A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?

Project Information

DCRIDDLE

Grant agreement ID: 819314

DOI 10.3030/819314

Project closed

EC signature date 28 January 2019

Start date 1 February 2019

End date 31 January 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 196,00

EU contribution € 1 999 196,00

Coordinated by

VIB VZW
Belgium

Publications

Peer reviewed articles (23)

The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection

Author(s): Anaïs F Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Véronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, Sophie Janssens, Sabrina Marion
Published in: EMBO reports, Issue 22/3, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201949617

LXR signaling controls homeostatic dendritic cell maturation

Author(s): Victor Bosteels (UGent) , Sandra Maréchal (UGent) , Clint De Nolf (UGent) , Sofie Rennen (UGent) , Jonathan Maelfait (UGent) , Simon Tavernier (UGent) , Jessica Vetters (UGent) , Evelien Van De Velde (UGent) , Farzaneh Fayazpour (UGent) , Kim Deswarte (UGent) , Alexander Lamoot (UGent) , Julie Van Duyse (UGent) , Liesbet Martens (UGent) , Cedric Bosteels (UGent) , Ria Roelandt (UGent) , Annelies
Published in: Science Immunology, 2023, ISSN 2470-9468
Publisher: Science
DOI: 10.1126/sciimmunol.add3955

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Author(s): Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Published in: Journal of Allergy and Clinical Immunology, Issue 144/6, 2019, Page(s) 1648-1659.e9, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.041

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Author(s): Eva Cloots, Phaedra Guilbert, Mathias Provost M, Lisa Neidhardt, Evelien Van De Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas Savvides, Sven Eyckerman, Sophie Janssens
Published in: The EMBO Journal, Issue 43, 2023, Page(s) 695-718, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.1038/s44318-023-00015-y

TIM3+ TRBV11-2 T cells and IFNg signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Author(s): Simon Tavernier, Levi Hoste, Lisa Roels, Leslie Naesens, Victor Bosteels,..., Sophie Janssens, Rudi Beyaert,Yvan Saeys, Jean-Laurent Casanova, Bart Lambrecht, Filomeen Haerynck
Published in: The journal of experimental medicine, Issue 219, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20211381

Type 1 immunity enables neonatal thymic ILC1 production

Author(s): Peter Tougaard, Mario Pérez, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, Sophie Janssens, Terkild Buus, Tom Taghon, Georges Leclercq and Peter Vandenabeele
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.adh5520

The STE-20 kinase TAOK3 controls the development HDM-induced asthma in mice

Author(s): Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, Benjamin Pavie, Wendy Toussaint, Sophie Janssens, Savvas Savvides, Bart Lambrecht, and Hamida Hammad
Published in: Journal of Allergy and Clinical Immunology, Issue 149, 2021, Page(s) 1413-1427, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2021.08.020

ER stress in antigen presenting cells promotes NKT cell activation through endogenous neutral lipids

Author(s): Srinath Govindarajan, Eveline Verheugen, Koen Venken, Djoere Gaublomme, Eva Cloots, Fien Gysens, Bruno De Geest, Tan-Yun Cheng, D Branch Moody, Sophie Janssens, Michael Drennan, Dirk Elewaut
Published in: EMBO reports, Issue 21, 2020, ISSN 1469-221x
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201948927

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Author(s): Eva Cloots, Nincy Debeuf, Kim Deswarte, Farzaneh Fayazpour, Manon Vanheerswynghels, Caroline De Wolf, Evelien Van De Velde, Hamida Hammad, Bart N. Lambrecht, Sven Eyckerman, Sophie Janssens
Published in: Allergy, 2021, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.15045

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Author(s): Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
Published in: Journal of Experimental Medicine, Issue 216/9, 2019, Page(s) 2010-2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20182164

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown

Author(s): Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadege Wadier, Sandra Maréchal, Clint De Nolf, V,..., Sophie Janssens, Pauline Soulas-Sprauel
Published in: Journal of Autoimmunity, Issue 142, 2023, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2023.103152

