Viral Haemorrhagic Fever: Modern Approaches for developing bedside Rapid Diagnostics

Project Information

VHFMoDRAD

Grant agreement ID: 823666

DOI 10.3030/823666

Project closed

EC signature date 10 December 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 050 012,50

EU contribution € 3 316 012,50

Coordinated by

FOLKHALSOMYNDIGHETEN
Sweden

Deliverables

Demonstrators, pilots, prototypes (4)

Lateral flow assays (LFAs)

Rapid tests for antigen or antibody detection M36 mono or multiplex LFD tests will be manufactured for evaluation in primary care settings andor field laboratory

Optimized 3-LFD strip available in U-star cassette

Optimized 3LFD strip available in Ustar cassette

Monoclonal antibodies

These antibodies will be used in the antigen detection assays ELISA and LFA and as control reagents IgMs

QC-lyoph-P&P for POC use of Flex-C in WP4 and WP5

Production of adequate number of QClyophPP for POC use of FlexC Due M12 18 24 30 36

Publications

Peer reviewed articles (5)

Rapid On-Site Detection of Arboviruses by a Direct RT-qPCR Assay

Author(s): Moufid Mhamadi, Giulia Mencattelli, Alioune Gaye, El Hadji Ndiaye, Aïssatou Aïcha Sow, Martin Faye, Marie Henriette Dior Ndione, Moussa Moïse Diagne, Moundhir Mhamadi, Ousmane Faye, Manfred Weidmann, Oumar Faye, Mawlouth Diallo and Cheikh Tidiane Diagne
Published in: Biosensors, 2023, Page(s) 1035, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios13121035

Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples

Author(s): Boris Pastorino, Franck Touret, Magali Gilles, Lea Luciani, Xavier de Lamballerie, Remi N. Charrel
Published in: Viruses, Issue 12/6, 2020, Page(s) 624, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060624

Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions

Author(s): Laura Pezzi, Remi N. Charrel, Laetitia Ninove, Antoine Nougairede, Gregory Molle, Bruno Coutard, Guillaume Durand, Isabelle Leparc-Goffart, Xavier de Lamballerie, Laurence Thirion
Published in: Viruses, Issue 12/6, 2020, Page(s) 686, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060686

Lyophilized Matrix Containing Ready-to-Use Primers and Probe Solution for Standardization of Real-Time PCR and RT-qPCR Diagnostics in Virology

Author(s): Thirion, Dubot-Peres, Pezzi, Corcostegui, Touinssi, de Lamballerie, Charrel
Published in: Viruses, Issue 12/2, 2020, Page(s) 159, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12020159

Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?

Author(s): Boris Pastorino, Franck Touret, Magali Gilles, Xavier de Lamballerie, Remi N. Charrel
Published in: Viruses, Issue 12/7, 2020, Page(s) 735, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070735