Lymphatic vessel characterisation in healthy and diseased states
The goal of the EU-funded LymphMap project is to uncover the regulators of the formation and functionality of lymphatic vessels in health and disease. The project capitalises on the team's previous studies on zebrafish that revealed the cellular and molecular events in the development of the lymphatic system. These studies unveiled the origins, specification and mechanisms of the formation of lymphatic endothelial cells (LECs) in the developing embryo. The current research programme will characterise in-depth the cellular origin and molecular signature of LECs as well as the formation of organ-specific lymphatics and lymphatic vessels during regeneration and disease. The focus of the current research is on in vivo dynamics and cross-organ comparative analysis to provide knowledge on lymphatic diversity in health and disease.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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