Biomarkers in Atopic Dermatitis and Psoriasis

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BIOMAP protocol, SOPs and training material
Map of ethical-legal implications of work in BIOMAP
BIOMAP glossary compiled
Results from single layer whole blood/skin differential (EWAS/TWAS) analysis

Results from single layer whole bloodskin differential EWASTWAS analysis

Overview of state-of-the-art and guide how to investigate and integrate biomarker research

Overview of stateoftheart and guide how to investigate and integrate biomarker research

Project clip
Project Website

Publications

Host traits, lifestyle and environment are associated with the human skin bacteria

Auteurs: L. Moitinho‐Silva, N. Boraczynski, H. Emmert, H. Baurecht, S. Szymczak, H. Schulz, D. Haller, J. Linseisen, C. Gieger, A. Peters, L. Tittmann, W. Lieb, C. Bang, A. Franke, E. Rodriguez, S. Weidinger
Publié dans: British Journal of Dermatology, 2021, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20072

Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis

Auteurs: Lena Möbus, Elke Rodriguez, Inken Harder, Agatha Schwarz, Ulrike Wehkamp, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Thomas Litman, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Jochen Schmitt, Thomas Werfel, Stephan Weidinger
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 147/5, 2021, Page(s) 1959-1965.e2, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2020.11.022

Imputation provides an opportunity to study FLG null mutations in large population cohorts without bespoke genotyping

Auteurs: Lavinia Paternoster, Ashley Budu-Aggrey, Sara J. Brown
Publié dans: Wellcome Open Research, 2022, ISSN 2398-502X
Éditeur: Wellcome Trust
DOI: 10.12688/wellcomeopenres.17657.1

Biomarkers of disease progression in people with psoriasis: a scoping review

Auteurs: Ravi Ramessur, Mark Corbett, David Marshall, Marcio L. Acencio, Ines A. Barbosa, Nick Dand, Paola Di Meglio, Salma Haddad, Andreas H.M. Jensen, Witte Koopmann, Satveer K. Mahil, Marek Ostaszewski, Seher Rahmatulla, Joe Rastrick, Jake Saklatvala, Stephan Weidinger, Kath Wright, Kilian Eyerich, Matladi Ndlovu, Jonathan N. Barker, Lone Skov, Curdin Conrad, Catherine H Smith, The BIOMAP consortium
Publié dans: British Journal of Dermatology, 2022, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.21627

The BIOMarkers in Atopic Dermatitis and Psoriasis (BIOMAP) glossary: developing a lingua franca to facilitate data harmonization and cross-cohort analyses

Auteurs: C. Broderick, N. Christian, C. Apfelbacher, A.L. Bosma, N. Dand, S. Ghosh, N. Hangel, M. Hübenthal, M.A. Middelkamp-Hup, J.L. Min, A.H. Musters, L. Paternoster, E. Rodríguez, V. Satagopam, P. Scordis, P.I. Spuls, S. Szymczak, S. Weidinger, C.H. Smith, C. Flohr, on behalf of the BIOMAP consortium
Publié dans: British Journal of Dermatology, 2021, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20587

The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis

Auteurs: Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis & Dario Greco
Publié dans: Human Genomics, 2022, ISSN 1479-7364
Éditeur: BMC
DOI: 10.1186/s40246-022-00431-x

Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Auteurs: Lucas Moitinho-Silva, Frauke Degenhardt, Elke Rodriguez, Hila Emmert, Simonas Juzenas, Lena Möbus, Florian Uellendahl-Werth, Nicole Sander, Hansjörg Baurecht, Lukas Tittmann, Wolfgang Lieb, Christian Gieger, Annette Peters, David Ellinghaus, Corinna Bang, Andre Franke, Stephan Weidinger & Malte Christoph Rühlemann
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-33906-5

Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome

Auteurs: Hila Emmert, Hansjörg Baurecht, Frederieke Thielking, Dora Stölzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Publié dans: Experimental Dermatology, 2020, ISSN 0906-6705
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/exd.14185

Requirements and expectations of high-quality biomarkers for atopic dermatitis and psoriasis in 2021-a two-round Delphi survey among international experts

Auteurs: S. Ziehfreund, L. Tizek, N. Hangel, M.-C. Fritzsche, S. Weidinger, C. Smith, P.J Bryce, D. Greco, E.H van den Bogaard, C. Flohr, J. Rastrick, S. Eyerich, A. Buyx, C. Conrad, K. Eyerich, A. Zink
Publié dans: Journal of the European Academy of Dermatology and Venereology (JEADV), 2022, ISSN 1468-3083
Éditeur: Wiley-Blackwell
DOI: 10.1111/jdv.18178

Mass Cytometric Analysis of Early-Stage Mycosis Fungoides

Auteurs: Nannan Guo, Li Jia, Coby Out-Luiting, Noel F. C. C. de Miranda, Rein Willemze , Frits Koning, Maarten Vermeer and Koen Quint
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells11071062

Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis

Auteurs: Helen Vaher, Kristiina Kingo, Peep Kolberg, Martin Pook, Liisi Raam, Anet Laanesoo, Anu Remm, Tanel Tenson, Kaur Alasoo, Ulrich Mrowietz, Stephan Weidinger, Külli Kingo, Ana Rebane
Publié dans: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.01.013

Mapping ethical and social aspects of biomarker research and its application in atopic dermatitis and psoriasis: a systematic review of reason

Auteurs: M.-Ch. Fritzsche, A.M. Buyx, N. Hangel
Publié dans: Journal of the European Academy of Dermatology and Venereology (JEADV), 2022, ISSN 1468-3083
Éditeur: Wiley-Blackwell
DOI: 10.1111/jdv.18128

Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes

Auteurs: Jos P.H. Smits, Noa J.M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A.M. Jansen, Ivonne M.J.J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Céline Evrard, Yves Poumay, Michel van Geel, Wiljan J.A.J. Hendriks, Joost Schalkwijk, Patrick L.J.M. Zeeuwen, Ellen H. van den Bogaard
Publié dans: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.02.021

Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate-to-severe atopic dermatitis

Auteurs: Jan Hartmann, Lucas Moitinho-Silva, Nicole Sander, Inken Harder, Robert Häsler, Elke Rodriguez, Eva Haufe, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Elke Weisshaar, Knut Schäkel, Christiane Handrick, Matthias Augustin, Andreas Wollenberg, Petra Staubach-Renz, Konstantin Ertner, Michael Sticherling, Beate Schwarz, Sven Quist, Franca Wiemers, Florian Schenck, Julia Wildberger, Lukas
Publié dans: Allergy, 2023, ISSN 1398-9995
Éditeur: John Wiley and Sons, Ltd
DOI: 10.1111/all.15742

Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites

Auteurs: Noora Ottman, Mauricio Barrientos‐Somarribas, Nanna Fyhrquist, Helen Alexander, Lukas Wisgrill, Peter Olah, Sophia Tsoka, Dario Greco, Francesca Levi‐Schaffer, Vassili Soumelis, Jens M. Schröder, Juha Kere, Frank O. Nestle, Jonathan Barker, Annamari Ranki, Antti Lauerma, Bernhard Homey, Björn Andersson, Harri Alenius
Publié dans: Allergy, Numéro 76/4, 2021, Page(s) 1173-1187, ISSN 0105-4538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/all.14606

Gut microbiota development during infancy: Impact of introducing allergenic foods

Auteurs: Tom Marrs, Jay-Hyun Jo, Michael R. Perkin, Damian W. Rivett, Adam A. Witney, Kenneth D. Bruce, Kirsty Logan, Joanna Craven, Suzana Radulovic, Serge A. Versteeg, Ronald van Ree, W. H. Irwin McLean, David P. Strachan, Gideon Lack, Heidi H. Kong, Carsten Flohr
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 147/2, 2021, Page(s) 613-621.e9, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2020.09.042

The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases

Auteurs: Harri Alenius, Hanna Sinkko, Lucas Moitinho-Silva, Elke Rodriguez, Conor Broderick, Helen Alexander, Matthias Reiger, Mathis Hjort Hjelmsø, Nanna Fyhrquist, Peter Olah, Paul Bryce, Catherine Smith, Frits Koning, Kilian Eyerich, Dario Greco, Ellen H. van den Bogaard, Avidan U. Neumann, Claudia Traidl-Hoffmann, Bernhard Homey, Carsten Flohr, Klaus Bønnelykke, Jakob Stokholm, Stephan Weidinger
Publié dans: Experimental Dermatology, 2021, ISSN 1600-0625
Éditeur: Wiley-Blackwell
DOI: 10.1111/exd.14446

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

Auteurs: Lena Möbus, Elke Rodriguez, Inken Harder, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 147/1, 2021, Page(s) 213-223, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2020.06.012

Biomarkers of systemic treatment response in people with psoriasis: a scoping review

Auteurs: Mark Corbett, Ravi Ramessur, David Marshall, Marcio L. Acencio, Marek Ostaszewski, Ines A. Barbosa, Nick Dand, Paola Di Meglio, Salma Haddad, Andreas H.M. Jensen, Witte Koopmann, Satveer K. Mahil, Seher Rahmatulla, Joe Rastrick, Jake Saklatvala, Stephan Weidinger, Kath Wright, Kilian Eyerich, Jonathan N. Barker, Matladi Ndlovu, Curdin Conrad, Lone Skov, Catherine H. Smith, on behalf of the BIOMAP
Publié dans: British Journal of Dermatology, 2022, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.21677

Blood transcriptome profiling identifies two candidate endotypes of atopic dermatitis

Auteurs: Lena Möbus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Hübenthal, Dora Stölzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger, Biomap and the TREATgermany study group
Publié dans: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2022.02.001

