Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools

Project Information

CRISPR2.0

Grant agreement ID: 820152

DOI 10.3030/820152

EC signature date 7 March 2019

Start date 1 May 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 525,00

EU contribution € 1 996 525,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA

Author(s): Giada Finocchio; Balwina Koopal; Ana Potocnik; Clint Heijstek; Adrie H Westphal; Martin Jinek; Daan C Swarts
Published in: Nucleic Acids Research, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad1248

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

Author(s): Kristina Makasheva; Louise C. Bryan; Carolin Anders; Sherin Panikulam; Martin Jinek; Beat Fierz
Published in: Journal of the American Chemical Society, Issue 143, 2021, Page(s) 16313–16319, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.5167/uzh-210326

Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2

Author(s): Kenny Jungfer, Annina Sigg, Martin Jinek
Published in: Nucleic Acids Research, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad1102

Structural basis for the assembly of the type V CRISPR-associated transposon complex

Author(s): Michael Schmitz, Irma Querques, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: Cell, Issue 185, 2022, Page(s) 4999-5010, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.11.009

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Author(s): Carmela Garcia-Doval, Frank Schwede, Christian Berk, Jakob T. Rostøl, Ole Niewoehner, Oliver Tejero, Jonathan Hall, Luciano A. Marraffini, Martin Jinek
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15334-5

Target site selection and remodelling by type V CRISPR-transposon systems

Author(s): Irma Querques, Michael Schmitz, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: Nature, Issue 599, 2021, Page(s) 497-502, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04030-z

Other (1)

Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons

Author(s): Michael Schmitz, Irma Querques, Seraina Oberli, Christelle Chanez, Martin Jinek
Published in: 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.06.17.496590