Biomarkers in Atopic Dermatitis and Psoriasis

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

BIOMAP protocol, SOPs and training material
Map of ethical-legal implications of work in BIOMAP
BIOMAP glossary compiled
Results from single layer whole blood/skin differential (EWAS/TWAS) analysis

Results from single layer whole bloodskin differential EWASTWAS analysis

Overview of state-of-the-art and guide how to investigate and integrate biomarker research

Overview of stateoftheart and guide how to investigate and integrate biomarker research

Project clip
Project Website

Publications

Host traits, lifestyle and environment are associated with the human skin bacteria

Author(s): L. Moitinho‐Silva, N. Boraczynski, H. Emmert, H. Baurecht, S. Szymczak, H. Schulz, D. Haller, J. Linseisen, C. Gieger, A. Peters, L. Tittmann, W. Lieb, C. Bang, A. Franke, E. Rodriguez, S. Weidinger
Published in: British Journal of Dermatology, 2021, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20072

Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis

Author(s): Lena Möbus, Elke Rodriguez, Inken Harder, Agatha Schwarz, Ulrike Wehkamp, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Thomas Litman, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Jochen Schmitt, Thomas Werfel, Stephan Weidinger
Published in: Journal of Allergy and Clinical Immunology, Issue 147/5, 2021, Page(s) 1959-1965.e2, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2020.11.022

Imputation provides an opportunity to study FLG null mutations in large population cohorts without bespoke genotyping

Author(s): Lavinia Paternoster, Ashley Budu-Aggrey, Sara J. Brown
Published in: Wellcome Open Research, 2022, ISSN 2398-502X
Publisher: Wellcome Trust
DOI: 10.12688/wellcomeopenres.17657.1

A Multi‐Dimensional Approach to Map Disease Relationships Challenges Classical Disease Views

Author(s): Lena Möbus, Angela Serra, Michele Fratello, Alisa Pavel, Antonio Federico, Dario Greco
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202401754

Biomarkers of disease progression in people with psoriasis: a scoping review

Author(s): Ravi Ramessur, Mark Corbett, David Marshall, Marcio L. Acencio, Ines A. Barbosa, Nick Dand, Paola Di Meglio, Salma Haddad, Andreas H.M. Jensen, Witte Koopmann, Satveer K. Mahil, Marek Ostaszewski, Seher Rahmatulla, Joe Rastrick, Jake Saklatvala, Stephan Weidinger, Kath Wright, Kilian Eyerich, Matladi Ndlovu, Jonathan N. Barker, Lone Skov, Curdin Conrad, Catherine H Smith, The BIOMAP consortium
Published in: British Journal of Dermatology, 2022, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.21627

The BIOMarkers in Atopic Dermatitis and Psoriasis (BIOMAP) glossary: developing a lingua franca to facilitate data harmonization and cross-cohort analyses

Author(s): C. Broderick, N. Christian, C. Apfelbacher, A.L. Bosma, N. Dand, S. Ghosh, N. Hangel, M. Hübenthal, M.A. Middelkamp-Hup, J.L. Min, A.H. Musters, L. Paternoster, E. Rodríguez, V. Satagopam, P. Scordis, P.I. Spuls, S. Szymczak, S. Weidinger, C.H. Smith, C. Flohr, on behalf of the BIOMAP consortium
Published in: British Journal of Dermatology, 2021, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20587

Disagreement concerning atopic dermatitis subtypes between an English prospective cohort (ALSPAC) and linked electronic health records

Author(s): Julian Matthewman, Amy Mulick, Nick Dand, Daniel Major-Smith, Alasdair Henderson, Neil Pearce, Spiros Denaxas, Rita Iskandar, Amanda Roberts, Rosie P Cornish, Sara J Brown, Lavinia Paternoster, Sinéad M Langan
Published in: Clinical and Experimental Dermatology, 2024, ISSN 0307-6938
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/ced/llae196

The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis

Author(s): Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis & Dario Greco
Published in: Human Genomics, 2022, ISSN 1479-7364
Publisher: BMC
DOI: 10.1186/s40246-022-00431-x

Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK

Author(s): Alasdair D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. Smith, Joseph Hayes, Kathryn E. Mansfield & Sinéad M. Langan
Published in: BMC Medicine, 2023, ISSN 1472-6963
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02948-x

Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research- an inter-disciplinary perspective

