Deciphering the metabolic roles of the urea-cycle pathway in carcinogenesis for improving diagnosis and therapy

Project Information

UreaCa

Grant agreement ID: 818943

DOI

10.3030/818943

Project closed

EC signature date 19 April 2019

Start date 1 May 2019

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

Author(s): Yarden Ariav, James H Ch’ng, Heather R. Christofk, Noga Ron-Harel, Ayelet Erez
Published in: Science Advances, Issue 7/21, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abg6165

Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

Author(s): Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-wei Shen, Nir Peled, Igor
Published in: Nature Cancer, Issue 1/9, 2020, Page(s) 894-908, ISSN 2662-1347
Publisher: Nature Cancer
DOI: 10.1038/s43018-020-0106-7

The context-specific roles of urea cycle enzymes in tumorigenesis

Author(s): Emma Hajaj, Marco Sciacovelli, Christian Frezza, Ayelet Erez
Published in: Molecular Cell, Issue 81/18, 2021, Page(s) 3749-3759, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.08.005

ASL expression in ALDH1A1+ neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype

Author(s): Shaul Lerner, Raya Eilam, Lital Adler, Julien Baruteau, Topaz Kreiser, Michael Tsoory, Alexander Brandis, Tevie Mehlman, Mina Ryten, Juan A. Botia, Sonia Garcia Ruiz, Alejandro Cisterna Garcia, Carlo Dionisi-Vici, Giusy Ranucci, Marco Spada, Ram Mazkereth, Robert McCarter, Rima Izem, Thomas J. Balmat, Rachel Richesson, Matthias R. Baumgartner, Jirair K. Bedoyan, Gerard Berry, Susan A. Berry, Peter
Published in: Human Genetics, Issue 140/10, 2021, Page(s) 1471-1485, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-021-02345-5

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Published in: Cancer Discovery, Issue 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0844