The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use

Deliverables

Review of health-economic approaches and design of a generic modelling framework

Review of health-economic approaches for diagnostic-driven antibiotic use and design of a generic modelling framework to be applied in this project (continuously updated between months 12 to 48)

Database business plan
Recommendations for an innovative fit for purpose pricing and funding models for CA-ARTI-Dx

Recommendations for an innovative fit for purpose pricing and funding models for CAARTIDx

Review of pricing and reimbursement policies for CA-ARTI-Dx

Review of pricing and reimbursement policies for CA-ARTI-Dx in at least 15 European countries in country briefs

Clinical Algorithm for the diagnosis of CA-ARTI
Transferring results to the broader spectrum of EU Member States and H2020-associated countries.

Report on transferring results to the broader spectrum of EU Member States and H2020-associated countries.

User Requirement Specification Document for diagnostics of CA-ARTI;

User Requirement Specification Document for diagnostics of CA-ARTI

Policy recommendations, consensus report and a white paper;
key facilitators and barriers to adoption of CA-ARTI-Dx and policy and practice recommendations

Description of key facilitators and barriers to adoption of CAARTIDx and policy and practice recommendations for European community care setting

VALUE-Dx Business Plan and sustainability model, including implementation plan

VALUEDx Business Plan and sustainability model including implementation plan

Technological Roadmap for diagnostics of CA-ARTI
Health-economic model applied to CA-ARTI-Dx

Health-economic model applied to CA-ARTI-Dx, including base-case, sensitivity and scenario analysis on diagnostic strategies and their impact on AMR using the innovative health-economic model

Biobank business plan

VALUE-Dx Course

VALUE Dx Course, updated in motnhs 12 and 48

Media Toolkit
e-Portal App

E-Portal App

E-Portal

Publications

Stakeholders’ views and experiences on implementing new diagnostics in primary care to support management of community-acquired acute respiratory tract infections: a qualitative study

Author(s): Melanie Eugenie Hoste, Elien Colman, Marta Wanat, Gail Hayward, Jean-Louis Tissier, Maarten Postma, Herman Goossens, Sibyl Anthierens, Sarah Tonkin-Crine
Published in: Frontiers in Public Health, 2023
Publisher: Frontiers
DOI: 10.3389/fpubh.2023.1216940

Point prevalence audit surveys of respiratory tract infection consultations and antibiotic prescribing in primary care before and during the COVID-19 pandemic in Ireland

Author(s): M Shah; A Fleming; T M Barbosa; A W van der Velden; S Parveen; A Vellinga
Published in: Journal of Antimicrobial Chemotherapy, Issue 17, 2023, Page(s) 1270–1277
Publisher: Oxford Academic
DOI: 10.1093/jac/dkad088

Expert Guidance on Target Product Profile Development for AMR Diagnostic Tests

Author(s): Bachmann, T. T., Mitsakakis, K., Hays, J. P., van Belkum, A., Russom, A., Luedke, G., Simonsen, G. S., Abel, G., Peter, H., Goossens, H., Moran-Gilad, J., Vila, J., Becker, K., Moons, P., Sampath, R., Peeling, R., Luz, S., Van Staa, T. & Di Gregori, V.
Published in: BMJ Global Health, 2023, Page(s) 1-7
Publisher: BMJ
DOI: 10.1136/bmjgh-2023-012319

Towards Autonomous Living Meta-Analyses: A Framework for Automation of Systematic Review and Meta-Analysis

Author(s): Anna Górska, Evelina Tacconelli
Published in: Studies in health technology and informatics, 2024, Page(s) 378-382
Publisher: IOS Press
DOI: 10.3233/shti240427

Antibiotics and uncertainty of diagnosis in viral respiratory infections: Point-prevalence survey across 15 European countries

Author(s): PPAS4 Paediatric Group: Leila Khosravi, Dominic Imort, Manuel Gijon Mediavilla, Leila Ahmed, Emanuela Früh, Hanna Renk, Maggie Nyirenda Nyang'wa, Ratha Sritharan, Emily Bongard, Rune Aabenhus, Anca Balan, Femke Böhmer, Slawomir Chlabicz, Samuel Coenen, Ana García-Sangenís, Hrachuhi Ghazaryan, Christos Lionis, Sanne van der Linde, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Akke Vellinga,
Published in: Acta Paediatrica, 2023
Publisher: Wiley Online Library
DOI: 10.1111/apa.16855

Improving antibiotic prescribing - Recommendations for funding and pricing to enhance use of point-of-care tests