Author(s): Ravi Ramessur, Nick Dand, Sinéad M Langan, Jake Saklatvala, Marie-Christine Fritzsche, Suzi Holland, Bernd W M Arents, Helen McAteer, Andrew Proctor, David McMahon, Michelle Greenwood, Alena M Buyx, Tamara Messer, Nina Weiler, Alexandra Hicks, Peter Hecht, Stephan Weidinger, Matladi N Ndlovu, Dai Chengliang, Matthias Hübenthal, Alexander Egeberg, Lavinia Paternoster, Lone Skov, Elke M G J De Jon
Published in: British Journal of Dermatology, 2024, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/bjd/ljae080

Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Author(s): Lucas Moitinho-Silva, Frauke Degenhardt, Elke Rodriguez, Hila Emmert, Simonas Juzenas, Lena Möbus, Florian Uellendahl-Werth, Nicole Sander, Hansjörg Baurecht, Lukas Tittmann, Wolfgang Lieb, Christian Gieger, Annette Peters, David Ellinghaus, Corinna Bang, Andre Franke, Stephan Weidinger & Malte Christoph Rühlemann
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33906-5

Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome

Author(s): Hila Emmert, Hansjörg Baurecht, Frederieke Thielking, Dora Stölzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Published in: Experimental Dermatology, 2020, ISSN 0906-6705
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/exd.14185

Requirements and expectations of high-quality biomarkers for atopic dermatitis and psoriasis in 2021-a two-round Delphi survey among international experts

Author(s): S. Ziehfreund, L. Tizek, N. Hangel, M.-C. Fritzsche, S. Weidinger, C. Smith, P.J Bryce, D. Greco, E.H van den Bogaard, C. Flohr, J. Rastrick, S. Eyerich, A. Buyx, C. Conrad, K. Eyerich, A. Zink
Published in: Journal of the European Academy of Dermatology and Venereology (JEADV), 2022, ISSN 1468-3083
Publisher: Wiley-Blackwell
DOI: 10.1111/jdv.18178

Mass Cytometric Analysis of Early-Stage Mycosis Fungoides

Author(s): Nannan Guo, Li Jia, Coby Out-Luiting, Noel F. C. C. de Miranda, Rein Willemze , Frits Koning, Maarten Vermeer and Koen Quint
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells11071062

Investigating the genetic basis of the influence of adiposity on psoriasis

Author(s): Ravi Ramessur, Jake Saklatvala, Mari Loset, Laurent Thomas, Ashley Budu-Aggrey, Satveer K Mahil, Jonathan N Barker, Nick Dand, Michael A Simpson, Catherine H Smith
Published in: Journal of Investigative Dermatology, 2025, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2025.03.024

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Author(s): Nick Dand, Philip E. Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R. Saklatvala, Maris Teder-Laving, Laurent F. Thomas, Tanel Traks, Steffen Uebe, Gunter Assmann, David Baudry, Frank Behrens, Allison C. Billi, Matthew A. Brown, Harald Burkhardt, Francesca Capon, Raymond Chung, Charles J. Curtis, Michael Duckworth, Eva Ellinghaus, Oliver FitzGerald, Sascha Gerdes, Christopher E. M. G
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56719-8

Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis

Author(s): Helen Vaher, Kristiina Kingo, Peep Kolberg, Martin Pook, Liisi Raam, Anet Laanesoo, Anu Remm, Tanel Tenson, Kaur Alasoo, Ulrich Mrowietz, Stephan Weidinger, Külli Kingo, Ana Rebane
Published in: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.01.013

Mapping ethical and social aspects of biomarker research and its application in atopic dermatitis and psoriasis: a systematic review of reason

Author(s): M.-Ch. Fritzsche, A.M. Buyx, N. Hangel
Published in: Journal of the European Academy of Dermatology and Venereology (JEADV), 2022, ISSN 1468-3083
Publisher: Wiley-Blackwell
DOI: 10.1111/jdv.18128

Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes

Author(s): Jos P.H. Smits, Noa J.M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A.M. Jansen, Ivonne M.J.J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Céline Evrard, Yves Poumay, Michel van Geel, Wiljan J.A.J. Hendriks, Joost Schalkwijk, Patrick L.J.M. Zeeuwen, Ellen H. van den Bogaard
Published in: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.02.021

Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate-to-severe atopic dermatitis

Author(s): Jan Hartmann, Lucas Moitinho-Silva, Nicole Sander, Inken Harder, Robert Häsler, Elke Rodriguez, Eva Haufe, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Elke Weisshaar, Knut Schäkel, Christiane Handrick, Matthias Augustin, Andreas Wollenberg, Petra Staubach-Renz, Konstantin Ertner, Michael Sticherling, Beate Schwarz, Sven Quist, Franca Wiemers, Florian Schenck, Julia Wildberger, Lukas
Published in: Allergy, 2023, ISSN 1398-9995
Publisher: John Wiley and Sons, Ltd
DOI: 10.1111/all.15742

