The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use

Livrables

Review of health-economic approaches and design of a generic modelling framework

Review of health-economic approaches for diagnostic-driven antibiotic use and design of a generic modelling framework to be applied in this project (continuously updated between months 12 to 48)

Database business plan
Recommendations for an innovative fit for purpose pricing and funding models for CA-ARTI-Dx

Recommendations for an innovative fit for purpose pricing and funding models for CAARTIDx

Review of pricing and reimbursement policies for CA-ARTI-Dx

Review of pricing and reimbursement policies for CA-ARTI-Dx in at least 15 European countries in country briefs

Clinical Algorithm for the diagnosis of CA-ARTI
Transferring results to the broader spectrum of EU Member States and H2020-associated countries.

Report on transferring results to the broader spectrum of EU Member States and H2020-associated countries.

User Requirement Specification Document for diagnostics of CA-ARTI;

User Requirement Specification Document for diagnostics of CA-ARTI

Policy recommendations, consensus report and a white paper;
key facilitators and barriers to adoption of CA-ARTI-Dx and policy and practice recommendations

Description of key facilitators and barriers to adoption of CAARTIDx and policy and practice recommendations for European community care setting

VALUE-Dx Business Plan and sustainability model, including implementation plan

VALUEDx Business Plan and sustainability model including implementation plan

Technological Roadmap for diagnostics of CA-ARTI
Health-economic model applied to CA-ARTI-Dx

Health-economic model applied to CA-ARTI-Dx, including base-case, sensitivity and scenario analysis on diagnostic strategies and their impact on AMR using the innovative health-economic model

Biobank business plan

VALUE-Dx Course

VALUE Dx Course, updated in motnhs 12 and 48

Media Toolkit
e-Portal App

E-Portal App

E-Portal

Publications

Stakeholders’ views and experiences on implementing new diagnostics in primary care to support management of community-acquired acute respiratory tract infections: a qualitative study

Auteurs: Melanie Eugenie Hoste, Elien Colman, Marta Wanat, Gail Hayward, Jean-Louis Tissier, Maarten Postma, Herman Goossens, Sibyl Anthierens, Sarah Tonkin-Crine
Publié dans: Frontiers in Public Health, 2023
Éditeur: Frontiers
DOI: 10.3389/fpubh.2023.1216940

Point prevalence audit surveys of respiratory tract infection consultations and antibiotic prescribing in primary care before and during the COVID-19 pandemic in Ireland

Auteurs: M Shah; A Fleming; T M Barbosa; A W van der Velden; S Parveen; A Vellinga
Publié dans: Journal of Antimicrobial Chemotherapy, Numéro 17, 2023, Page(s) 1270–1277
Éditeur: Oxford Academic
DOI: 10.1093/jac/dkad088

Expert Guidance on Target Product Profile Development for AMR Diagnostic Tests

Auteurs: Bachmann, T. T., Mitsakakis, K., Hays, J. P., van Belkum, A., Russom, A., Luedke, G., Simonsen, G. S., Abel, G., Peter, H., Goossens, H., Moran-Gilad, J., Vila, J., Becker, K., Moons, P., Sampath, R., Peeling, R., Luz, S., Van Staa, T. & Di Gregori, V.
Publié dans: BMJ Global Health, 2023, Page(s) 1-7
Éditeur: BMJ
DOI: 10.1136/bmjgh-2023-012319

Towards Autonomous Living Meta-Analyses: A Framework for Automation of Systematic Review and Meta-Analysis

Auteurs: Anna Górska, Evelina Tacconelli
Publié dans: Studies in health technology and informatics, 2024, Page(s) 378-382
Éditeur: IOS Press
DOI: 10.3233/shti240427

Antibiotics and uncertainty of diagnosis in viral respiratory infections: Point-prevalence survey across 15 European countries

Auteurs: PPAS4 Paediatric Group: Leila Khosravi, Dominic Imort, Manuel Gijon Mediavilla, Leila Ahmed, Emanuela Früh, Hanna Renk, Maggie Nyirenda Nyang'wa, Ratha Sritharan, Emily Bongard, Rune Aabenhus, Anca Balan, Femke Böhmer, Slawomir Chlabicz, Samuel Coenen, Ana García-Sangenís, Hrachuhi Ghazaryan, Christos Lionis, Sanne van der Linde, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Akke Vellinga,
Publié dans: Acta Paediatrica, 2023
Éditeur: Wiley Online Library
DOI: 10.1111/apa.16855

Improving antibiotic prescribing - Recommendations for funding and pricing to enhance use of point-of-care tests

Auteurs: Sabine Vogler, Caroline Steigenberger, Friederike Windisch
Publié dans: Health Policy Open, 2024
Éditeur: Elsevier
DOI: 10.1016/j.hpopen.2024.100129

