Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity

Project Information

MATRIX

Grant agreement ID: 819775

DOI

10.3030/819775

Project closed

EC signature date 29 April 2019

Start date 1 September 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 375,00

EU contribution

€ 1 999 375,00

Coordinated by

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Unidirectional association of clonal hematopoiesis with atherosclerosis development

Author(s): Miriam Díez-Díez, Beatriz L. Ramos-Neble, Jorge de la Barrera, J. C. Silla-Castro, Ana Quintas, Enrique Vázquez, M. Ascensión Rey-Martín, Benedetta Izzi, Lucía Sánchez-García, Inés García-Lunar, Guiomar Mendieta, Virginia Mass, Nuria Gómez-López, Cristina Espadas, Gema González, Antonio J. Quesada, Ana García-Álvarez, Antonio Fernández-Ortiz, Enrique Lara-Pezzi, Ana Dopazo, Fátima
Published in: Nature Medicine, Issue 30, 2024, Page(s) 2857-2866, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03213-1

Bone marrow activation in response to metabolic syndrome and early atherosclerosis

Author(s): Ana Devesa, Manuel Lobo-González, Juan Martínez-Milla, Belén Oliva, Inés García-Lunar, Annalaura Mastrangelo, Samuel España, Javier Sanz, José M Mendiguren, Hector Bueno, Jose J Fuster, Vicente Andrés, Antonio Fernández-Ortiz, David Sancho, Leticia Fernández-Friera, Javier Sanchez-Gonzalez, Xavier Rossello, Borja Ibanez, Valentin Fuster
Published in: European Heart Journal, Issue 43, 2022, Page(s) 1809-1828, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac102

Anthracycline Cardiotoxicity Induces Progressive Changes in Myocardial Metabolism and Mitochondrial Quality Control

Author(s): Anabel Díaz-Guerra, Rocío Villena-Gutiérrez, Agustín Clemente-Moragón, Mónica Gómez, Eduardo Oliver, Miguel Fernández-Tocino, Carlos Galán-Arriola, Laura Cádiz, Borja Ibáñez
Published in: JACC: CardioOncology, Issue 6, 2024, Page(s) 217-232, ISSN 2666-0873
Publisher: Elsevier BV
DOI: 10.1016/j.jaccao.2024.02.005

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Author(s): Heusch, Gerd; Andreadou, Ioanna; Bell, Robert; Bertero, Edoardo; Botker, Hans-Erik; Davidson, Sean M.; Downey, James; Eaton, Philip; Ferdinandy, Peter; Gersh, Bernard J.; Giacca, Mauro; Hausenloy, Derek J.; Ibanez, Borja; Krieg, Thomas; Maack, Christoph; Schulz, Rainer; Sellke, Frank; Shah, Ajay M.; Thiele, Holger; Yellon, Derek M.; Di Lisa, Fabio
Published in: REDOX BIOLOGY, Issue 2023 Nov:67:10289 // Fifty issues a year, 2023, Page(s) 1-46, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2023.102894

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp>, the <scp>ESC</scp> Council of Cardio‐Oncology, and the <scp>ESC</scp> Working Group on Cellular Biology of the Heart

Author(s): Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giusepp
Published in: European Journal of Heart Failure, Issue 27, 2025, Page(s) 1028-1046, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.3636

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Author(s): Nicolas-Avila, Jose A.; Lechuga-Vieco, Ana V.; Esteban-Martinez, Lorena; Sanchez-Diaz, Maria; Diaz-Garcia, Elena; Santiago, Demetrio J.; Rubio-Ponce, Andrea; Li, Jackson LiangYao; Balachander, Akhila; Quintana, Juan A.; Martinez-de-Mena, Raquel; Castejon-Vega, Beatriz; Pun-Garcia, Andres; Traves, Paqui G.; Bonzon-Kulichenko, Elena; Garcia-Marques, Fernando; Cusso, Lorena; A-Gonzalez, Noelia; Gonza
Published in: CELL, Issue 2020 Oct 1;183(1) // Biweekly, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.031

Cardiac Mitochondrial Transplantation: The Force Awakens.