Weighing the benefits and risks of collecting race and ethnicity data in clinical settings for medical artificial intelligence

Author(s): Amelia Fiske, Sarah Blacker, Lester Darryl Geneviève, Theresa Willem, Marie-Christine Fritzsche, Alena Buyx, Leo Anthony Celi, Stuart McLennan
Published in: The Lancet Digital Health, Issue 7, 2025, Page(s) e286-e294, ISSN 2589-7500
Publisher: Elsevier BV
DOI: 10.1016/j.landig.2025.01.003

Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites

Author(s): Noora Ottman, Mauricio Barrientos‐Somarribas, Nanna Fyhrquist, Helen Alexander, Lukas Wisgrill, Peter Olah, Sophia Tsoka, Dario Greco, Francesca Levi‐Schaffer, Vassili Soumelis, Jens M. Schröder, Juha Kere, Frank O. Nestle, Jonathan Barker, Annamari Ranki, Antti Lauerma, Bernhard Homey, Björn Andersson, Harri Alenius
Published in: Allergy, Issue 76/4, 2021, Page(s) 1173-1187, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14606

Embedded Ethics in Practice: A Toolbox for Integrating the Analysis of Ethical and Social Issues into Healthcare AI Research

Author(s): Theresa Willem, Marie-Christine Fritzsche, Bettina M. Zimmermann, Anna Sierawska, Svenja Breuer, Maximilian Braun, Anja K. Ruess, Marieke Bak, Franziska B. Schönweitz, Lukas J. Meier, Amelia Fiske, Daniel Tigard, Ruth Müller, Stuart McLennan, Alena Buyx
Published in: Science and Engineering Ethics, Issue 31, 2025, ISSN 1471-5546
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11948-024-00523-y

Gut microbiota development during infancy: Impact of introducing allergenic foods

Author(s): Tom Marrs, Jay-Hyun Jo, Michael R. Perkin, Damian W. Rivett, Adam A. Witney, Kenneth D. Bruce, Kirsty Logan, Joanna Craven, Suzana Radulovic, Serge A. Versteeg, Ronald van Ree, W. H. Irwin McLean, David P. Strachan, Gideon Lack, Heidi H. Kong, Carsten Flohr
Published in: Journal of Allergy and Clinical Immunology, Issue 147/2, 2021, Page(s) 613-621.e9, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2020.09.042

Digital endpoints in clinical trials: emerging themes from a multi-stakeholder Knowledge Exchange event

Author(s): Mia S. Tackney, Amber Steele, Joseph Newman, Marie-Christine Fritzsche, Federica Lucivero, Zarnie Khadjesari, Jennifer Lynch, Rosemary A. Abbott, Vicki S. Barber, James R. Carpenter, Bethan Copsey, Elin H. Davies, William G. Dixon, Lisa Fox, Javier González, Jessica Griffiths, Chloe H. L. Hinchliffe, Magdalena A. Kolanko, Dylan McGagh, Aryelly Rodriguez, George Roussos, Karen B. E. So, Louise Sta
Published in: Trials, Issue 25, 2024, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-024-08356-7

The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers – A qualitative expert interview study in dermatology research

Author(s): Nora Hangel, Alena Buyx, Marie-Christine Fritzsche
Published in: Heliyon, Issue 10, 2025, Page(s) e31723, ISSN 2405-8440
Publisher: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e31723

The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases

Author(s): Harri Alenius, Hanna Sinkko, Lucas Moitinho-Silva, Elke Rodriguez, Conor Broderick, Helen Alexander, Matthias Reiger, Mathis Hjort Hjelmsø, Nanna Fyhrquist, Peter Olah, Paul Bryce, Catherine Smith, Frits Koning, Kilian Eyerich, Dario Greco, Ellen H. van den Bogaard, Avidan U. Neumann, Claudia Traidl-Hoffmann, Bernhard Homey, Carsten Flohr, Klaus Bønnelykke, Jakob Stokholm, Stephan Weidinger
Published in: Experimental Dermatology, 2021, ISSN 1600-0625
Publisher: Wiley-Blackwell
DOI: 10.1111/exd.14446

