Publications Peer reviewed articles (23) The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection Author(s): Anaïs F Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Véronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, Sophie Janssens, Sabrina Marion Published in: EMBO reports, Issue 22/3, 2021, ISSN 1469-221X Publisher: Nature Publishing Group DOI: 10.15252/embr.201949617 LXR signaling controls homeostatic dendritic cell maturation Author(s): Victor Bosteels (UGent) , Sandra Maréchal (UGent) , Clint De Nolf (UGent) , Sofie Rennen (UGent) , Jonathan Maelfait (UGent) , Simon Tavernier (UGent) , Jessica Vetters (UGent) , Evelien Van De Velde (UGent) , Farzaneh Fayazpour (UGent) , Kim Deswarte (UGent) , Alexander Lamoot (UGent) , Julie Van Duyse (UGent) , Liesbet Martens (UGent) , Cedric Bosteels (UGent) , Ria Roelandt (UGent) , Annelies Published in: Science Immunology, 2023, ISSN 2470-9468 Publisher: Science DOI: 10.1126/sciimmunol.add3955 The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice Author(s): Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht Published in: Journal of Allergy and Clinical Immunology, Issue 144/6, 2019, Page(s) 1648-1659.e9, ISSN 0091-6749 Publisher: Mosby Inc. DOI: 10.1016/j.jaci.2019.06.041 Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2 Author(s): Eva Cloots, Phaedra Guilbert, Mathias Provost M, Lisa Neidhardt, Evelien Van De Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas Savvides, Sven Eyckerman, Sophie Janssens Published in: The EMBO Journal, Issue 43, 2023, Page(s) 695-718, ISSN 0261-4189 Publisher: Nature Publishing Group DOI: 10.1038/s44318-023-00015-y TIM3+ TRBV11-2 T cells and IFNg signature in patrolling monocytes and CD16+ NK cells delineate MIS-C Author(s): Simon Tavernier, Levi Hoste, Lisa Roels, Leslie Naesens, Victor Bosteels,..., Sophie Janssens, Rudi Beyaert,Yvan Saeys, Jean-Laurent Casanova, Bart Lambrecht, Filomeen Haerynck Published in: The journal of experimental medicine, Issue 219, 2021, ISSN 0022-1007 Publisher: Rockefeller University Press DOI: 10.1084/jem.20211381 Type 1 immunity enables neonatal thymic ILC1 production Author(s): Peter Tougaard, Mario Pérez, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, Sophie Janssens, Terkild Buus, Tom Taghon, Georges Leclercq and Peter Vandenabeele Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548 Publisher: AAAS DOI: 10.1126/sciadv.adh5520 The STE-20 kinase TAOK3 controls the development HDM-induced asthma in mice Author(s): Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, Benjamin Pavie, Wendy Toussaint, Sophie Janssens, Savvas Savvides, Bart Lambrecht, and Hamida Hammad Published in: Journal of Allergy and Clinical Immunology, Issue 149, 2021, Page(s) 1413-1427, ISSN 0091-6749 Publisher: Mosby Inc. DOI: 10.1016/j.jaci.2021.08.020 ER stress in antigen presenting cells promotes NKT cell activation through endogenous neutral lipids Author(s): Srinath Govindarajan, Eveline Verheugen, Koen Venken, Djoere Gaublomme, Eva Cloots, Fien Gysens, Bruno De Geest, Tan-Yun Cheng, D Branch Moody, Sophie Janssens, Michael Drennan, Dirk Elewaut Published in: EMBO reports, Issue 21, 2020, ISSN 1469-221x Publisher: Nature Publishing Group DOI: 10.15252/embr.201948927 IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model Author(s): Eva Cloots, Nincy Debeuf, Kim Deswarte, Farzaneh Fayazpour, Manon Vanheerswynghels, Caroline De Wolf, Evelien Van De Velde, Hamida Hammad, Bart N. Lambrecht, Sven Eyckerman, Sophie Janssens Published in: Allergy, 2021, ISSN 0105-4538 Publisher: Blackwell Publishing Inc. DOI: 10.1111/all.15045 The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF Author(s): Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens Published in: Journal of Experimental Medicine, Issue 216/9, 2019, Page(s) 2010-2023, ISSN 0022-1007 Publisher: Rockefeller University Press DOI: 10.1084/jem.20182164 Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown Author(s): Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadege Wadier, Sandra Maréchal, Clint De Nolf, V,..., Sophie Janssens, Pauline Soulas-Sprauel Published in: Journal of Autoimmunity, Issue 142, 2023, ISSN 0896-8411 Publisher: Academic Press DOI: 10.1016/j.jaut.2023.103152 The IRE1 inhibitor Kira6 curtails the inflammatory trait of immunogenic anticancer treatments by targeting Hsp60 independent of IRE1 Author(s): Nicole Rufo, Dimitris Korovesis, Sofie Van Eygen, Rita Derua, Abhishek Garg, Francesca Finotello, Monica