Author(s): Ibáñez, Borja; Villena-Gutierrez, Rocio
Published in: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Issue 5, 2021, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2021.01.017

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity

Author(s): Carlos Galán-Arriola, Rocio Villena-Gutiérrez, María I Higuero-Verdejo, Iván A Díaz-Rengifo, Gonzalo Pizarro, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Rodrigo D García, David González-Calle, Manuel Lobo, Pedro L Sánchez, Eduardo Oliver, Raúl Córdoba, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
Published in: Cardiovascular Research, Issue 117/4, 2020, Page(s) 1132-1143, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaa181

Coronary microcirculation damage in anthracycline cardiotoxicity

Author(s): Carlos Galán-Arriola, Jean Paul Vílchez-Tschischke, Manuel Lobo, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Rocio Villena-Gutiérrez, Álvaro Macías, Iván A Díaz-Rengifo, Eduardo Oliver, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab053

SGLT2i Therapy Prevents Anthracycline-Induced Cardiotoxicity in a Large Animal Model by Preserving Myocardial Energetics

Author(s): Danielle Medina-Hernández, Laura Cádiz, Annalaura Mastrangelo, Andrea Moreno-Arciniegas, Miguel Fernández Tocino, Alejandro A. Cueto Becerra, Anabel Díaz-Guerra Priego, Warren A. Skoza, María Isabel Higuero-Verdejo, Gonzalo Javier López-Martín, Claudia Pérez-Martínez, Antonio de Molina-Iracheta, María Caballero-Valderrama, Javier Sánchez-González, David Sancho, Valentin Fuster, Carlos
Published in: JACC: CardioOncology, Issue 7, 2025, Page(s) 171-184, ISSN 2666-0873
Publisher: Elsevier BV
DOI: 10.1016/j.jaccao.2024.12.004

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Author(s): Desdin-Mico, Gabriela; Soto-Heredero, Gonzalo; Francisco Aranda, Juan; Oller, Jorge; Carrasco, Elisa; Gabande-Rodriguez, Enrique; Maria Blanco, Eva; Alfranca, Arantzazu; Cusso, Lorena; Desco, Manuel; Ibanez, Borja; Gortazar, Arancha R.; Fernandez-Marcos, Pablo; Navarro, Maria N.; Hernaez, Bruno; Alcami, Antonio; Baixauli, Francesc; Mittelbrunn, Maria
Published in: SCIENCE, Issue 2020 Jun 19;368(6497) // Weekly, 2020, Page(s) 1371-1376, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax0860

A Novel Circulating Noncoding Small RNA for the Detection of Acute Myocarditis

Author(s): Rafael Blanco-Domínguez, Raquel Sánchez-Díaz, Hortensia de la Fuente, Luis J. Jiménez-Borreguero, Adela Matesanz-Marín, Marta Relaño, Rosa Jiménez-Alejandre, Beatriz Linillos-Pradillo, Katerina Tsilingiri, María L. Martín-Mariscal, Laura Alonso-Herranz, Guillermo Moreno, Roberto Martín-Asenjo, Marcos M. García-Guimaraes, Katelyn A. Bruno, Esteban Dauden, Isidoro González-Álvaro, Luisa
Published in: New England Journal of Medicine, Issue 384, 2025, Page(s) 2014-2027, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2003608

Priorities in Cardio-Oncology Basic and Translational Science

Author(s): Fadi N. Salloum, Carlo G. Tocchetti, Pietro Ameri, Hossein Ardehali, Aarti Asnani, Rudolf A. de Boer, Paul Burridge, José-Ángel Cabrera, Javier de Castro, Raúl Córdoba, Ambra Costa, Susan Dent, Daniel Engelbertsen, María Fernández-Velasco, Mike Fradley, José J. Fuster, Carlos Galán-Arriola, Inés García-Lunar, Alessandra Ghigo, Anna González-Neira, Emilio Hirsch, Borja Ibáñez, Richard
Published in: JACC: CardioOncology, Issue 5, 2023, Page(s) 715-731, ISSN 2666-0873
Publisher: Elsevier BV
DOI: 10.1016/j.jaccao.2023.08.003