DREAM: an R package for druggability evaluation of human complex diseases

Author(s): Antonio Federico, Michele Fratello, Alisa Pavel, Lena Möbus, Giusy del Giudice, Angela Serra, Dario Greco
Published in: Bioinformatics, 2023, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1093/bioinformatics/btad442

Integrative network analysis suggests prioritised drugs for atopic dermatitis

Author(s): Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist & Dario Greco
Published in: Journal of Translational Medicine, 2024, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-04879-4

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

Author(s): Lena Möbus, Elke Rodriguez, Inken Harder, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Published in: Journal of Allergy and Clinical Immunology, Issue 147/1, 2021, Page(s) 213-223, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2020.06.012

Biomarkers of systemic treatment response in people with psoriasis: a scoping review

Author(s): Mark Corbett, Ravi Ramessur, David Marshall, Marcio L. Acencio, Marek Ostaszewski, Ines A. Barbosa, Nick Dand, Paola Di Meglio, Salma Haddad, Andreas H.M. Jensen, Witte Koopmann, Satveer K. Mahil, Seher Rahmatulla, Joe Rastrick, Jake Saklatvala, Stephan Weidinger, Kath Wright, Kilian Eyerich, Jonathan N. Barker, Matladi Ndlovu, Curdin Conrad, Lone Skov, Catherine H. Smith, on behalf of the BIOMAP
Published in: British Journal of Dermatology, 2022, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.21677

Mapping SCORing of Atopic Dermatitis (SCORAD) and objective SCORAD to the Eczema Area and Severity Index to facilitate large-scale meta-analyses of molecular data

Author(s): Matthias Hübenthal, Chengliang Dai, Sara J Brown, Luise Heinrich, Barbara Kind, Inken Harder, Jochen Schmitt, Thomas Werfel, Stephan Weidinger
Published in: British Journal of Dermatology, Issue 191, 2024, Page(s) 637-639, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/bjd/ljae232

Blood transcriptome profiling identifies two candidate endotypes of atopic dermatitis

Author(s): Lena Möbus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Hübenthal, Dora Stölzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger, Biomap and the TREATgermany study group
Published in: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.02.001

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression

Author(s): Sören Mucha, Hansjörg Baurecht, Natalija Novak, Elke Rodríguez, Saptarshi Bej, Gabriele Mayr, Hila Emmert, Dora Stölzl, Sascha Gerdes, Eun Suk Jung, Frauke Degenhardt, Matthias Hübenthal, Eva Ellinghaus, Jan Christian Kässens, Lars Wienbrandt, Wolfgang Lieb, Martina Müller-Nurasyid, Melanie Hotze, Nick Dand, Sarah Grosche, Ingo Marenholz, Andreas Arnold, Georg Homuth, Carsten O. Schmidt, Ul
Published in: Journal of Allergy and Clinical Immunology, Issue 145/4, 2020, Page(s) 1208-1218, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2019.10.030

Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses

Author(s): Lam C. Tsoi, Elke Rodriguez, Dora Stölzl, Ulrike Wehkamp, Jingru Sun, Sascha Gerdes, Mrinal K. Sarkar, Matthias Hübenthal, Chang Zeng, Ranjitha Uppala, Xianying Xing, Frederieke Thielking, Allison C. Billi, William R. Swindell, Alanna Shefler, Jiahan Chen, Matthew T. Patrick, Paul W. Harms, J. Michelle Kahlenberg, Bethany E. Perez White, Emanual Maverakis, Johann E. Gudjonsson, Stephan Weidinger
Published in: Journal of Allergy and Clinical Immunology, Issue 145/5, 2020, Page(s) 1406-1415, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2019.11.047

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis

Author(s): Michael Koch, Tobias Kockmann, Elke Rodriguez, Ulrike Wehkamp, Paul Hiebert, Maya Ben-Yehuda Greenwald, Dora Stölzl, Hans-Dietmar Beer, Erwin Tschachler, Stephan Weidinger, Sabine Werner, Ulrich auf dem Keller
Published in: Journal of Investigative Dermatology, 2022, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2022.08.048

Differences in clinical features and comorbid burden between HLA-C*06:02 carrier groups in 9,000 psoriasis patients

Author(s): Konstantinos Douroudis, Ravi Ramessur, Ines A. Barbosa, David Baudry, Michael Duckworth, Caroline Angit, Francesca Capon, Raymond Chung, Charles J. Curtis, Paola Di Meglio, Jonathan MR. Goulding, Christopher EM. Griffiths, Sang Hyuck Lee, Satveer K. Mahil, Richard Parslew, Nick J. Reynolds, Alexa R. Shipman, Richard B. Warren, Zenas ZN. Yiu, BADBIR Study Group, BSTOP Study Group, Michael A. Simpso
Published in: Journal of Investigative Dermatology, 2021, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2021.08.446

Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models

Author(s): Gijs Rikken, Luca D. Meesters, Patrick A. M. Jansen, Diana Rodijk-Olthuis, Ivonne M. J. J. van Vlijmen-Willems, Hanna Niehues, Jos P. H. Smits, Peter Oláh, Bernhard Homey, Joost Schalkwijk, Patrick L. J. M. Zeeuwen & Ellen H. van den Bogaard
Published in: Microbiome, 2023, ISSN 2049-2618
Publisher: BioMed Central
DOI: 10.1186/s40168-023-01668-x

COPS: A novel platform for multi-omic disease subtype discovery via robust multi-objective evaluation of clustering algorithms

Author(s): Teemu J. Rintala, Vittorio Fortino
Published in: PLOS Computational Biology, Issue 20, 2024, Page(s) e1012275, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012275

miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar

Author(s): Gemma Carreras-Badosa, Julia Maslovskaja, Helen Vaher, Laura Pajusaar, Tarmo Annilo, Freddy Lättekivi, Matthias Hübenthal, Elke Rodriguez, Stephan Weidinger, Külli Kingo & Ana Rebane
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-27235-2

Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis

Author(s): Amy R. Mulick, Alasdair D. Henderson, David Prieto-Merino, Kathryn E. Mansfield, Julian Matthewman, Jennifer K. Quint, Ronan A. Lyons, Aziz Sheikh, David A. McAllister, Dorothea Nitsch & Sinéad M. Langan
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-26357-x

Manually curated and harmonised transcriptomics datasets of psoriasis and atopic dermatitis patients

Author(s): Antonio Federico, Veera Hautanen, Nils Christian, Andreas Kremer, Angela Serra, Dario Greco
Published in: Scientific Data, Issue 7/1, 2020, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1038/s41597-020-00696-8

Microbe-host interplay in atopic dermatitis and psoriasis

Author(s): Nanna Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Hanna Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari Suomela, Ioannis Tessas, Emilia Lybeck, Anna
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12253-y

Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies

Author(s): Jake R. Saklatvala, Ken B. Hanscombe, Satveer K. Mahil, Lam C. Tsoi, James T. Elder, Jonathan N. Barker, Michael A. Simpson, Catherine H. Smith, Nick Dand
Published in: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.02.010

Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis

Author(s): Melina Fonfara, Jan Hartmann, Dora Stölzl, Nicole Sander, Inken Harder, Elke Rodriguez, Matthias Hübenthal, Carsten Mazur, Sebastian Kerzel, Michael Kabesch, Jochen Schmitt, Hila Emmert, Ina Suhrkamp, Stephan Weidinger
Published in: Journal of the European Academy of Dermatology and Venereology (JEADV), 2024, ISSN 0926-9959
Publisher: Elsevier BV
DOI: 10.1111/jdv.19932

Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review

Author(s): Conor Broderick, Stefanie Ziehfreund, Karin van Bart, Bernd Arents, Kilian Eyerich, Stephan Weidinger, Joseph Rastrick, Alexander Zink, Carsten Flohr, BIOMAP Consortium
Published in: Allergy, 2022, ISSN 1398-9995
Publisher: John Wiley and Sons, Ltd
DOI: 10.1111/all.15578

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Author(s): Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, 23andMe Research Team, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Estonian Biobank Research Team, Reedik Mägi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-So
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41180-2

Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis

Author(s): Ravi Ramessur, Jake Saklatvala, Ashley Budu-Aggrey, Marek Ostaszewski, Lena Möbus, Dario Greco, Matladi Ndlovu, Satveer K. Mahil, Jonathan N. Barker, Sara Brown, Lavinia Paternoster, Nick Dand, Michael A. Simpson, Catherine H. Smith
Published in: JAMA Cardiology, Issue 9, 2024, Page(s) 1009, ISSN 2380-6583
Publisher: American Medical Association (AMA)
DOI: 10.1001/jamacardio.2024.2859

Keratinocyte signaling in atopic dermatitis: Investigations in organotypic skin models toward clinical application

Author(s): Luca D. Meesters, Hanna Niehues, Luke Johnston, Jos P. H. Smits, Patrick L. J. M. Zeeuwen, Sara J. Brown and Ellen H. van den Bogaard
Published in: Journal of Allergy and Clinical Immunology, 2023, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.02.012

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