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression

Auteurs: Sören Mucha, Hansjörg Baurecht, Natalija Novak, Elke Rodríguez, Saptarshi Bej, Gabriele Mayr, Hila Emmert, Dora Stölzl, Sascha Gerdes, Eun Suk Jung, Frauke Degenhardt, Matthias Hübenthal, Eva Ellinghaus, Jan Christian Kässens, Lars Wienbrandt, Wolfgang Lieb, Martina Müller-Nurasyid, Melanie Hotze, Nick Dand, Sarah Grosche, Ingo Marenholz, Andreas Arnold, Georg Homuth, Carsten O. Schmidt, Ul
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 145/4, 2020, Page(s) 1208-1218, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2019.10.030

Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses

Auteurs: Lam C. Tsoi, Elke Rodriguez, Dora Stölzl, Ulrike Wehkamp, Jingru Sun, Sascha Gerdes, Mrinal K. Sarkar, Matthias Hübenthal, Chang Zeng, Ranjitha Uppala, Xianying Xing, Frederieke Thielking, Allison C. Billi, William R. Swindell, Alanna Shefler, Jiahan Chen, Matthew T. Patrick, Paul W. Harms, J. Michelle Kahlenberg, Bethany E. Perez White, Emanual Maverakis, Johann E. Gudjonsson, Stephan Weidinger
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 145/5, 2020, Page(s) 1406-1415, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2019.11.047

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis

Auteurs: Michael Koch, Tobias Kockmann, Elke Rodriguez, Ulrike Wehkamp, Paul Hiebert, Maya Ben-Yehuda Greenwald, Dora Stölzl, Hans-Dietmar Beer, Erwin Tschachler, Stephan Weidinger, Sabine Werner, Ulrich auf dem Keller
Publié dans: Journal of Investigative Dermatology, 2022, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2022.08.048

Differences in clinical features and comorbid burden between HLA-C*06:02 carrier groups in 9,000 psoriasis patients

Auteurs: Konstantinos Douroudis, Ravi Ramessur, Ines A. Barbosa, David Baudry, Michael Duckworth, Caroline Angit, Francesca Capon, Raymond Chung, Charles J. Curtis, Paola Di Meglio, Jonathan MR. Goulding, Christopher EM. Griffiths, Sang Hyuck Lee, Satveer K. Mahil, Richard Parslew, Nick J. Reynolds, Alexa R. Shipman, Richard B. Warren, Zenas ZN. Yiu, BADBIR Study Group, BSTOP Study Group, Michael A. Simpso
Publié dans: Journal of Investigative Dermatology, 2021, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2021.08.446

miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar

Auteurs: Gemma Carreras-Badosa, Julia Maslovskaja, Helen Vaher, Laura Pajusaar, Tarmo Annilo, Freddy Lättekivi, Matthias Hübenthal, Elke Rodriguez, Stephan Weidinger, Külli Kingo & Ana Rebane
Publié dans: Scientific Reports, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-27235-2

Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis

Auteurs: Amy R. Mulick, Alasdair D. Henderson, David Prieto-Merino, Kathryn E. Mansfield, Julian Matthewman, Jennifer K. Quint, Ronan A. Lyons, Aziz Sheikh, David A. McAllister, Dorothea Nitsch & Sinéad M. Langan
Publié dans: Scientific Reports, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-26357-x

Manually curated and harmonised transcriptomics datasets of psoriasis and atopic dermatitis patients

Auteurs: Antonio Federico, Veera Hautanen, Nils Christian, Andreas Kremer, Angela Serra, Dario Greco
Publié dans: Scientific Data, Numéro 7/1, 2020, ISSN 2052-4463
Éditeur: Springer Nature
DOI: 10.1038/s41597-020-00696-8

Microbe-host interplay in atopic dermatitis and psoriasis

Auteurs: Nanna Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Hanna Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari Suomela, Ioannis Tessas, Emilia Lybeck, Anna
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-12253-y

Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies

Auteurs: Jake R. Saklatvala, Ken B. Hanscombe, Satveer K. Mahil, Lam C. Tsoi, James T. Elder, Jonathan N. Barker, Michael A. Simpson, Catherine H. Smith, Nick Dand
Publié dans: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.02.010

Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review

Auteurs: Conor Broderick, Stefanie Ziehfreund, Karin van Bart, Bernd Arents, Kilian Eyerich, Stephan Weidinger, Joseph Rastrick, Alexander Zink, Carsten Flohr, BIOMAP Consortium
Publié dans: Allergy, 2022, ISSN 1398-9995
Éditeur: John Wiley and Sons, Ltd
DOI: 10.1111/all.15578

Keratinocyte signaling in atopic dermatitis: Investigations in organotypic skin models toward clinical application

Auteurs: Luca D. Meesters, Hanna Niehues, Luke Johnston, Jos P. H. Smits, Patrick L. J. M. Zeeuwen, Sara J. Brown and Ellen H. van den Bogaard
Publié dans: Journal of Allergy and Clinical Immunology, 2023, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2023.02.012

Transcriptome profiling identifies disease- and therapy-associated signatures in atopic dermatitis

Auteurs: Möbus, Lena
Publié dans: urn:nbn:de:gbv:8:3-2021-00674-5, 2021
Éditeur: University of Kiel

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