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A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?

Project description

IRE1 as a switch between tolerogenic and immunogenic responses

Dendritic cells (DCs) function as gatekeepers of the immune system, coordinating the balance between immunity and tolerance to self-antigens. The switch between the two states remains one of the most puzzling questions in immunology. Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER) protein and the component of the unfolded protein response pathway for sensing and responding to ER stress. IRE1 contains an ER luminal stress-sensing domain and a cytoplasmic RNase domain. The aim of the EU-funded DCRIDDLE project is to determine if IRE1 in DCs is the switch between tolerogenic and immunogenic maturation. Apart from its impact on the field of DC biology, this research will bring a new understanding of autoimmunity, graft versus host disease and all conditions characterised by an imbalance between tolerogenic and immunogenic responses.

Host institution

VIB VZW
Net EU contribution
€ 1 999 196,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 1 999 196,00

Beneficiaries (1)

VIB VZW
Belgium
Net EU contribution
€ 1 999 196,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

See on map

Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 1 999 196,00