Supramolecular engineering of glycan-decorated peptides as synthetic vaccines

Project Information

SUPRAVACC

Grant agreement ID: 819856

DOI

10.3030/819856

Project closed

EC signature date 20 March 2019

Start date 1 April 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response

Author(s): Adele Gabba; Riem Attariya; Sandra Behren; Christian Pett; Joost C. van der Horst; Hajime Yurugi; Jin Yu; Moritz Urschbach; Juan Sabin; Gabriel Birrane; Edgar Schmitt; Sandra J. van Vliet; Pol Besenius; Ulrika Westerlind; Paul V. Murphy
Published in: J. Am. Chem. Soc., 2023, Page(s) 13027-13037, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c12843

Aliphatic polycarbonates with acid degradable ketal side groups as multi-pH-responsive immunodrug nanocarriers

Author(s): Adrian V. Hauck, Patric Komforth, Jessica Erlenbusch, Judith Stickdorn, Krzysztof Radacki, Holger Braunschweig, Pol Besenius, Simon Van Herck, Lutz Nuhn
Published in: Biomaterials Science, Issue 13, 2025, Page(s) 1414-1425, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4bm00949e

Modular Platform of Carbohydrates-modified Supramolecular Polymers Based on Dendritic Peptide Scaffolds

Author(s): Long Li; Libin Wu; Moritz Urschbach; David Straßburger; Xiaomei Liu; Pol Besenius; Guosong Chen
Published in: ACS Polym. Au, 2022, Page(s) 478-485, ISSN 2694-2453
Publisher: ACS
DOI: 10.1021/acspolymersau.2c00032

Cucurbit[8]uril Mediated Supramolecular and Photocrosslinked Interpenetrating Network Hydrogel Matrices for 3D‐Bioprinting

Author(s): Yuqing Wang, Alexander Matthias Bimmermann, Meik Neufurth, Pol Besenius
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202313270

Photocaged and Water‐Soluble Glucose Functionalization for Spatiotemporal Acidification Pathways

Author(s): Nikolai Hempel, Michelle Szostak, Pol Besenius
Published in: Helvetica Chimica Acta, Issue 109, 2026, ISSN 0018-019X
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202500211

Supramolecular Assembly and Thermogelation Strategies Using Peptide–Polymer Conjugates

Author(s): Chloé Pascouau, Maren Schweitzer, Pol Besenius
Published in: Biomacromolecules, Issue 25, 2025, Page(s) 2659-2678, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c00031

Impact of sample history and solvent effects on pathway control in the supramolecular polymerisation of Au(<scp>i</scp>)-metallopeptide amphiphiles

Author(s): Marius Thomas; Vanessa Lewe; Jonas Kölsch; Moritz Urschbach; Jessica Erlenbusch; Oliver Sven Stach; Pol Besenius
Published in: Polym. Chem., 2023, Page(s) 1888-1892, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3py00053b

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups

Author(s): Adrian V. Hauck, Michael Fichter, Laura J. Rosenberger, Jannis Willig, Alexander Fuchs, Felicia Schön, Paul Schneider, Carolina Medina‐Montano, Taufiq Ahmad, Jessica Erlenbusch, Pol Besenius, Leonard Kaps, Matthias Bros, Stephan Grabbe, Volker Mailänder, Jürgen Groll, Lutz Nuhn
Published in: Advanced Materials, Issue 38, 2026, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202511752

1,4-Oxazepan-7-one trifluoroacetate: a modular monomer precursor for the synthesis of functional and biodegradable poly(amino esters)

Author(s): Tino Mackiol, Chloé Pascouau, Manuel Nagel, Tamara M. Bizmark, Luca Montesel, Jochen Fischer-Schuch, Pol Besenius
Published in: Polymer Chemistry, Issue 16, 2026, Page(s) 3450-3458, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5py00522a

Metal Ion-Specific Modulation of Network Connectivity and Defects in Poly(ethylene glycol)–Peptide Conjugate Assemblies and Hydrogels

Author(s): Mostafa Ahmadi, Kamila Wittek, Hanna Sophie Rieger, Marius Thomas, Lars Hartmann, Pol Besenius, Sebastian Seiffert
Published in: Chemistry of Materials, Issue 38, 2026, Page(s) 1240-1252, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.5c02542

Regulating H₂S release from self-assembled peptide H₂S-donor conjugates using cysteine derivatives

Author(s): Zhao Li, Marius Thomas, Christian M. Berač, Oliver S. Stach, Pol Besenius, John B. Matson
Published in: Organic &amp; Biomolecular Chemistry, Issue 22, 2024, Page(s) 8173-8181, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4ob01148a

The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response

Author(s): Natascha Stergiou; Moritz Urschbach; Adele Gabba; Edgar Schmitt; Horst Kunz; Pol Besenius
Published in: The Chemical Record, 2021, Page(s) 3313-3331, ISSN 1527-8999
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/tcr.202100182

The Impact of Single Amino Acid Insertion on the Supramolecular Assembly Pathway of Aromatic Peptide Amphiphiles

Author(s): Ayato Higuchi, Arka Som, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Pol Besenius
Published in: Chemistry – A European Journal, Issue 31, 2025, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202404233

Synthesis, Supramolecular Assembly, and Hydrogelation of Poly(amino ester) ABA Triblock Copolymers

Author(s): Chloé Pascouau, Kamila Wittek, Jessica Erlenbusch, Sebastian Becker, Jochen Fischer-Schuch, Pablo G. Argudo, Pol Besenius
Published in: Biomacromolecules, Issue 27, 2026, Page(s) 567-579, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.5c01828

Other (1)

Non-equilibrium Spatiotemporal Patterns of Charge-transfer Supramolecular Assembly

Author(s): Surbhi Sharma, Mohit Kumar, Jessica Erlenbusch, Ankit Sakhuja, Subi J. George, Shikha Dhiman
Published in: 2024
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2024-r3l1b