Innovation in Tuberculosis

Project Information

INNOVA4TB

Grant agreement ID: 823854

DOI

10.3030/823854

Project closed

EC signature date 4 October 2018

Start date 1 January 2019

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 1 039 600,00

EU contribution

€ 1 039 600,00

Coordinated by

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (4)

Open access publications about the study of metabolome and exhaled compounds

Open access publications about the study of the urinary metabolome by NMR, blood metabolome by GC/LC-MS, and volatile compounds in exhaled air by FAIMS.

Open access publications about the improvement of TB therapy strategies

Open access publications describing the characterization of macrophage surface target markers, the development of a new anti-TB drug delivery approach based on nanoparticles, and the study of new biomarkers to individualize the therapy duration

Open access publication about the study of primary immunodeficiencies

Publication describing the study of primary immunodeficiencies with Whole Exome Sequencing

Open access publication(s) about the study of the Host-Pathogen interaction

Publications describing the characterization of the immunologic response of CD4 and CD8 Tcells expressing CD27 andor CCR4 surface markers the study of the host immune response against different M tuberculosis antigens by means Luminex and flow cytometry and the transcriptomic approach for a specific blood signature of progression to active TB

Other (1)

Mid-term meeting

Meeting of all the partners in the consortium, with workshops, training, networking, and communication and dissemination activities.

Publications

Peer reviewed articles (17)

Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis

Author(s): Patricia Comella-del-Barrio, Bárbara Molina-Moya, Jacqueline Gautier, Raquel Villar-Hernández, Mariette Jean Coute Doresca, Beatriz Sallés-Mingels, Lydia Canales-Aliaga, Margareth Narcisse, Tomás M. Pérez-Porcuna, Jacob Creswell, Luis E. Cuevas, José Domínguez
Published in: Journal of Clinical Medicine, Issue 10/9, 2021, Page(s) 1914, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10091914

Development and Evaluation of an NTM-IGRA to Guide Pediatric Lymphadenitis Diagnosis

Author(s): Raquel Villar-Hernández, Irene Latorre, Antoni Noguera-Julian, Aina Martínez-Planas, Laura Minguell, Teresa Vallmanya, María Méndez, Antoni Soriano-Arandes, Fernando Baquero-Artigao, Paula Rodríguez-Molino, Sara Guillén-Martín, Carlos Toro-Rueda, M Luiza De Souza-Galvão, M Ángeles Jiménez-Fuentes, Zoran Stojanovic, Josefina Sabriá, José Ramón Santos, Jordi Puig, Marisol Domínguez-Ál
Published in: Pediatric Infectious Disease Journal, Issue 43, 2024, Page(s) 278-285, ISSN 0891-3668
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000004211

Molecular Detection of Mycobacterium tuberculosis in Oral Mucosa from Patients with Presumptive Tuberculosis

Author(s): Barbara Molina-Moya, Nelly Ciobanu, Marta Hernandez, Cristina Prat-Aymerich, Valeriu Crudu, Emily R. Adams, Alexandru Codreanu, Derek J. Sloan, Luis E. Cuevas, Jose Dominguez
Published in: Journal of Clinical Medicine, Issue 9/12, 2020, Page(s) 4124, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9124124

Remote analysis of sputum smears for mycobacterium tuberculosis quantification using digital crowdsourcing

Author(s): Lara García Delgado, María Postigo, Daniel Cuadrado, Sara Gil-Casanova, Álvaro Martínez Martínez, María Linares, Paloma Merino, Manuel Gimo, Silvia Blanco, Quique Bassat, Andrés Santos, Alberto L García-Basteiro, María J Ledesma-Carbayo, Miguel Á Luengo-Oroz
Published in: PLoS One, Issue 19326203, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0268494

Impact of diesel exhaust particles on infections with Mycobacterium bovis BCG in in vitro human macrophages and an in vivo Galleria mellonella model

Author(s): Pablo Rodríguez-Fernández, Iris Romero-Andrada, Bárbara Molina-Moya, Irene Latorre, Alícia Lacoma, Cristina Prat-Aymerich, Lydia Tabernero, José Domínguez
Published in: Environmental Pollution, Issue 341, 2024, Page(s) 122597, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122597

Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management

Author(s): Guillem Safont, Irene Latorre, Raquel Villar-Hernández, Zoran Stojanovic, Alicia Marín, Cristina Pérez-Cano, Alicia Lacoma, Bárbara Molina-Moya, Alan Jhunior Solis, Fernando Arméstar, Joan Matllo, Sergio Díaz-Fernández, Arnau Cendón, Liliya Sokalchuk, Guillermo Tolosa, Irma Casas, Antoni Rosell, José Domínguez
Published in: Journal of Clinical Medicine, Issue 11, 2024, Page(s) 5103, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11175103

Impact of COVID-19 on Tuberculosis Control

Author(s): Patricia Comella-del-Barrio, Maria Luiza De Souza-Galvão, Cristina Prat-Aymerich, José Domínguez
Published in: Archivos de Bronconeumología, 2020, ISSN 0300-2896
Publisher: Ediciones Doyma S.A.
DOI: 10.1016/j.arbres.2020.11.016

Evaluation of Omnigene-Sputum for Preservation of Sputum Samples for Diagnosis of Mycobacterium tuberculosis