Assessing, Pricing and Funding Point-of-Care Diagnostic Tests for Community-Acquired Acute Respiratory Tract Infections–Overview of Policies Applied in 17 European Countries

Auteurs: Sabine Vogler; Friederike Windisch
Publié dans: Antibiotics; Volume 11; Numéro 8; Pages: 987, Numéro 14, 2022
Éditeur: MDPI
DOI: 10.3390/antibiotics11080987

Point-of-care testing, antibiotic prescribing, and prescribing confidence for respiratory tract infections in primary care: a prospective audit in 18 European countries

Auteurs: Alike W. van der Velden, Alma C. van de Pol, Emily Bongard, Daniela Cianci, Rune Aabenhus, Anca Balan, Femke Böhmer, Valerija Bralic Lang, Pascale Bruno, Slawomir Chlabicz, Samuel Coenen, Annelies Colliers, Anna Garcia-Sangenis, Hrachuhi Ghazaryan, Mciek Godycki-Cwirko , Siri Jensen, Christos Lionis, Sanne van der Linde, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Akke Vellinga, Ihor Zastavn
Publié dans: BGJP Open, 2021
Éditeur: Royal College of General Practitioners
DOI: 10.3399/bjgpo.2021.0212

Using point-of-care diagnostic testing for improved antibiotic prescription: an economic model

Auteurs: Antoñanzas F, Juárez C, Rodríguez R
Publié dans: Health Economics Review, 2021
Éditeur: Nature Springer
DOI: 10.1186/s13561-021-00326-y

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Auteurs: Rojas García P, van der Pol S, van Asselt ADI, et al.
Publié dans: Antibiotics, 2022
Éditeur: MDPI
DOI: 10.3390/antibiotics11010027

The Opportunity of Point-of-Care Diagnostics in General Practice: Modelling the Effects on Antimicrobial Resistance

Auteurs: van der Pol, S., Jansen, D. E., van der Velden, A. W., Butler, C. C., Verheij, T. J., Friedrich, A. W., van Asselt, A. D.
Publié dans: Pharmacoeconomics, 2022
Éditeur: Springer
DOI: 10.1007/s40273-022-01165-3

European wide benchmarking of disease-specific quality indicators for outpatient antibiotic prescribing for respiratory infections: ESAC quality indicators applied to point prevalence audit surveys in 13 European countries

Auteurs: Akke Vellinga, Addiena Luke-Currier, Nathaly Garzón-Orjuela, Rune Aabenhus, Marilena Anastasaki, Anca Balan, Femke Böhmer, Valerija Bralić Lang, Slawomir Chlabicz, Samuel Coenen, Ana García-Sangenís, Anna Kowalczyk, Lile Malania, Angela Tomacinschii, Sanne R. van der Linde, Emily Bongard, Christopher C. Butler, Herman Goossens, Alike W. van der Velden
Publié dans: Antibiotics, 2023
Éditeur: Nature Publishing Group
DOI: 10.3390/antibiotics12030572

Systematic review and meta-analysis of diagnostics accuracy in community-acquired acute respiratory tract infections (protocol)

Auteurs: Pasquale De Nardo, Elisa Gentilotti, Eleonora Cremonini, Fulvia Mazzaferri, Anna Gorska, Evelina Tacconelli, Mical Paul, Muna Mustafa, Till Bachmann, Christopher Butler, Samuel Coenen, Gail Hayward, Jorge Villacian, Herman Goossens, Itamar Poran
Publié dans: PROSPERO - International Prospective Register of Systematic Reviews, 2019
Éditeur: National Institute for Health Research - University of York

Usability of OMOP Common Data Model for Detailed Lab Microbiology Results

Auteurs: E. Theron, JF Gorse, X. Gansel
Publié dans: Studies in Health Technology and Informatics, 2022
Éditeur: IOS Press
DOI: 10.3233/shti220461

Barriers and Facilitators in Pricing and Funding Policies of European Countries That Impact the Use of Point-of-Care Diagnostics for Acute Respiratory Tract Infections in Outpatient Practices

Auteurs: Caroline Steigenberger; Friederike Windisch; Sabine Vogler
Publié dans: Diagnostics, Vol 13, Iss 23, p 3596 (2023), Numéro 15, 2023
Éditeur: MDPI
DOI: 10.3390/diagnostics13233596

Does diagnostic testing always decrease antibiotics prescriptions?

