Alterations in the urea cycle in cancer
It is well established that cancer cells alter their anabolic profile to accommodate their enhanced metabolic needs for proliferation and progression. The EU-funded UreaCa project is focussing on cancer cell catabolism, and in particular the urea cycle (UC), which is responsible for nitrogen excretion. Scientists will investigate the hypothesis that cancer cells excrete less nitrogen to promote macromolecule synthesis. Through state-of-the-art omics approaches, they will study UC enzymes and associate them with particular cancer phenotypes. Results will elucidate the implication of the UC pathway in carcinogenesis and unveil novel therapeutic avenues for cancer.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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