Author(s): Edson Mambuque, Belén Saavedra, Barbara Molina-Moya, Dinis Nguenha, Esther García-García, Silvia Blanco, Neide Gomes, Joanna Ehrlich, Helder Bulo, Shilzia Munguambe, Helio Chiconela, Sozinho Acacio, José Domínguez, Alberto L. García-Basteiro
Published in: Tropical Medicine and Infectious Disease, Issue 8, 2023, Page(s) 367, ISSN 2414-6366
Publisher: MDPI
DOI: 10.3390/tropicalmed8070367

Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

Author(s): Bárbara Molina-Moya, Raquel Villar-Hernández, Nelly Ciobanu, Beatriz Muriel-Moreno, Alicia Lacoma, Alexandru Codreanu, Irene Latorre, Daria Smalchuk, Cristina Prat-Aymerich, Valeriu Crudu, Konstantina Kontogianni, Luis E. Cuevas, José Domínguez
Published in: Frontiers in Tuberculosis, Issue 1, 2023, ISSN 2813-7868
Publisher: Frontiers
DOI: 10.3389/ftubr.2023.1267221

Fujifilm SILVAMP TB-LAM for the Diagnosis of Tuberculosis in Nigerian Adults

Author(s): Patricia Comella-del-Barrio, John S. Bimba, Ramota Adelakun, Konstantina Kontogianni, Bárbara Molina-Moya, Okoedoh Osazuwa, Jacob Creswell, Luis E. Cuevas, José Domínguez
Published in: Journal of Clinical Medicine, Issue 10/11, 2021, Page(s) 2514, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10112514

Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment

Author(s): Sergio Díaz-Fernández, Raquel Villar-Hernández, Zoran Stojanovic, Marco Fernández, Maria Luiza De Souza Galvão, Guillermo Tolosa, Adrián Sánchez-Montalva, Jorge Abad, María Ángeles Jiménez-Fuentes, Guillem Safont, Iris Romero, Josefina Sabrià, Cristina Prat, Jose Domínguez, Irene Latorre
Published in: Frontiers in Microbiology, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.885312

Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement

Author(s): José Domínguez, Martin J Boeree, Emmanuelle Cambau, Dumitru Chesov, Francesca Conradie, Vivian Cox, Keertan Dheda, Andrii Dudnyk, Maha R Farhat, Sebastien Gagneux, Martin P Grobusch, Matthias I Gröschel, Lorenzo Guglielmetti, Irina Kontsevaya, Berit Lange, Frank van Leth, Christian Lienhardt, Anna M Mandalakas, Florian P Maurer, Matthias Merker, Paolo Miotto, Barbara Molina-Moya, Florence Morel
Published in: The Lancet Infectious Diseases, Issue 23, 2023, Page(s) e122-e137, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00875-1

Impact of line probe assay-based molecular testing on individualized treatment in patients with rifampicin-resistant tuberculosis: data from the prospective INNOVA4TB cohort study in Ukraine

Author(s): Andrii Dudnyk, Matthias Hempel, Oksana Lytvyniuk, Halyna Liudkevych, Volodymyr Matsera, Tetiana Nikitchenko, Svitlana Blyzniuk, Barbara Molina-Moya, Rosemarie Preyer, José Domínguez
Published in: Therapeutic Advances in Respiratory Disease, Issue 18, 2024, ISSN 1753-4666
Publisher: Sage Journals
DOI: 10.1177/17534666241249841

Advances in diagnostic tools for respiratory tract infections: from tuberculosis to COVID-19 – changing paradigms?

Author(s): Zoran Stojanovic, Filipe Gonçalves-Carvalho, Alicia Marín, Jorge Abad Capa, Jose Domínguez, Irene Latorre, Alicia Lacoma, Cristina Prat-Aymerich
Published in: ERJ Open Research, Issue 8, 2023, Page(s) 00113-2022, ISSN 2312-0541
Publisher: European Respiratory Society
DOI: 10.1183/23120541.00113-2022

Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection

Author(s): Anna A. Starshinova, Igor Kudryavtsev, Anna Malkova, Ulia Zinchenko, Vadim Karev, Dmitry Kudlay, Angela Glushkova, Anastasiya Y. Starshinova, Jose Dominguez, Raquel Villar-Hernández, Irina Dovgalyk, Piotr Yablonskiy
Published in: International Journal of Molecular Sciences, Issue 23, 2024, Page(s) 2235, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042235

MptpB Inhibitor Improves the Action of Antibiotics against <i>Mycobacterium tuberculosis</i> and Nontuberculous <i>Mycobacterium avium</i> Infections

Author(s): Pablo Rodríguez-Fernández, Laure Botella, Jennifer S. Cavet, Jose Domínguez, Maximiliano G. Gutierrez, Colin J. Suckling, Fraser J. Scott, Lydia Tabernero
Published in: ACS Infectious Diseases, Issue 10, 2024, Page(s) 170-183, ISSN 2373-8227
Publisher: ACS publications
DOI: 10.1021/acsinfecdis.3c00446

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Author(s): Patricia Comella-del-Barrio, José Luis Izquierdo-Garcia, Jacqueline Gautier, Mariette Jean Coute Doresca, Ramón Campos-Olivas, Clara M. Santiveri, Beatriz Muriel-Moreno, Cristina Prat-Aymerich, Rosa Abellana, Tomas M. Pérez-Porcuna, Luis E. Cuevas, Jesús Ruiz-Cabello, José Domínguez
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-91545-0