Vara Perez, Jan Rozanc, Michael Dewaele, Peter de Witte, Leonidas Alexopoulos, Sophie Janssens, Lasse Sinkkonen, Thomas Sauter, Steven Verhelst, and Patrizia Agostinis Published in: Cell Death & Differentiation, Issue 29, 2022, Page(s) 230-245, ISSN 1350-9047 Publisher: Nature Publishing Group DOI: 10.1038/s41418-021-00853-5 The IRE1b-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells Author(s): Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline Weiss, Heather Harding, Stephen McLaughlin, Sophie Janssens, David Ron Published in: The EMBO Journal, Issue 43, 2023, Page(s) 719-753, ISSN 0261-4189 Publisher: Nature Publishing Group DOI: 10.1038/s44318-023-00014-z A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism Author(s): Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo Published in: Cell Reports, Issue 36, 2021, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2021.109748 TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization Author(s): Zan Li, Hwanhee Oh, Michelle Cung, Sofie Jenia Marquez, Jun Sun, Hamida Hammad, Sophie Janssens, Philippe Pouliot, Bart Lambrecht, Yeon-Suk Yang, Jae-Huyck Shim, and Matthew Greenblatt Published in: Biochemical and Biophysical Research Communications, Issue 4, 2020, Page(s) 497-502, ISSN 0006-291X Publisher: Academic Press DOI: 10.1016/j.bbrc.2020.07.060 Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury Author(s): Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams Published in: Nature Neuroscience, Issue 23/5, 2020, Page(s) 676-689, ISSN 1097-6256 Publisher: Nature Publishing Group DOI: 10.1038/s41593-020-0618-6 Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity Author(s): Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens, Roberto Sitia Published in: Trends in Cell Biology, Issue 31/7, 2021, Page(s) 529-541, ISSN 0962-8924 Publisher: Elsevier BV DOI: 10.1016/j.tcb.2021.02.004 Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity Author(s): Felipe Flores-Santibañez; Sofie Rennen; Dominique Fernández; Clint De Nolf; Evelien Van De Velde; Sandra Gaete González; Camila Fuentes; Carolina Moreno; Diego Figueroa; Álvaro Lladser; Takao Iwawaki; María Rosa Bono; Sophie Janssens; Fabiola Osorio Published in: Frontiers in Immunology, Issue 4, 2023, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2023.1209588 Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection Author(s): Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Manon Vanheerswynghels, Justine Van Moorleghem, Karl Vergote, Louis Boon, Eric Vivier, Bart Lambrecht and Sophie Janssens Published in: iScience, Issue 26, 2023, ISSN 2589-0042 Publisher: Cell Press DOI: 10.1016/j.isci.2023.108570 Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages Author(s): Aleksandar Murgaski, Maté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse J, Eva Hadadi, Jan Brughmans, Sana Arnouk, Ahmed Hamouda, Ayla Debraekeleer, Victor Bosteels, Yvon Elkrim, Louis Boon, Sabine Hoves, Niels Vandamme, Sofie Deschoemaeker, Sophie Janssens, Abhishek Garg, Martina Schmittnaegel, Carola Ries, and Damya Laoui Published in: Cancer Research, Issue 82, 2022, Page(s) 3785-3801, ISSN 0008-5472 Publisher: American Association for Cancer Research DOI: 10.1158/0008-5472.can-22-0094 Clarifying the translational potential of B-I09 Author(s): Juan R. Del Valle, Brian C. Betts, Xue-Zhong Yu, Sophie Janssens, Bart N. Lambrecht, M. Celeste Simon, Chih-Chi Andrew Hu Published in: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1152-1152, ISSN 1552-4450 Publisher: Nature Publishing Group DOI: 10.1038/s41589-020-00654-w STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity Author(s): Bastiaan Maes; Farzaneh Fayazpour; Leen Catrysse; Guillaume Lornet; Evelien Van De Velde; Caroline De Wolf; Sofie De Prijck; Justine Van Moorleghem; Manon Vanheerswynghels; Kim Deswarte; Benedicte Descamps; Christian Vanhove; Bart Van der Schueren; Roman Vangoitsenhoven; Hamida Hammad; Sophie Janssens; Bart N. Lambrecht Published in: Journal of Experimental Medicine, Issue 8, 2023, ISSN 1540-9538 Publisher: Journal of Experimental Medicine DOI: 10.1084/jem.20210788 Evolution and function of the epithelial cell-specific ER stress sensor IRE1β Author(s): Eva Cloots, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, Michael J. Grey Published in: Mucosal Immunology, 2021, ISSN 1933-0219 Publisher: Nature Publishing Group DOI: 10.1038/s41385-021-00412-8 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
