Imaging Biomolecular Self-Assembly with a Molecular Photonic Scale

Project description

Imaging of biomolecular interactions at the single-molecule level

The EU-funded PHOTOMASS project aims to shed light on biomolecular interactions and self-assembly via direct visualisation of the molecular mechanisms. The research will capitalise on the recent development of mass photometry (MP) by the project partners. MP enables the detection and imaging of single biomolecules in solution as well as the determination of their molecular mass at the single-molecule level. This technology merges the high-resolution structural and low-resolution solution-based methods for studies of biomolecular interactions and assembly. The project leads to a broad range of applications, visualising the mechanism of viral capsid assembly, cytoskeletal dynamics, the amyloid aggregation, and others beyond molecular biophysics.

Fields of science

• natural sciences › chemical sciences › analytical chemistry › mass spectrometry

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2018-COG - ERC Consolidator Grant

Call for proposal

ERC-2018-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 999 574

Beneficiaries (1)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU contribution

€ 1 999 574

Address

Wellington Square University Offices
OX1 2JD Oxford

Activity type

Higher or Secondary Education Establishments