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A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?

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The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection

Author(s): Anaïs F Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Véronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, Sophie Janssens, Sabrina Marion
Published in: EMBO reports, 22/3, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201949617

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Author(s): Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Published in: Journal of Allergy and Clinical Immunology, 144/6, 2019, Page(s) 1648-1659.e9, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.041

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Author(s): Eva Cloots, Nincy Debeuf, Kim Deswarte, Farzaneh Fayazpour, Manon Vanheerswynghels, Caroline De Wolf, Evelien Van De Velde, Hamida Hammad, Bart N. Lambrecht, Sven Eyckerman, Sophie Janssens
Published in: Allergy, 2021, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.15045

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Author(s): Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
Published in: Journal of Experimental Medicine, 216/9, 2019, Page(s) 2010-2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20182164

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Author(s): Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams
Published in: Nature Neuroscience, 23/5, 2020, Page(s) 676-689, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0618-6

Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity

Author(s): Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens, Roberto Sitia
Published in: Trends in Cell Biology, 31/7, 2021, Page(s) 529-541, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2021.02.004

Clarifying the translational potential of B-I09

Author(s): Juan R. Del Valle, Brian C. Betts, Xue-Zhong Yu, Sophie Janssens, Bart N. Lambrecht, M. Celeste Simon, Chih-Chi Andrew Hu
Published in: Nature Chemical Biology, 16/11, 2020, Page(s) 1152-1152, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-00654-w

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Author(s): Eva Cloots, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, Michael J. Grey
Published in: Mucosal Immunology, 2021, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-021-00412-8