A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?

Publicaciones

The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection

Autores: Anaïs F Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Véronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, Sophie Janssens, Sabrina Marion
Publicado en: EMBO reports, Edición 22/3, 2021, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201949617

LXR signaling controls homeostatic dendritic cell maturation

Autores: Victor Bosteels (UGent) , Sandra Maréchal (UGent) , Clint De Nolf (UGent) , Sofie Rennen (UGent) , Jonathan Maelfait (UGent) , Simon Tavernier (UGent) , Jessica Vetters (UGent) , Evelien Van De Velde (UGent) , Farzaneh Fayazpour (UGent) , Kim Deswarte (UGent) , Alexander Lamoot (UGent) , Julie Van Duyse (UGent) , Liesbet Martens (UGent) , Cedric Bosteels (UGent) , Ria Roelandt (UGent) , Annelies
Publicado en: Science Immunology, 2023, ISSN 2470-9468
Editor: Science
DOI: 10.1126/sciimmunol.add3955

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Autores: Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Publicado en: Journal of Allergy and Clinical Immunology, Edición 144/6, 2019, Página(s) 1648-1659.e9, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.041

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Autores: Eva Cloots, Phaedra Guilbert, Mathias Provost M, Lisa Neidhardt, Evelien Van De Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas Savvides, Sven Eyckerman, Sophie Janssens
Publicado en: The EMBO Journal, Edición 43, 2023, Página(s) 695-718, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.1038/s44318-023-00015-y

TIM3+ TRBV11-2 T cells and IFNg signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Autores: Simon Tavernier, Levi Hoste, Lisa Roels, Leslie Naesens, Victor Bosteels,..., Sophie Janssens, Rudi Beyaert,Yvan Saeys, Jean-Laurent Casanova, Bart Lambrecht, Filomeen Haerynck
Publicado en: The journal of experimental medicine, Edición 219, 2021, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20211381

Type 1 immunity enables neonatal thymic ILC1 production

Autores: Peter Tougaard, Mario Pérez, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, Sophie Janssens, Terkild Buus, Tom Taghon, Georges Leclercq and Peter Vandenabeele
Publicado en: Science Advances, Edición 10, 2024, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.adh5520

The STE-20 kinase TAOK3 controls the development HDM-induced asthma in mice

Autores: Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, Benjamin Pavie, Wendy Toussaint, Sophie Janssens, Savvas Savvides, Bart Lambrecht, and Hamida Hammad
Publicado en: Journal of Allergy and Clinical Immunology, Edición 149, 2021, Página(s) 1413-1427, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2021.08.020

ER stress in antigen presenting cells promotes NKT cell activation through endogenous neutral lipids

Autores: Srinath Govindarajan, Eveline Verheugen, Koen Venken, Djoere Gaublomme, Eva Cloots, Fien Gysens, Bruno De Geest, Tan-Yun Cheng, D Branch Moody, Sophie Janssens, Michael Drennan, Dirk Elewaut
Publicado en: EMBO reports, Edición 21, 2020, ISSN 1469-221x
Editor: Nature Publishing Group
DOI: 10.15252/embr.201948927

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Autores: Eva Cloots, Nincy Debeuf, Kim Deswarte, Farzaneh Fayazpour, Manon Vanheerswynghels, Caroline De Wolf, Evelien Van De Velde, Hamida Hammad, Bart N. Lambrecht, Sven Eyckerman, Sophie Janssens
Publicado en: Allergy, 2021, ISSN 0105-4538
Editor: Blackwell Publishing Inc.
DOI: 10.1111/all.15045

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Autores: Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
Publicado en: Journal of Experimental Medicine, Edición 216/9, 2019, Página(s) 2010-2023, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20182164

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown

Autores: Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadege Wadier, Sandra Maréchal, Clint De Nolf, V,..., Sophie Janssens, Pauline Soulas-Sprauel
Publicado en: Journal of Autoimmunity, Edición 142, 2023, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2023.103152

The IRE1 inhibitor Kira6 curtails the inflammatory trait of immunogenic anticancer treatments by targeting Hsp60 independent of IRE1