The Quest for an Early Marker of Anthracycline-Induced Cardiotoxicity

Author(s): Ibáñez, Borja; Moreno-Arciniegas, Andrea
Published in: JACC: Basic to Translational Science, Issue 9, 2022, ISSN 2452-302X
Publisher: ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2021.11.010

Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics

Author(s): Andrés Pun-García; Agustín Clemente-Moragón; Rocio Villena-Gutierrez; Monica Gómez; David Sanz-Rosa; Anabel Díaz-Guerra; Belén Prados; Juan Pablo Medina; Fermí Montó; Maria Dolores Ivorra; Cristina Márquez-López; Alessandro Cannavo; Juan A. Bernal; Walter J. Koch; Valentin Fuster; José Luis de la Pompa; Eduardo Oliver; Borja Ibanez
Published in: Pun García, Andrés Clemente Moragón, Agustín Villena Gutierrez, Rocio Gómez, Mónica Sanz Rosa, David Díaz Guerra, Anabel Prados, Belén Medina, Juan Pablo Montó Guillot, Fermí Josep Ivorra Insa, María Dolores Márquez-López, Cristina Cannavo, Alessandro Bernal, Juan A. Koch, Walter J. Fuster, Valentin De la Pompa, Jose Luis Oliver Pérez, Eduardo Ibanez, Borja 2022 Beta-3 adrenergic rec, Issue 1, 2022, ISSN 0300-8428
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00966-z

Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences

Author(s): Sandra Gómez-Talavera, Rodrigo Fernandez-Jimenez, Valentín Fuster, Nils D. Nothnagel, Marc Kouwenhoven, Matthew Clemence, Inés García-Lunar, María C. Gómez-Rubín, Felipe Navarro, Braulio Pérez-Asenjo, Leticia Fernández-Friera, María J. Calero, Miguel Orejas, José A. Cabrera, Manuel Desco, Gonzalo Pizarro, Borja Ibáñez, Javier Sánchez-González
Published in: JACC: Cardiovascular Imaging, Issue 14, 2021, Page(s) 1742-1754, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2021.02.031

Cardioprotection strategies for anthracycline cardiotoxicity

Author(s): Andrea Moreno-Arciniegas, Laura Cádiz, Carlos Galán-Arriola, Agustín Clemente-Moragón, Borja Ibáñez
Published in: Basic Research in Cardiology, Issue 120, 2025, Page(s) 71-90, ISSN 1435-1803
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00395-024-01078-6

β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury

Author(s): Miguel Fernández-Tocino, Andrés Pun-Garcia, Mónica Gómez, Agustín Clemente-Moragón, Eduardo Oliver, Rocío Villena-Gutierrez, Sofía Trigo-Anca, Anabel Díaz-Guerra, David Sanz-Rosa, Belén Prados, Lara del Campo, Vicente Andrés, Valentín Fuster, José Luis de la Pompa, Laura Cádiz, Borja Ibañez
Published in: Basic Research in Cardiology, Issue 119, 2024, Page(s) 773-794, ISSN 1435-1803
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00395-024-01072-y

Other (1)

Remote Ischemic Conditioning for Anthracycline Cardiotoxicity The Need to Protect the Most Vulnerable

Author(s): Ibanez, Borja; Gomes-Silva, Maria
Published in: JACC: CARDIOONCOLOGY, Issue 2023 Jun 20;5(3) // Six issues a year, 2023, Page(s) 356-359, ISSN 2666-0873
Publisher: ELSEVIER
DOI: 10.1016/j.jaccao.2023.05.002