Therapeutic Allele Engineering: A novel technology for cell therapy

Project Information

TALE

Grant agreement ID: 818806

DOI

10.3030/818806

Project closed

EC signature date 7 February 2019

Start date 1 June 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 397 082,00

EU contribution

€ 2 397 082,00

Coordinated by

UNIVERSITAT BASEL
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

Author(s): Romina Marone; Emmanuelle Landmann; Anna Devaux; Rosalba Lepore; Denis Seyres; Jessica Zuin; Thomas Burgold; Corinne Engdahl; Giuseppina Capoferri; Alessandro Dell’Aglio; Clément Larrue; Federico Simonetta; Julia Rositzka; Manuel Rhiel; Geoffroy Andrieux; Danielle N. Gallagher; Markus S. Schröder; Amélie Wiederkehr; Alessandro Sinopoli; Valentin Do Sacramento; Anna Haydn; Laura Garcia-Prat; C
Published in: Journal of Experimental Medicine, 220 (12), Issue 4, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20231235

Selective haematological cancer eradication with preserved haematopoiesis

Author(s): Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell’ Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C. Wellinger, Ian Kirby, Patrick H. Van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C. Widmer, Shengda
Published in: Nature, Issue 630, 2024, Page(s) 728-735, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07456-3

Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells

Author(s): Marianne Dölz; Marko Hasiuk; John D. Gagnon; Mara Kornete; Romina Marone; Glenn Bantug; Robin Kageyama; Christoph Hess; K. Mark Ansel; Denis Seyres; Julien Roux; Lukas T. Jeker
Published in: iScience, Issue 1, 2022, ISSN 2589-0042
Publisher: Cell Press, Elsevier Inc.
DOI: 10.1016/j.isci.2022.105372

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Author(s): Marcel P. Trefny; Nicole Kirchhammer; Priska Auf der Maur; Marina Natoli; Dominic Schmid; Markus Germann; Laura Fernandez Rodriguez; Petra Herzig; Jonas Lötscher; Maryam Akrami; Jane C. Stinchcombe; Michal A. Stanczak; Andreas Zingg; Melanie Buchi; Julien Roux; Romina Marone; Leyla Don; Didier Lardinois; Mark Wiese; Lukas T. Jeker; Mohamed Bentires-Alj; Jérémie Rossy; Daniela S. Thommen; Gillia
Published in: Nature Communications, Issue 3, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35583-w

CD4+ CAR T-cell expansion is associated with response and therapy related toxicities in patients with B-cell lymphomas

Author(s): Katharina Baur, Andreas Buser, Lukas T. Jeker, Nina Khanna, Heinz Läubli, Dominik Heim, Jan C. Dirks, Corinne C. Widmer, Thomas Volken, Jakob R. Passweg, Andreas Holbro
Published in: Bone Marrow Transplantation, Issue 58, 2023, Page(s) 1048-1050, ISSN 0268-3369
Publisher: Nature Publishing Group
DOI: 10.1038/s41409-023-02016-1

T helper cells exhibit a dynamic and reversible 3’UTR landscape

Author(s): Denis Seyres; Oliver Gorka; Ralf Schmidt; Romina Marone; Mihaela Zavolan; Lukas T. Jeker
Published in: RNA Journal, Issue 1, 2024, ISSN 1469-9001
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.19.523753

Leveraging microRNAs for cellular therapy

Author(s): Marko Hasiuk; Marianne Dölz; Romina Marone; Lukas T. Jeker
Published in: Immunology Letters, Issue 2, 2023, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2023.08.005

CRISPR/Cas-based Human T cell Engineering: Basic Research and Clinical Application

Author(s): Bettina E Bernard, Emmanuelle Landmann, Lukas T Jeker, Kathrin Schumann
Published in: Immunology Letters, 2022, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2022.03.005