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Deciphering and predicting the evolution of cancer cell populations

Project description

Novel sequencing technology for cancer evolution analysis

It is well established that tumours undergo evolution and generate different genetic clones during their lifetime. The EU-funded CANCEREVO project is interested to understand the dynamics of these changes and their clinical ramifications. For this purpose, scientists will investigate circulating tumour DNA (ctDNA) from metastatic gastro-oesophageal carcinomas using a novel technology for deep exome sequencing. This technology offers the necessary sensitivity to detect rare cancer subclones and track the evolution of the entire population of cancer cells. Importantly, it can be used in the clinic and to predict drug resistance mechanisms to chemotherapy and immunotherapy.

Host institution

QUEEN MARY UNIVERSITY OF LONDON
Net EU contribution
€ 1 250 303,75
Address
327 Mile End Road
E1 4NS London
United Kingdom

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 1 250 303,75
Address
327 Mile End Road
E1 4NS London

See on map

Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Net EU contribution
€ 749 696,25
Address
Old Brompton Road 123
SW7 3RP London

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00