Genome-wide surveys and functional analysis of pancreatic cancer metastasis drivers

Project Information

PACA-MET

Grant agreement ID: 819642

DOI

10.3030/819642

Project closed

EC signature date 19 February 2019

Start date 1 November 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 875,00

EU contribution

€ 1 995 875,00

Coordinated by

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Author(s): Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Len
Published in: Nature, Issue 554, 2022, Page(s) 62-68, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature25459

Tutorial: design and execution of CRISPR in vivo screens.

Author(s): Braun CJ, Adames AC, Saur D, Rad R
Published in: Nature Protocols, 2022, ISSN 1754-2189
Publisher: Nature Publishing Group

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Author(s): Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juan José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J. Swietlik, Jing-Yuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Zukowska, Angelica Arenas Vargas, Woo Hyun Paik, Mo
Published in: Nature Cancer, Issue 3, 2022, Page(s) 318-336, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43018-021-00326-1

In vivo functional screening for systems-level integrative cancer genomics

Author(s): Julia Weber, Christian J. Braun, Dieter Saur, Roland Rad
Published in: Nature Reviews Cancer, Issue 20, 2023, Page(s) 573-593, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-020-0275-9

Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy

Author(s): Stefanie Bärthel, Chiara Falcomatà, Roland Rad, Fabian J. Theis, Dieter Saur
Published in: Nature Cancer, Issue 4, 2023, Page(s) 454-467, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43018-023-00526-x

CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver

Author(s): Kaltenbacher T, Löprich J, Maresch R, Weber J, Müller S, Oellinger R, Groß N, Griger J, de Andrade Krätzig N, Avramopoulos P, Ramanujam D, Brummer S, Widholz SA, Bärthel S, Falcomatà C, Pfaus A, Alnatsha A, Mayerle J, Schmidt-Supprian M, Reichert M, Schneider G, Ehmer U, Braun CJ, Saur D, Engelhardt S, Rad R
Published in: Nature protocols, 2022, ISSN 1754-2189
Publisher: Nature Publishing Group

Engineering CRISPR mouse models of cancer

Author(s): Julia Weber, Roland Rad
Published in: Current Opinion in Genetics & Development, Issue 54, 2019, Page(s) 88-96, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2019.04.001

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer

Author(s): Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp, Lena Rad, Fabio Boniolo, Myriam Solar, Katja Steiger, Barbara Seidler, Magdalena Zukowska, Joanna Madej, Mingsong Wang, Rupert Öllinger, Roman Maresch, Maxim Barenboim, Stefan Eser, Markus Tschurtschenthaler, Arianeb Mehrabi, Stephanie Roessler, Benjamin Goeppert, Alexander Kind, Angelika Schnieke, Maria S.
Published in: Cancer Discovery, Issue 11, 2023, Page(s) 3158-3177, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-0209

In vivo functional screening for systems-level integrative cancer genomics.

Author(s): Weber J, Braun CJ, Saur D, Rad R
Published in: Nature Reviews Cancer, 2020, ISSN 1474-175X
Publisher: Nature Publishing Group

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses

Author(s): Sebastian Mueller, Sebastian Lange, Katharina A. N. Collins, Stefan Krebs, Helmut Blum, Günter Schneider, Lena Rad, Dieter Saur, Roland Rad
Published in: Nature Communications, Issue 11, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18095-3

Tutorial: design and execution of CRISPR in vivo screens

Author(s): Christian J. Braun, Andrés Carbonell Adames, Dieter Saur, Roland Rad
Published in: Nature Protocols, Issue 17, 2023, Page(s) 1903-1925, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-022-00700-y

In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

Author(s): Anja Fischer, Robert Lersch, Niklas de Andrade Krätzig, Alexander Strong, Mathias J. Friedrich, Julia Weber, Thomas Engleitner, Rupert Öllinger, Hsi-Yu Yen, Ursula Kohlhofer, Irene Gonzalez-Menendez, David Sailer, Liz Kogan, Mari Lahnalampi, Saara Laukkanen, Thorsten Kaltenbacher, Christine Klement, Majdaddin Rezaei, Tim Ammon, Juan J. Montero, Günter Schneider, Julia Mayerle, Mathias Heikenwä
Published in: Cell Genomics, Issue 3, 2025, Page(s) 100276, ISSN 2666-979X
Publisher: Elsevier BV
DOI: 10.1016/j.xgen.2023.100276

Analysis pipelines for cancer genome sequencing in mice

Author(s): Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou, Mathias J. Friedrich, Dieter Saur, Ignacio Varela, Roland Rad
Published in: Nature Protocols, Issue 15/2, 2020, Page(s) 266-315, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0234-7

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

Author(s): Juan J. Montero, Riccardo Trozzo, Maya Sugden, Rupert Öllinger, Alexander Belka, Ekaterina Zhigalova, Paul Waetzig, Thomas Engleitner, Marc Schmidt-Supprian, Dieter Saur, Roland Rad
Published in: Nature Methods, Issue 21, 2024, Page(s) 584-596, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-024-02190-0

A disease model resource reveals core principles of tissue-specific cancer evolution

Author(s): Mueller S, de Andrade Krätzig N, Tschurtschentaler M, Silva MG, Thordsen C, Simon P, Saab F, Zukowska M, Trozzo R, Öllinger R, Griger J, Groß N, Kaltenbacher T, Groll T, Zaurito A, Bärthel S, Falcomatà S, Strong A, Najajreh M, Papargyriou A, Maresch R, Collins K, Sailer D, Schneeweis C, Burger C, Klement C, Reichert M, Moser M, Neumann J, Vassiliou G, Cadiñanos J, Varela I, Marr C, Chesler L
Published in: Nature, 2026, ISSN 0028-0836
Publisher: Nature Publishing Group

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Author(s): Markus Breunig, Jessica Merkle, Martin Wagner, Michael K. Melzer, Thomas F.E. Barth, Thomas Engleitner, Johannes Krumm, Sandra Wiedenmann, Christian M. Cohrs, Lukas Perkhofer, Gaurav Jain, Jana Krüger, Patrick C. Hermann, Maximilian Schmid, Tamara Madácsy, Árpád Varga, Joscha Griger, Ninel Azoitei, Martin Müller, Oliver Wessely, Pamela G. Robey, Sandra Heller, Zahra Dantes, Maximilian Reicher
Published in: Cell Stem Cell, Issue 28, 2025, Page(s) 1105-1124.e19, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.03.005

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Author(s): Chiara Falcomatà, Stefanie Bärthel, Günter Schneider, Roland Rad, Marc Schmidt-Supprian, Dieter Saur
Published in: Cancer Discovery, Issue 13, 2025, Page(s) 278-297, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-22-0876

CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver

Author(s): Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Chri
Published in: Nature Protocols, Issue 17, 2022, Page(s) 1142-1188, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00677-0