Project description
Figuring out what proteins are trying to tell us when they repeat themselves
Proteins are the building blocks of organisms, the blueprint for which is stored in genetic material. More than 10 % of all proteins and more than a third of human proteins contain arrays of tandem repeats, short sequences from a single amino acid to 100 or more residues that are repeated anywhere from a few to hundreds of times. Protein tandem repeats (PTR) are often associated with disease. With the support of the Marie Skłodowska-Curie Actions programme, the REFRACT project has formed an international consortium of experts in PTR and associated methodologies to push the frontiers of PTR characterisation.
Objective
The REFRACT proposal answers the RISE call, aiming at the promotion of an international and interdisciplinary collaboration on tandem repeat proteins (TRPs) through the sharing of knowledge and expertise between partners via staff exchanges. REFRACT is an international consortium aiming to extend our knowledge on the mechanism of TRP function and evolution, establishing a common classification and best practices. Starting from available state of the art computational tools and databases, which have been mostly developed by REFRACT participants, it aims drive a new level of TRP characterization leveraging the complementary expertise of 7 EU MS and 9 TC institutions in Latin America, with the latter providing useful complementary expertises. This aim will be achieved by the following steps:
Benchmarking different existing methods and defining their use-cases;
Coordinating the necessary next steps to analyze TRP roles in biological pathways and organism evolution;
Providing a detailed description of their mechanism of function, related to their structural properties, that can be of great importance in TRP-related medical research and biotechnological applications;
Building a unified and commonly accepted TRP classification from sequence and structure as well as characterizing the relationship between the two.
The REFRACT implementation will take advantage of the different expertises, supporting them by a combination of research-centered, training and dissemination activities. The secondment program is designed so that all the participating institutions will be actively involved not only in the production of scientific outcomes, but also be empowered with the responsibility of planning, monitoring and discussing project advancement. The broadest possible dissemination of the results will be achieved through dedicated activities, the propagation of results into ELIXIR core data resources (InterPro, and consequently UniProt) as well as possible industrial exploitation.
Fields of science
Programme(s)
Coordinator
35122 Padova
Italy