Auteurs: F. Antoñanzas, C. A. Juárez‑Castelló, R. Rodríguez‑Ibeas
Publié dans: The European Journal of Health Economics, 2022
Éditeur: Springer Nature
DOI: 10.1007/s10198-022-01488-0

Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections. A systematic review and meta-analysis

Auteurs: Gentilotti, E. et al
Publié dans: Clinical Microbiology and Infection, 2021
Éditeur: ESCMID
DOI: 10.1016/j.cmi.2021.09.025

Randomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections—trial protocol for the ADEQUATE Paediatric trial

Auteurs: ADEQUATE Paediatric Trial Group
Publié dans: BMJ Open, 2024
Éditeur: BMJ
DOI: 10.1136/bmjopen-2023-076338

Primary care for patients with respiratory tract infection before and early on in the COVID-19 pandemic: an observational study in 16 European countries

Auteurs: Alike W van der Velden, Eva A Bax, Emily Bongard, Rune Munck Aabenhus, Marilena Anastasaki, Sibyl Anthierens, Anca Balan, Femke Böhmer, Pascale Bruno, Slawomir Chlabicz, Samuel Coenen, Annelies Colliers, Susanne Emmerich, Ana Garcia-Sangenis, Hrachuhi Ghazaryan, Sanne R van der Linde, Lile Malania, József Pauer, Angela Tomacinschii, Sarah Tonkin-Crine, Akke Vellinga, Ihor Zastavnyy, Theo Verheij
Publié dans: BMJ Open, Numéro 11/7, 2021, Page(s) e049257, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-049257

Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting

Auteurs: Simon van der Pol, Paula Rojas Garcia, Fernando Antoñanzas Villar, Maarten J. Postma, Antoinette D. I. van Asselt
Publié dans: PharmacoEconomics, 2021, ISSN 1170-7690
Éditeur: Adis International Ltd.
DOI: 10.1007/s40273-021-01104-8

Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review

Auteurs: Paula Rojas García, Simon van der Pol, Antoinette D. I. van Asselt, Maarten Postma, Roberto Rodríguez-Ibeas, Carmelo A. Juárez-Castelló, Marino González, Fernando Antoñanzas
Publié dans: Antibiotics, Numéro 10/1, 2021, Page(s) 55, ISSN 2079-6382
Éditeur: MDPI
DOI: 10.3390/antibiotics10010055

Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review

Auteurs: Simon van der Pol, Paula Rojas Garcia, Maarten J. Postma, Fernando Antoñanzas Villar, Antoinette D. I. van Asselt
Publié dans: PharmacoEconomics, Numéro online, 2021, Page(s) online, ISSN 1170-7690
Éditeur: Adis International Ltd.
DOI: 10.1007/s40273-021-01054-1

Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis

Auteurs: Mona Mustafa Hellou, Anna Górska, Fulvia Mazzaferri, Eleonora Cremonini, Elisa Gentilotti, Pasquale De Nardo, Itamar Poran, Mariska M. Leeflang, Evelina Tacconelli, Mical Paul
Publié dans: Clinical Microbiology and Infection, Numéro 27/3, 2021, Page(s) 341-351, ISSN 1198-743X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2020.11.002

Multi-Criteria Decision Analysis to prioritize hospital admission of patients affected by COVID-19 in low-resource settings with hospital-bed shortage

Auteurs: Pasquale De Nardo, Elisa Gentilotti, Fulvia Mazzaferri, Eleonora Cremonini, Paul Hansen, Herman Goossens, Evelina Tacconelli, E. Durante Mangoni, L.L. Florio, R. Zampino, F. Mele, I. Gentile, B. Pinchera, N. Coppola, M. Pisaturo, R. Luzzati, N. Petrosillo, E. Nicastri, A. Corpolongo, M.A. Cataldo, A. D’Abramo, G. Maffongelli, L. Scorzolini, C. Palazzolo, E. Boumis, A. Pan, A. D’Arminio Monfort
Publié dans: International Journal of Infectious Diseases, Numéro 98, 2020, Page(s) 494-500, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/j.ijid.2020.06.082

Utilising long-read shotgun sequencing to study the lower respiratory tract microbiome from endotracheal aspirate samples

Auteurs: Juan Pablo Rodriguez Ruiz, Minh Nguyen Ngoc, Basil Britto Xavier, Jasmine Coppens, Christine Lammens, Veerle Matheeussen, Herman Goossens, Surbhi Malhotra-Kumar
Publié dans: 30th ECCMID abstract book, Numéro annual, 2020, Page(s) 2455
Éditeur: ESCMID

Meta-analysis of accuracy of rapid influenza antigen detection tests in community-care settings accounting for antigen type, setting, population and manufacturer

Auteurs: Elisa Gentilotti, Eleonora Cremonini, Pasquale De Nardo, Anna Gorska, Fulvia Mazzaferri, Mical Paul, Herman Goossens, Evelina Tacconelli
Publié dans: 30th ECCMID abstract book, Numéro annual, 2020, Page(s) 2227
Éditeur: ESCMID

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