The IRE1 inhibitor Kira6 curtails the inflammatory trait of immunogenic anticancer treatments by targeting Hsp60 independent of IRE1

Author(s): Nicole Rufo, Dimitris Korovesis, Sofie Van Eygen, Rita Derua, Abhishek Garg, Francesca Finotello, Monica Vara Perez, Jan Rozanc, Michael Dewaele, Peter de Witte, Leonidas Alexopoulos, Sophie Janssens, Lasse Sinkkonen, Thomas Sauter, Steven Verhelst, and Patrizia Agostinis
Published in: Cell Death & Differentiation, Issue 29, 2022, Page(s) 230-245, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00853-5

The IRE1b-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Author(s): Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline Weiss, Heather Harding, Stephen McLaughlin, Sophie Janssens, David Ron
Published in: The EMBO Journal, Issue 43, 2023, Page(s) 719-753, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.1038/s44318-023-00014-z

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Author(s): Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Published in: Cell Reports, Issue 36, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109748

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization

Author(s): Zan Li, Hwanhee Oh, Michelle Cung, Sofie Jenia Marquez, Jun Sun, Hamida Hammad, Sophie Janssens, Philippe Pouliot, Bart Lambrecht, Yeon-Suk Yang, Jae-Huyck Shim, and Matthew Greenblatt
Published in: Biochemical and Biophysical Research Communications, Issue 4, 2020, Page(s) 497-502, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2020.07.060

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Author(s): Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams
Published in: Nature Neuroscience, Issue 23/5, 2020, Page(s) 676-689, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0618-6

Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity

Author(s): Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens, Roberto Sitia
Published in: Trends in Cell Biology, Issue 31/7, 2021, Page(s) 529-541, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2021.02.004

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Author(s): Felipe Flores-Santibañez; Sofie Rennen; Dominique Fernández; Clint De Nolf; Evelien Van De Velde; Sandra Gaete González; Camila Fuentes; Carolina Moreno; Diego Figueroa; Álvaro Lladser; Takao Iwawaki; María Rosa Bono; Sophie Janssens; Fabiola Osorio
Published in: Frontiers in Immunology, Issue 4, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1209588

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Author(s): Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Manon Vanheerswynghels, Justine Van Moorleghem, Karl Vergote, Louis Boon, Eric Vivier, Bart Lambrecht and Sophie Janssens
Published in: iScience, Issue 26, 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.108570

Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages

Author(s): Aleksandar Murgaski, Maté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse J, Eva Hadadi, Jan Brughmans, Sana Arnouk, Ahmed Hamouda, Ayla Debraekeleer, Victor Bosteels, Yvon Elkrim, Louis Boon, Sabine Hoves, Niels Vandamme, Sofie Deschoemaeker, Sophie Janssens, Abhishek Garg, Martina Schmittnaegel, Carola Ries, and Damya Laoui
Published in: Cancer Research, Issue 82, 2022, Page(s) 3785-3801, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-0094

Clarifying the translational potential of B-I09

Author(s): Juan R. Del Valle, Brian C. Betts, Xue-Zhong Yu, Sophie Janssens, Bart N. Lambrecht, M. Celeste Simon, Chih-Chi Andrew Hu
Published in: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1152-1152, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-00654-w

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Author(s): Bastiaan Maes; Farzaneh Fayazpour; Leen Catrysse; Guillaume Lornet; Evelien Van De Velde; Caroline De Wolf; Sofie De Prijck; Justine Van Moorleghem; Manon Vanheerswynghels; Kim Deswarte; Benedicte Descamps; Christian Vanhove; Bart Van der Schueren; Roman Vangoitsenhoven; Hamida Hammad; Sophie Janssens; Bart N. Lambrecht
Published in: Journal of Experimental Medicine, Issue 8, 2023, ISSN 1540-9538
Publisher: Journal of Experimental Medicine
DOI: 10.1084/jem.20210788

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Author(s): Eva Cloots, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, Michael J. Grey
Published in: Mucosal Immunology, 2021, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-021-00412-8