Autores: Nicole Rufo, Dimitris Korovesis, Sofie Van Eygen, Rita Derua, Abhishek Garg, Francesca Finotello, Monica Vara Perez, Jan Rozanc, Michael Dewaele, Peter de Witte, Leonidas Alexopoulos, Sophie Janssens, Lasse Sinkkonen, Thomas Sauter, Steven Verhelst, and Patrizia Agostinis
Publicado en: Cell Death & Differentiation, Edición 29, 2022, Página(s) 230-245, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00853-5

The IRE1b-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Autores: Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline Weiss, Heather Harding, Stephen McLaughlin, Sophie Janssens, David Ron
Publicado en: The EMBO Journal, Edición 43, 2023, Página(s) 719-753, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.1038/s44318-023-00014-z

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Autores: Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Publicado en: Cell Reports, Edición 36, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109748

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization

Autores: Zan Li, Hwanhee Oh, Michelle Cung, Sofie Jenia Marquez, Jun Sun, Hamida Hammad, Sophie Janssens, Philippe Pouliot, Bart Lambrecht, Yeon-Suk Yang, Jae-Huyck Shim, and Matthew Greenblatt
Publicado en: Biochemical and Biophysical Research Communications, Edición 4, 2020, Página(s) 497-502, ISSN 0006-291X
Editor: Academic Press
DOI: 10.1016/j.bbrc.2020.07.060

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Autores: Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams
Publicado en: Nature Neuroscience, Edición 23/5, 2020, Página(s) 676-689, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-020-0618-6

Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity

Autores: Eelco van Anken, Anush Bakunts, Chih-Chi Andrew Hu, Sophie Janssens, Roberto Sitia
Publicado en: Trends in Cell Biology, Edición 31/7, 2021, Página(s) 529-541, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2021.02.004

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Autores: Felipe Flores-Santibañez; Sofie Rennen; Dominique Fernández; Clint De Nolf; Evelien Van De Velde; Sandra Gaete González; Camila Fuentes; Carolina Moreno; Diego Figueroa; Álvaro Lladser; Takao Iwawaki; María Rosa Bono; Sophie Janssens; Fabiola Osorio
Publicado en: Frontiers in Immunology, Edición 4, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1209588

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Autores: Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Manon Vanheerswynghels, Justine Van Moorleghem, Karl Vergote, Louis Boon, Eric Vivier, Bart Lambrecht and Sophie Janssens
Publicado en: iScience, Edición 26, 2023, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2023.108570

Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages

Autores: Aleksandar Murgaski, Maté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse J, Eva Hadadi, Jan Brughmans, Sana Arnouk, Ahmed Hamouda, Ayla Debraekeleer, Victor Bosteels, Yvon Elkrim, Louis Boon, Sabine Hoves, Niels Vandamme, Sofie Deschoemaeker, Sophie Janssens, Abhishek Garg, Martina Schmittnaegel, Carola Ries, and Damya Laoui
Publicado en: Cancer Research, Edición 82, 2022, Página(s) 3785-3801, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-0094

Clarifying the translational potential of B-I09

Autores: Juan R. Del Valle, Brian C. Betts, Xue-Zhong Yu, Sophie Janssens, Bart N. Lambrecht, M. Celeste Simon, Chih-Chi Andrew Hu
Publicado en: Nature Chemical Biology, Edición 16/11, 2020, Página(s) 1152-1152, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-00654-w

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Autores: Bastiaan Maes; Farzaneh Fayazpour; Leen Catrysse; Guillaume Lornet; Evelien Van De Velde; Caroline De Wolf; Sofie De Prijck; Justine Van Moorleghem; Manon Vanheerswynghels; Kim Deswarte; Benedicte Descamps; Christian Vanhove; Bart Van der Schueren; Roman Vangoitsenhoven; Hamida Hammad; Sophie Janssens; Bart N. Lambrecht
Publicado en: Journal of Experimental Medicine, Edición 8, 2023, ISSN 1540-9538
Editor: Journal of Experimental Medicine
DOI: 10.1084/jem.20210788

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Autores: Eva Cloots, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, Michael J. Grey
Publicado en: Mucosal Immunology, 2021, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1038/s41385-021-00412-8

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