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A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?

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Publications

The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection

Author(s): Anaïs F Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Véronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, Sophie Janssens, Sabrina Marion
Published in: EMBO reports, Issue 22/3, 2021, ISSN 1469-221X
DOI: 10.15252/embr.201949617

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Author(s): Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Published in: Journal of Allergy and Clinical Immunology, Issue 144/6, 2019, Page(s) 1648-1659.e9, ISSN 0091-6749
DOI: 10.1016/j.jaci.2019.06.041

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Author(s): Eva Cloots, Nincy Debeuf, Kim Deswarte, Farzaneh Fayazpour, Manon Vanheerswynghels, Caroline De Wolf, Evelien Van De Velde, Hamida Hammad, Bart N. Lambrecht, Sven Eyckerman, Sophie Janssens
Published in: Allergy, 2021, ISSN 0105-4538
DOI: 10.1111/all.15045

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Author(s): Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
Published in: Journal of Experimental Medicine, Issue 216/9, 2019, Page(s) 2010-2023, ISSN 0022-1007
DOI: 10.1084/jem.20182164

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Author(s): Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams
Published in: Nature Neuroscience, Issue 23/5, 2020, Page(s) 676-689, ISSN 1097-6256
DOI: 10.1038/s41593-020-0618-6

Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity

Author(s): Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens, Roberto Sitia
Published in: Trends in Cell Biology, Issue 31/7, 2021, Page(s) 529-541, ISSN 0962-8924
DOI: 10.1016/j.tcb.2021.02.004

Clarifying the translational potential of B-I09

Author(s): Juan R. Del Valle, Brian C. Betts, Xue-Zhong Yu, Sophie Janssens, Bart N. Lambrecht, M. Celeste Simon, Chih-Chi Andrew Hu
Published in: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1152-1152, ISSN 1552-4450
DOI: 10.1038/s41589-020-00654-w

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Author(s): Eva Cloots, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, Michael J. Grey
Published in: Mucosal Immunology, 2021, ISSN 1933-0219
DOI: 10.1038/s41385-021-00412-8