European excellence (including the academic institutions which pioneered FAANG) and world-leading animal breeding and biotech industry in a true co-creation effort. Overall, GENE-SWitCH will contribute to the global FAANG effort considerably, demonstrate how functional annotation of genomes can foster the advancement of genomic selection for immediate benefit to the breeding industry, and produce cutting-edge research paving the way to new studies and strategies for sustainable productions.
Campo scientifico
Programma(i)
- H2020-EU.3.2. - SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy Main Programme
- H2020-EU.3.2.1.1. - Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience
- H2020-EU.3.2.3.1. - Developing sustainable and environmentally-friendly fisheries
Argomento(i)
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
75007 Paris
Francia