Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity

Project Information

MATRIX

Grant agreement ID: 819775

DOI 10.3030/819775

EC signature date 29 April 2019

Start date 1 September 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 375,00

EU contribution € 1 999 375,00

Coordinated by

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain

Publications

Peer reviewed articles (9)

Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences

Author(s): Gómez-Talavera S, Fernandez-Jimenez R, Fuster V, Nothnagel ND, Kouwenhoven M, Clemence M, García-Lunar I, Gómez-Rubín MC, Navarro F, Pérez-Asenjo B, Fernández-Friera L, Calero MJ, Orejas M, Cabrera JA, Desco M, Pizarro G, Ibáñez B, Sánchez-González J.
Published in: Journal of the American College of Cardiology (JACC), Issue 18767591, 2021, ISSN 1876-7591
Publisher: Elsevier
DOI: 10.1016/j.jcmg.2021.02.031

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Author(s): Heusch, Gerd; Andreadou, Ioanna; Bell, Robert; Bertero, Edoardo; Botker, Hans-Erik; Davidson, Sean M.; Downey, James; Eaton, Philip; Ferdinandy, Peter; Gersh, Bernard J.; Giacca, Mauro; Hausenloy, Derek J.; Ibanez, Borja; Krieg, Thomas; Maack, Christoph; Schulz, Rainer; Sellke, Frank; Shah, Ajay M.; Thiele, Holger; Yellon, Derek M.; Di Lisa, Fabio
Published in: REDOX BIOLOGY, Issue 2023 Nov:67:10289 // Fifty issues a year, 2023, Page(s) 1-46, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2023.102894

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Author(s): Nicolas-Avila, Jose A.; Lechuga-Vieco, Ana V.; Esteban-Martinez, Lorena; Sanchez-Diaz, Maria; Diaz-Garcia, Elena; Santiago, Demetrio J.; Rubio-Ponce, Andrea; Li, Jackson LiangYao; Balachander, Akhila; Quintana, Juan A.; Martinez-de-Mena, Raquel; Castejon-Vega, Beatriz; Pun-Garcia, Andres; Traves, Paqui G.; Bonzon-Kulichenko, Elena; Garcia-Marques, Fernando; Cusso, Lorena; A-Gonzalez, Noelia; Gonza
Published in: CELL, Issue 2020 Oct 1;183(1) // Biweekly, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.031

Cardiac Mitochondrial Transplantation: The Force Awakens.

Author(s): Ibáñez, Borja; Villena-Gutierrez, Rocio
Published in: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Issue 5, 2021, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2021.01.017

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity

Author(s): Carlos Galán-Arriola, Rocio Villena-Gutiérrez, María I Higuero-Verdejo, Iván A Díaz-Rengifo, Gonzalo Pizarro, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Rodrigo D García, David González-Calle, Manuel Lobo, Pedro L Sánchez, Eduardo Oliver, Raúl Córdoba, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
Published in: Cardiovascular Research, Issue 117/4, 2020, Page(s) 1132-1143, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaa181

Coronary microcirculation damage in anthracycline cardiotoxicity

Author(s): Carlos Galán-Arriola, Jean Paul Vílchez-Tschischke, Manuel Lobo, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Rocio Villena-Gutiérrez, Álvaro Macías, Iván A Díaz-Rengifo, Eduardo Oliver, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab053

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Author(s): Desdin-Mico, Gabriela; Soto-Heredero, Gonzalo; Francisco Aranda, Juan; Oller, Jorge; Carrasco, Elisa; Gabande-Rodriguez, Enrique; Maria Blanco, Eva; Alfranca, Arantzazu; Cusso, Lorena; Desco, Manuel; Ibanez, Borja; Gortazar, Arancha R.; Fernandez-Marcos, Pablo; Navarro, Maria N.; Hernaez, Bruno; Alcami, Antonio; Baixauli, Francesc; Mittelbrunn, Maria
Published in: SCIENCE, Issue 2020 Jun 19;368(6497) // Weekly, 2020, Page(s) 1371-1376, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax0860

The Quest for an Early Marker of Anthracycline-Induced Cardiotoxicity

Author(s): Ibáñez, Borja; Moreno-Arciniegas, Andrea
Published in: JACC: Basic to Translational Science, Issue 9, 2022, ISSN 2452-302X
Publisher: ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2021.11.010

Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics

Author(s): Andrés Pun-García; Agustín Clemente-Moragón; Rocio Villena-Gutierrez; Monica Gómez; David Sanz-Rosa; Anabel Díaz-Guerra; Belén Prados; Juan Pablo Medina; Fermí Montó; Maria Dolores Ivorra; Cristina Márquez-López; Alessandro Cannavo; Juan A. Bernal; Walter J. Koch; Valentin Fuster; José Luis de la Pompa; Eduardo Oliver; Borja Ibanez
Published in: Pun García, Andrés Clemente Moragón, Agustín Villena Gutierrez, Rocio Gómez, Mónica Sanz Rosa, David Díaz Guerra, Anabel Prados, Belén Medina, Juan Pablo Montó Guillot, Fermí Josep Ivorra Insa, María Dolores Márquez-López, Cristina Cannavo, Alessandro Bernal, Juan A. Koch, Walter J. Fuster, Valentin De la Pompa, Jose Luis Oliver Pérez, Eduardo Ibanez, Borja 2022 Beta-3 adrenergic rec, Issue 1, 2022, ISSN 0300-8428
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00966-z

Other (1)

Remote Ischemic Conditioning for Anthracycline Cardiotoxicity The Need to Protect the Most Vulnerable

Author(s): Ibanez, Borja; Gomes-Silva, Maria
Published in: JACC: CARDIOONCOLOGY, Issue 2023 Jun 20;5(3) // Six issues a year, 2023, Page(s) 356-359, ISSN 2666-0873
Publisher: ELSEVIER
DOI: 10.1016/j.jaccao.2023.05.002