Project description
Molecular insight into microbial defence tools
From restriction endonucleases to CRISPR-Cas nuclease-based editing systems, prokaryotes have evolved a battery of immune responses to fight parasites. At the same time, these defence systems have served as valuable genetic engineering and genome editing tools in the hands of scientists. Recent years have witnessed the pros and cons of the CRISPR gene editing technology, underscoring the need for further development. In light of this, the EU-funded CRISPR2.0 project will investigate the molecular architectures and mechanisms of alternative CRISPR-based systems. The ultimate goal is to understand the evolution of genome defence mechanisms and generate novel gene editing tools.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesgeneticsDNA
- natural sciencesbiological sciencesgeneticsgenomesprokaryotic genomes
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
8006 Zurich
Switzerland
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Beneficiaries (1)
8006 Zurich
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