Author(s): Sabine Vogler, Caroline Steigenberger, Friederike Windisch
Published in: Health Policy Open, 2024
Publisher: Elsevier
DOI: 10.1016/j.hpopen.2024.100129

Assessing, Pricing and Funding Point-of-Care Diagnostic Tests for Community-Acquired Acute Respiratory Tract Infections–Overview of Policies Applied in 17 European Countries

Author(s): Sabine Vogler; Friederike Windisch
Published in: Antibiotics; Volume 11; Issue 8; Pages: 987, Issue 14, 2022
Publisher: MDPI
DOI: 10.3390/antibiotics11080987

Point-of-care testing, antibiotic prescribing, and prescribing confidence for respiratory tract infections in primary care: a prospective audit in 18 European countries

Author(s): Alike W. van der Velden, Alma C. van de Pol, Emily Bongard, Daniela Cianci, Rune Aabenhus, Anca Balan, Femke Böhmer, Valerija Bralic Lang, Pascale Bruno, Slawomir Chlabicz, Samuel Coenen, Annelies Colliers, Anna Garcia-Sangenis, Hrachuhi Ghazaryan, Mciek Godycki-Cwirko , Siri Jensen, Christos Lionis, Sanne van der Linde, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Akke Vellinga, Ihor Zastavn
Published in: BGJP Open, 2021
Publisher: Royal College of General Practitioners
DOI: 10.3399/bjgpo.2021.0212

Using point-of-care diagnostic testing for improved antibiotic prescription: an economic model

Author(s): Antoñanzas F, Juárez C, Rodríguez R
Published in: Health Economics Review, 2021
Publisher: Nature Springer
DOI: 10.1186/s13561-021-00326-y

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Author(s): Rojas García P, van der Pol S, van Asselt ADI, et al.
Published in: Antibiotics, 2022
Publisher: MDPI
DOI: 10.3390/antibiotics11010027

The Opportunity of Point-of-Care Diagnostics in General Practice: Modelling the Effects on Antimicrobial Resistance

Author(s): van der Pol, S., Jansen, D. E., van der Velden, A. W., Butler, C. C., Verheij, T. J., Friedrich, A. W., van Asselt, A. D.
Published in: Pharmacoeconomics, 2022
Publisher: Springer
DOI: 10.1007/s40273-022-01165-3

European wide benchmarking of disease-specific quality indicators for outpatient antibiotic prescribing for respiratory infections: ESAC quality indicators applied to point prevalence audit surveys in 13 European countries

Author(s): Akke Vellinga, Addiena Luke-Currier, Nathaly Garzón-Orjuela, Rune Aabenhus, Marilena Anastasaki, Anca Balan, Femke Böhmer, Valerija Bralić Lang, Slawomir Chlabicz, Samuel Coenen, Ana García-Sangenís, Anna Kowalczyk, Lile Malania, Angela Tomacinschii, Sanne R. van der Linde, Emily Bongard, Christopher C. Butler, Herman Goossens, Alike W. van der Velden
Published in: Antibiotics, 2023
Publisher: Nature Publishing Group
DOI: 10.3390/antibiotics12030572

Systematic review and meta-analysis of diagnostics accuracy in community-acquired acute respiratory tract infections (protocol)

Author(s): Pasquale De Nardo, Elisa Gentilotti, Eleonora Cremonini, Fulvia Mazzaferri, Anna Gorska, Evelina Tacconelli, Mical Paul, Muna Mustafa, Till Bachmann, Christopher Butler, Samuel Coenen, Gail Hayward, Jorge Villacian, Herman Goossens, Itamar Poran
Published in: PROSPERO - International Prospective Register of Systematic Reviews, 2019
Publisher: National Institute for Health Research - University of York

Usability of OMOP Common Data Model for Detailed Lab Microbiology Results

Author(s): E. Theron, JF Gorse, X. Gansel
Published in: Studies in Health Technology and Informatics, 2022
Publisher: IOS Press
DOI: 10.3233/shti220461

Barriers and Facilitators in Pricing and Funding Policies of European Countries That Impact the Use of Point-of-Care Diagnostics for Acute Respiratory Tract Infections in Outpatient Practices

Author(s): Caroline Steigenberger; Friederike Windisch; Sabine Vogler
Published in: Diagnostics, Vol 13, Iss 23, p 3596 (2023), Issue 15, 2023
Publisher: MDPI
DOI: 10.3390/diagnostics13233596

Does diagnostic testing always decrease antibiotics prescriptions?

