Deciphering the metabolic roles of the urea-cycle pathway in carcinogenesis for improving diagnosis and therapy

Project description

Alterations in the urea cycle in cancer

It is well established that cancer cells alter their anabolic profile to accommodate their enhanced metabolic needs for proliferation and progression. The EU-funded UreaCa project is focussing on cancer cell catabolism, and in particular the urea cycle (UC), which is responsible for nitrogen excretion. Scientists will investigate the hypothesis that cancer cells excrete less nitrogen to promote macromolecule synthesis. Through state-of-the-art omics approaches, they will study UC enzymes and associate them with particular cancer phenotypes. Results will elucidate the implication of the UC pathway in carcinogenesis and unveil novel therapeutic avenues for cancer.

Fields of science

• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › zoology › mammalogy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2018-COG - ERC Consolidator Grant

Call for proposal

ERC-2018-COG

See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

WEIZMANN INSTITUTE OF SCIENCE

Net EU contribution

€ 2 000 000,00

Address

Herzl Street 234
7610001 Rehovot
Israel

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE

Israel

Net EU contribution

€ 2 000 000,00

Address

Herzl Street 234
7610001 Rehovot

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00