Project description
IRE1 as a switch between tolerogenic and immunogenic responses
Dendritic cells (DCs) function as gatekeepers of the immune system, coordinating the balance between immunity and tolerance to self-antigens. The switch between the two states remains one of the most puzzling questions in immunology. Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER) protein and the component of the unfolded protein response pathway for sensing and responding to ER stress. IRE1 contains an ER luminal stress-sensing domain and a cytoplasmic RNase domain. The aim of the EU-funded DCRIDDLE project is to determine if IRE1 in DCs is the switch between tolerogenic and immunogenic maturation. Apart from its impact on the field of DC biology, this research will bring a new understanding of autoimmunity, graft versus host disease and all conditions characterised by an imbalance between tolerogenic and immunogenic responses.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator GrantHost institution
9052 Zwijnaarde - Gent
Belgium
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Beneficiaries (1)
9052 Zwijnaarde - Gent
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