Author(s): F. Antoñanzas, C. A. Juárez‑Castelló, R. Rodríguez‑Ibeas
Published in: The European Journal of Health Economics, 2022
Publisher: Springer Nature
DOI: 10.1007/s10198-022-01488-0

Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections. A systematic review and meta-analysis

Author(s): Gentilotti, E. et al
Published in: Clinical Microbiology and Infection, 2021
Publisher: ESCMID
DOI: 10.1016/j.cmi.2021.09.025

Randomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections—trial protocol for the ADEQUATE Paediatric trial

Author(s): ADEQUATE Paediatric Trial Group
Published in: BMJ Open, 2024
Publisher: BMJ
DOI: 10.1136/bmjopen-2023-076338

Primary care for patients with respiratory tract infection before and early on in the COVID-19 pandemic: an observational study in 16 European countries

Author(s): Alike W van der Velden, Eva A Bax, Emily Bongard, Rune Munck Aabenhus, Marilena Anastasaki, Sibyl Anthierens, Anca Balan, Femke Böhmer, Pascale Bruno, Slawomir Chlabicz, Samuel Coenen, Annelies Colliers, Susanne Emmerich, Ana Garcia-Sangenis, Hrachuhi Ghazaryan, Sanne R van der Linde, Lile Malania, József Pauer, Angela Tomacinschii, Sarah Tonkin-Crine, Akke Vellinga, Ihor Zastavnyy, Theo Verheij
Published in: BMJ Open, Issue 11/7, 2021, Page(s) e049257, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-049257

Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting

Author(s): Simon van der Pol, Paula Rojas Garcia, Fernando Antoñanzas Villar, Maarten J. Postma, Antoinette D. I. van Asselt
Published in: PharmacoEconomics, 2021, ISSN 1170-7690
Publisher: Adis International Ltd.
DOI: 10.1007/s40273-021-01104-8

Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review

Author(s): Paula Rojas García, Simon van der Pol, Antoinette D. I. van Asselt, Maarten Postma, Roberto Rodríguez-Ibeas, Carmelo A. Juárez-Castelló, Marino González, Fernando Antoñanzas
Published in: Antibiotics, Issue 10/1, 2021, Page(s) 55, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics10010055

Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review

Author(s): Simon van der Pol, Paula Rojas Garcia, Maarten J. Postma, Fernando Antoñanzas Villar, Antoinette D. I. van Asselt
Published in: PharmacoEconomics, Issue online, 2021, Page(s) online, ISSN 1170-7690
Publisher: Adis International Ltd.
DOI: 10.1007/s40273-021-01054-1

Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis

Author(s): Mona Mustafa Hellou, Anna Górska, Fulvia Mazzaferri, Eleonora Cremonini, Elisa Gentilotti, Pasquale De Nardo, Itamar Poran, Mariska M. Leeflang, Evelina Tacconelli, Mical Paul
Published in: Clinical Microbiology and Infection, Issue 27/3, 2021, Page(s) 341-351, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2020.11.002

Multi-Criteria Decision Analysis to prioritize hospital admission of patients affected by COVID-19 in low-resource settings with hospital-bed shortage

Author(s): Pasquale De Nardo, Elisa Gentilotti, Fulvia Mazzaferri, Eleonora Cremonini, Paul Hansen, Herman Goossens, Evelina Tacconelli, E. Durante Mangoni, L.L. Florio, R. Zampino, F. Mele, I. Gentile, B. Pinchera, N. Coppola, M. Pisaturo, R. Luzzati, N. Petrosillo, E. Nicastri, A. Corpolongo, M.A. Cataldo, A. D’Abramo, G. Maffongelli, L. Scorzolini, C. Palazzolo, E. Boumis, A. Pan, A. D’Arminio Monfort
Published in: International Journal of Infectious Diseases, Issue 98, 2020, Page(s) 494-500, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2020.06.082

Utilising long-read shotgun sequencing to study the lower respiratory tract microbiome from endotracheal aspirate samples

Author(s): Juan Pablo Rodriguez Ruiz, Minh Nguyen Ngoc, Basil Britto Xavier, Jasmine Coppens, Christine Lammens, Veerle Matheeussen, Herman Goossens, Surbhi Malhotra-Kumar
Published in: 30th ECCMID abstract book, Issue annual, 2020, Page(s) 2455
Publisher: ESCMID

Meta-analysis of accuracy of rapid influenza antigen detection tests in community-care settings accounting for antigen type, setting, population and manufacturer

Author(s): Elisa Gentilotti, Eleonora Cremonini, Pasquale De Nardo, Anna Gorska, Fulvia Mazzaferri, Mical Paul, Herman Goossens, Evelina Tacconelli
Published in: 30th ECCMID abstract book, Issue annual, 2020, Page(s) 2227
Publisher: ESCMID

Deliverables

Publications

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