Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Project Information

ADIMMUNE

Grant agreement ID: 819439

DOI

10.3030/819439

Project closed

EC signature date 20 February 2019

Start date 1 March 2019

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Embrace the fat when getting old

Author(s): Lorenz Adlung, Ido Amit, Eran Elinav
Published in: Aging, Issue 11/20, 2019, Page(s) 8730-8732, ISSN 1945-4589
Publisher: Aging
DOI: 10.18632/aging.102341

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Author(s): Anthony T. Virtue, Sam J. McCright, Jasmine M. Wright, Monica T. Jimenez, Walter K. Mowel, Jonathan J. Kotzin, Leonel Joannas, Megha G. Basavappa, Sean P. Spencer, Megan L. Clark, Stephen H. Eisennagel, Adam Williams, Maayan Levy, Sasikanth Manne, Sarah E. Henrickson, E. John Wherry, Christoph A. Thaiss, Eran Elinav, Jorge Henao-Mejia
Published in: Science Translational Medicine, Issue 11/496, 2019, Page(s) eaav1892, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aav1892

A non-antibiotic-disrupted gut microbiome predicts clinical responses to CD19-targeted CAR-T cell immunotherapy across international cohorts

Author(s): Stein-Thoeringer CK, Saini NY, Zamir E, Blumenberg V, Schubert ML, Mor U, Fante MA, Schmidt S, Hayase E, Hayase T, Rohrbach R, Chang CC, Macdaniel L, Flores I, Gaiser R, Edinger M, Wolff D, Heidenreich M, Strati P, Nair R, Chihara D, Fayad L, Ahmed S, Iyer SP, Steiner R, Jain P, Nastoupil L, Westin J, Arora R, Wang M, Turner J, Menges M, Hidalgo-Vargas M, Reid K, Dreger P, Schmit A, Müller-Tidow
Published in: Nature Medicine, Issue 42(1):111981, 2023, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02234-6

Diet–microbiota interactions and personalized nutrition

Author(s): Aleksandra A. Kolodziejczyk, Danping Zheng, Eran Elinav
Published in: Nature Reviews Microbiology, Issue 17/12, 2019, Page(s) 742-753, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-019-0256-8

Nutrition Regulates Innate Immunity in Health and Disease

Author(s): Samuel Philip Nobs , Niv Zmora , Eran Elinav
Published in: Annu Rev Nutr., Issue 2020 Sep, 2020, ISSN 1545-4312
Publisher: Annu Rev Nutr.
DOI: 10.1146/annurev-nutr-120919-094440

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Author(s): Diego Adhemar Jaitin, Lorenz Adlung, Christoph A. Thaiss, Assaf Weiner, Baoguo Li, Hélène Descamps, Patrick Lundgren, Camille Bleriot, Zhaoyuan Liu, Aleksandra Deczkowska, Hadas Keren-Shaul, Eyal David, Niv Zmora, Shai Meron Eldar, Nir Lubezky, Oren Shibolet, David A. Hill, Mitchell A. Lazar, Marco Colonna, Florent Ginhoux, Hagit Shapiro, Eran Elinav, Ido Amit
Published in: Cell, Issue 178/3, 2019, Page(s) 686-698.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.05.054

Acute liver failure is regulated by MYC- and microbiome-dependent programs

Author(s): Kolodziejczyk AA, Federici S, Zmora N, Mohapatra G, Dori-Bachash M,Hornstein S, Leshem A, Reuveni D, Zigmond E, Tobar A, Salame TM, Harmelin A, Shlomai A, Shpiro H, Amit I, Elinav E.
Published in: nature medicine, Issue 26, (2020), 2020, Page(s) pages 1899–1911, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-1102-2

Diabetic susceptibility to pulmonary viral infection is driven by an impaired metabolic-epigenetic lung dendritic cell function

Author(s): Nobs SP, Kolodziejczyk AA, Adler L, HoresH N, Botscharnikow C, Herzog E, Mohapatra G, Hejndorf S, Hodgetts RJ, Spivak I, Schorr L, Fluhr L, Kviatcovsky D, Zacharia A7, Stettner N, Dori-Bachash M, Harmelin A, Brandis A, Mehlman T, Erez A, He Y, Ferrini S, Puschhof J, Shapiro H, Kopf M, Moussaieff A, Abdeen SK,
Published in: Nature, Issue 624(7992, 2023, Page(s) 645–652., ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06803-0

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

Author(s): Suez J, Cohen Y, Valdés-Mas R, Mor U, Dori-Bachash M, Federici S, Zmora N, Leshem A, Heinemann M, Zur M, Ben-Zeev Brik R, Bukimer A, Eliyahu-Miller S, Metz A, Fischbein R, Sharov O, Malitsky S, Itkin M, Stettner N, Harmelin A, Shapiro H, Stein-Thoeringer CK, Segal E, Elinav E.
Published in: Cell, Issue Sep 2022, 2022, Page(s) 3307-3328, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.016

Epithelial Nlrp10 inflammasome mediates protection against intestinal auto-inflammation.

Author(s): Zheng D, Mohapatra G, Kern L, He Y, Shmueli MD, Valdés-Mas R, Kolodziejczyk A, Próchnicki T, Vasconcelos MB, Schorr L, Hertel F, Lee YS, Rufino MC, Ceddaha E, Shimshy S, Hodgetts RJ, Dori-Bachash M, Kleimeyer C, Goldenberg K, Heinemann M, Stettner N, Harmelin A, Shapiro H, Puschhof J, Chen M, Flavell RA, Latz E, Merbl Y, Abdeen SK, Elinav E.
Published in: Nature Immunology, Issue 20 March, 2023, Page(s) 24(4):585-94, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01450-z

Gut microbiota modulates weight gain in mice after discontinued smoke exposure

Author(s): Fluhr L, Mor U, Kolodziejczyk AA, Dori-Bachash M, Leshem A, Itav S, Cohen Y, Suez Z, Molina S, Ayalon N, Valdes-Mas R, Hornstein S, Karbi H, Kviatcovsky D, Livne A, Bukimer A, Eliyahu-Miller S, Metz A, Brandis A, Mehlman T, Kuperman Y, Tsoory M, Stettner N, Harmelin A, Shapiro H, Elinav E.
Published in: Nature, Issue 08 Dec 2021, 2021, Page(s) 713–719, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04194-8

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

Author(s): Federici S, Kredo-Russo S, Valdés-Mas R, Kviatcovsky D, Weinstock E, Matiuhin Y, Silberberg Y, Atarashi K, Furuichi M, Oka A, Liu B, Fibelman M, Weiner IN, Khabra E, Cullin N, Ben-Yishai N, Inbar D, Ben-David H, Nicenboim J, Kowalsman N, Lieb W, Kario2, Cohen ET, Geffen YF, Zelcbuch L, Cohen A, Rappo U, Gahali-Sass I, Golembo M, Lev V, Dori-Bachash M, Shapiro H, Moresi C, Cuevas-Sierra A, Mohapat
Published in: Cell, Issue AUG 04 2022, 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.003