Skip to main content

Understanding host cellular systems that drive an endosymbiotic interaction

Project description

Molecular mechanisms of endosymbiosis

Endosymbiosis is the phenomenon of integration of one cell within another to become a critical component of the recipient, changing its characteristics and creating a novel evolutionary trajectory. Paramecium bursaria is a single-cell protist with multiple green algae within, forming a phototrophic endosymbiosis. This relationship is nascent, and the partners can be separated and grown separately with the subsequent reinitiation of endosymbiosis. The EU-funded CELL-in-CELL project will identify, for the first time, the gene functions responsible for stable endosymbiotic interaction. To identify host genes determining endosymbiosis in P. bursaria, researchers developed RNAi silencing technology. They will conduct genome sequencing, followed by a large-scale RNAi knockdown screening experiment to identify host genes and proteins involved in the endosymbiosis process.

Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 2 510 270,76
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

See on map

Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 2 510 270,76
Address
Wellington Square University Offices
OX1 2JD Oxford

See on map

Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE UNIVERSITY OF EXETER

Participation ended

United Kingdom
Net EU contribution
€ 92 212,24
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Region
South West (England) Devon Devon CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00