Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools

Project Information

CRISPR2.0

Grant agreement ID: 820152

DOI 10.3030/820152

EC signature date 7 March 2019

Start date 1 May 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 525,00

EU contribution € 1 996 525,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (4)

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

Author(s): Kristina Makasheva; Louise C. Bryan; Carolin Anders; Sherin Panikulam; Martin Jinek; Beat Fierz
Published in: Journal of the American Chemical Society, Issue 143, 2021, Page(s) 16313–16319, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.5167/uzh-210326

Structural basis for the assembly of the type V CRISPR-associated transposon complex

Author(s): Michael Schmitz, Irma Querques, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: Cell, Issue 185, 2022, Page(s) 4999-5010, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.11.009

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Author(s): Carmela Garcia-Doval, Frank Schwede, Christian Berk, Jakob T. Rostøl, Ole Niewoehner, Oliver Tejero, Jonathan Hall, Luciano A. Marraffini, Martin Jinek
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15334-5

Target site selection and remodelling by type V CRISPR-transposon systems

Author(s): Irma Querques, Michael Schmitz, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: Nature, Issue 599, 2021, Page(s) 497-502, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04030-z

Other (1)

Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons

Author(s): Michael Schmitz, Irma Querques, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.06.17.496590