Membrane protein integrated technologies development for drug design

Informations projet

ProMeTeus

N° de convention de subvention: 823780

DOI

10.3030/823780

Projet clôturé

Date de signature de la CE 4 Octobre 2018

Date de début 1 Janvier 2019

Date de fin 31 Decembre 2023

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 464 600,00

Contribution de l’UE

€ 464 600,00

Coordonné par

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Prometeus web site

The website will present the project to the wider public and give detailed, tailored information on, e.g., project progress, activities and results. The website will also contain: 1) a dedicated section for society at large, in which project activities are presented in a language understandable to non-experts; b) a private area – accessible only to partners– for the exchange of working documents. The PMT will be responsible for the creation and updating of the website.

Final Conference

The Final Conference will be open to the public and it will report the scientific and technological results obtained during the Action

Other (1)

Workshop on Membrane proteins

WP6 will include the organization of a 2-day practical multi-disciplinary Workshop on “Membrane proteins: strategies for production, stabilization and structural analysis”.

Publications

Peer reviewed articles (11)

Small-angle scattering from flat bilayers containing correlated scattering length density inhomogeneities

Auteurs: Francesco Spinozzi, Leandro R. S. Barbosa, Giacomo Corucci, Paolo Mariani and Rosangela Itri
Publié dans: Journal of Applied Crystallography, Numéro 2023, 56, 2023, Page(s) 1348-1360, ISSN 1600-5767
Éditeur: International Union of Crystallography
DOI: 10.1107/s1600576723006143

SAXS Reveals the Stabilization Effects of Modified Sugars on Model Proteins

Auteurs: Astra Piccinini, Eva C. Lourenço, Osvaldo S. Ascenso, Maria Rita Ventura, Heinz Amenitsch, Paolo Moretti, Paolo Mariani, Maria Grazia Ortore and Francesco Spinozzi
Publié dans: Life, Numéro 12(1), 15 January 2022, 2022, Page(s) 123, ISSN 2075-1729
Éditeur: MDPI
DOI: 10.3390/life12010123

Small-Angle Neutron Scattering Reveals the Nanostructure of Liposomes with Embedded OprF Porins of Pseudomonas aeruginosa.

Auteurs: Spinozzi F, Alcaraz JP, Ortore MG, Gayet L, Radulescu A, Martin DK, Maccarini M.
Publié dans: Langmuir, 2022, Page(s) 15026-15037, ISSN 1520-5827
Éditeur: American Chemical Society
DOI: 10.1021/acs.langmuir.2c01342

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis

Auteurs: Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17202-8

Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate.

Auteurs: Giacomo Parisi; Giacomo Parisi; Ida Freda; Cécile Exertier; Cristina Cecchetti; Cristina Cecchetti; Elena Gugole; Gabriele Cerutti; Gabriele Cerutti; Lucia D'Auria; Alberto Macone; Beatrice Vallone; C. Savino; Linda Celeste Montemiglio
Publié dans: Biomolecules, Numéro 1, 2022, Page(s) 1411, ISSN 2218-273X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom10101411

High Throughput Expression Screening of Arabinofuranosyltransferases from Mycobacteria

Auteurs: José Rodrigues, Vanessa T. Almeida, Ana L. Rosário, Yong Zi Tan, Brian Kloss, Filippo Mancia, Margarida Archer
Publié dans: Processes, Numéro 9/4, 2021, Page(s) 629, ISSN 2227-9717
Éditeur: MDPI
DOI: 10.3390/pr9040629

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

Auteurs: Linda Celeste Montemiglio, Claudia Testi, Pierpaolo Ceci, Elisabetta Falvo, Martina Pitea, Carmelinda Savino, Alessandro Arcovito, Giovanna Peruzzi, Paola Baiocco, Filippo Mancia, Alberto Boffi, Amédée des Georges, Beatrice Vallone
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-09098-w

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Auteurs: Yong Zi Tan, Lei Zhang, José Rodrigues, Ruixiang Blake Zheng, Sabrina I. Giacometti, Ana L. Rosário, Brian Kloss, Venkata P. Dandey, Hui Wei, Richard Brunton, Ashleigh M. Raczkowski, Diogo Athayde, Maria João Catalão, Madalena Pimentel, Oliver B. Clarke, Todd L. Lowary, Margarida Archer, Michael Niederweis, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publié dans: Molecular Cell, Numéro 78/4, 2020, Page(s) 683-699.e11, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2020.04.014

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

Auteurs: Lucia Silvestrini, Norhan Belhaj, Lucia Comez, Yuri Gerelli, Antonino Lauria, Valeria Libera, Paolo Mariani, Paola Marzullo, Maria Grazia Ortore, Antonio Palumbo Piccionello, Caterina Petrillo, Lucrezia Savini, Alessandro Paciaroni, Francesco Spinozzi
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-88630-9

Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination

Auteurs: Juliana Gonçalves, Margarida Juliano, Nádia Charepe, Marta Alenquer, Diogo Athayde, Filipe Ferreira, Margarida Archer, Maria João Amorim, Fátima Serrano, Helena Soares
Publié dans: Cell Reports Medicine, Numéro Volume 2, Numéro 12, 21 December 2021, 2021, Page(s) 100468, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2021.100468

Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir

Auteurs: Alessandro Paciaroni; Valeria Libera; Francesca Ripanti; Andrea Orecchini; Caterina Petrillo; Daniela Francisci; Elisabetta Schiaroli; Samuele Sabbatini; Anna Gidari; Elisa Bianconi; Antonio Macchiarulo; Rohanah Hussain; Lucia Silvestrini; Paolo Moretti; Norhan Belhaj; Matteo Vercelli; Yessica Roque; Paolo Mariani; Lucia Comez; Francesco Spinozzi
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 6062, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076062