Viral Haemorrhagic Fever: Modern Approaches for developing bedside Rapid Diagnostics

Informations projet

VHFMoDRAD

N° de convention de subvention: 823666

DOI 10.3030/823666

Projet clôturé

Date de signature de la CE 10 Decembre 2018

Date de début 1 Janvier 2019

Date de fin 31 Decembre 2023

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 5 050 012,50

Contribution de l’UE € 3 316 012,50

Coordonné par

FOLKHALSOMYNDIGHETEN
Sweden

Livrables

Demonstrators, pilots, prototypes (4)

Lateral flow assays (LFAs)

Rapid tests for antigen or antibody detection M36 mono or multiplex LFD tests will be manufactured for evaluation in primary care settings andor field laboratory

Optimized 3-LFD strip available in U-star cassette

Optimized 3LFD strip available in Ustar cassette

Monoclonal antibodies

These antibodies will be used in the antigen detection assays ELISA and LFA and as control reagents IgMs

QC-lyoph-P&P for POC use of Flex-C in WP4 and WP5

Production of adequate number of QClyophPP for POC use of FlexC Due M12 18 24 30 36

Publications

Peer reviewed articles (5)

Rapid On-Site Detection of Arboviruses by a Direct RT-qPCR Assay

Auteurs: Moufid Mhamadi, Giulia Mencattelli, Alioune Gaye, El Hadji Ndiaye, Aïssatou Aïcha Sow, Martin Faye, Marie Henriette Dior Ndione, Moussa Moïse Diagne, Moundhir Mhamadi, Ousmane Faye, Manfred Weidmann, Oumar Faye, Mawlouth Diallo and Cheikh Tidiane Diagne
Publié dans: Biosensors, 2023, Page(s) 1035, ISSN 2079-6374
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios13121035

Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples

Auteurs: Boris Pastorino, Franck Touret, Magali Gilles, Lea Luciani, Xavier de Lamballerie, Remi N. Charrel
Publié dans: Viruses, Numéro 12/6, 2020, Page(s) 624, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060624

Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions

Auteurs: Laura Pezzi, Remi N. Charrel, Laetitia Ninove, Antoine Nougairede, Gregory Molle, Bruno Coutard, Guillaume Durand, Isabelle Leparc-Goffart, Xavier de Lamballerie, Laurence Thirion
Publié dans: Viruses, Numéro 12/6, 2020, Page(s) 686, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060686

Lyophilized Matrix Containing Ready-to-Use Primers and Probe Solution for Standardization of Real-Time PCR and RT-qPCR Diagnostics in Virology

Auteurs: Thirion, Dubot-Peres, Pezzi, Corcostegui, Touinssi, de Lamballerie, Charrel
Publié dans: Viruses, Numéro 12/2, 2020, Page(s) 159, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12020159

Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?

Auteurs: Boris Pastorino, Franck Touret, Magali Gilles, Xavier de Lamballerie, Remi N. Charrel
Publié dans: Viruses, Numéro 12/7, 2020, Page(s) 735, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070735