Deciphering the metabolic roles of the urea-cycle pathway in carcinogenesis for improving diagnosis and therapy

Project description

Alterations in the urea cycle in cancer

It is well established that cancer cells alter their anabolic profile to accommodate their enhanced metabolic needs for proliferation and progression. The EU-funded UreaCa project is focussing on cancer cell catabolism, and in particular the urea cycle (UC), which is responsible for nitrogen excretion. Scientists will investigate the hypothesis that cancer cells excrete less nitrogen to promote macromolecule synthesis. Through state-of-the-art omics approaches, they will study UC enzymes and associate them with particular cancer phenotypes. Results will elucidate the implication of the UC pathway in carcinogenesis and unveil novel therapeutic avenues for cancer.

Fields of science

Host institution

WEIZMANN INSTITUTE OF SCIENCE

Net EU contribution

€ 2 000 000,00

Address

Herzl Street 234
7610001 Rehovot
Israel

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Non-EU contribution

€ 0,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE

Israel