Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools

Project description

Molecular insight into microbial defence tools

From restriction endonucleases to CRISPR-Cas nuclease-based editing systems, prokaryotes have evolved a battery of immune responses to fight parasites. At the same time, these defence systems have served as valuable genetic engineering and genome editing tools in the hands of scientists. Recent years have witnessed the pros and cons of the CRISPR gene editing technology, underscoring the need for further development. In light of this, the EU-funded CRISPR2.0 project will investigate the molecular architectures and mechanisms of alternative CRISPR-based systems. The ultimate goal is to understand the evolution of genome defence mechanisms and generate novel gene editing tools.

Fields of science

Host institution

UNIVERSITAT ZURICH

Net EU contribution

€ 1 996 525,00

Address

Ramistrasse 71
8006 Zurich
Switzerland

Region

Schweiz/Suisse/Svizzera Zürich Zürich

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)