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Repeat protein Function Refinement, Annotation and Classification of Topologies

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Collection of TRP datasets.

Collection of TRP datasets

Report on the state-of-the-art of TRP-related HMMs and TRP covariance analysis.
Report on the function of new TRP families.

Report on the function of new TRP families

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures.

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures

Report on mapping and analysis of exon boundaries on TRPs, comparison with their modularity, and TRP amino acid vs DNA sequence variability.

Report on mapping and analysis of exon boundaries on TRPs comparison with their modularity and TRP amino acid vs DNA sequence variability

Symposia/Remote Symposia Period 2

Symposia Period 2. Europe: 2 x All-Hands Meeting, 1 x Dissemination Training School, 1 x Final Dissemination meeting. Latin America: 2 x Annual Latin America Visit.

TRP function, localization and organism distribution enrichment analysis.

TRP function localization and organism distribution enrichment analysis

Symposia/Remote Symposia Period 1

Symposia Period 1 Europe 2 x AllHands Meeting 1 x Dissemination Training School Latin America 2 x Annual Latin America Visit

Report about TRP roles in PPI networks and interaction with RNA/DNA molecules and role of TRPs in host interactions with viruses and pathogens.

Report about TRP roles in PPI networks and interaction with RNADNA molecules and role of TRPs in host interactions with viruses and pathogens

Report on TRP disorder, low-complexity, transmembrane domain overlap and examples of cooperative TRP folding.

Report on TRP disorder lowcomplexity transmembrane domain overlap and examples of cooperative TRP folding

Report on TRP sequence and structural classification as well as sequence and structural clustering of the TRP universe.
Cookbook for TRP annotation best-practices. Report about data format gold-standard, technical and implementation best-practices for TRP web resources.

Cookbook for TRP annotation bestpractices Report about data format goldstandard technical and implementation bestpractices for TRP web resources

Report on SLIMs in TRPs.

Report on SLIMs in TRPs

Publications

The Feature-Viewer: a visualization tool for positional annotations on a sequence

Author(s): Lisanna Paladin; Mathieu Schaeffer; Pascale Gaudet; Monique Zahn-Zabal; Pierre-André Michel; Damiano Piovesan; Silvio C. E. Tosatto; Amos Marc Bairoch
Published in: Bioinformatics, Issue 8, 2020, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btaa055

RING-PyMOL: residue interaction networks of structural ensembles and molecular dynamics

Author(s): Del Conte A.; Monzon A. M.; Clementel D.; Camagni G. F.; Minervini G.; Tosatto S. C. E.; Piovesan D.
Published in: Bioinformatics, Issue 16, 2023, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btad260

Prokaryotic membrane coat - like proteins: An update

Author(s): M. Leticia Ferrelli; Matías L. Pidre; Ruben García-Domínguez; Lucas N. Alberca; DMaría del Saz-Navarro; Carlos Santana-Molina; Damien P. Devos
Published in: Journal of Structural Biology, Issue 8, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.107987

ProSeqViewer: an interactive, responsive and efficient TypeScript library for visualization of sequences and alignments in web applications

Author(s): Martina Bevilacqua, Lisanna Paladin, Silvio C E Tosatto, Damiano Piovesan
Published in: Bioinformatics, 2021, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btab764

A New Census of Protein Tandem Repeats and Their Relationship with Intrinsic Disorder

Author(s): Matteo Delucchi, Elke Schaper, Oxana Sachenkova, Arne Elofsson and Maria Anisimova
Published in: Genes, 2020, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11040407

The sequence context in poly-alanine regions: structure, function and conservation

Author(s): Pablo Mier, Carlos A Elena-Real, Juan Cortés, Pau Bernadó, Miguel A Andrade-Navarro
Published in: Bioinformatics, 2022, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btac610

The nucleotide landscape of polyXY regions

Author(s): Pablo Mier, Miguel A. Andrade-Navarro
Published in: Computational and Structural Biotechnology Journal, Issue 21, 2024, Page(s) 5408-5412, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2023.10.054

"""Protein"" no longer means what it used to."

Author(s): Gustavo Parisi; Nicolas Palopoli; Silvio C. E. Tosatto; María Silvina Fornasari; Peter Tompa
Published in: Current Research in Structural Biology, Issue 8, 2021, ISSN 2665-928X
Publisher: Elsevier
DOI: 10.1016/j.crstbi.2021.06.002

WebSTR: A Population-wide Database of Short Tandem Repeat Variation in Humans

Author(s): Lundström OS, Adriaan Verbiest M, Xia F, Jam HZ, Zlobec I, Anisimova M, Gymrek M
Published in: Journal of Molecular Biology, 2023, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2023.168260

DOME: recommendations for supervised machine learning validation in biology

Author(s): Ian Walsh, Dmytro Fishman, Dario Garcia-Gasulla, Tiina Titma, Gianluca Pollastri, ELIXIR Machine Learning Focus Group, Jennifer Harrow, Fotis E. Psomopoulos & Silvio C. E. Tosatto
Published in: Nature Methods, 2021, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01205-4

Experimentally determined long intrinsically disordered protein regions are now abundant in the Protein Data Bank

Author(s): Alexander Miguel Monzon; Marco Necci; Federica Quaglia; Ian Walsh; Giuseppe Zanotti; Damiano Piovesan; Silvio C. E. Tosatto
Published in: International Journal of Molecular Sciences, Issue 8, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2020.02.17.952028

Census of exposed aggregation-prone regions in proteomes

Author(s): Théo Falgarone, Etienne Villain, Francois Richard, Zarifa Osmanli, Andrey V Kajava
Published in: Briefings in Bioinformatics, 2023, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbad183

The repetitive structure of DNA clamps: An overlooked protein tandem repeat

Author(s): Arrías PN, Monzon AM, Clementel D, Mozaffari S, Piovesan D, Kajava AV, Tosatto SCE
Published in: Journal of Structural Biology, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.108001

RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles

Author(s): Damiano Clementel, Alessio Del Conte, Alexander Miguel Monzon, Giorgia F Camagni, Giovanni Minervini, Damiano Piovesan, Silvio C E Tosatto
Published in: Nucleic Acids Research, 2022, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac365

Daisy: An integrated repeat protein curation service

Author(s): Manuel, Bezerra-Brandao; Ronaldo Romario, Tunque Cahui; Layla, Hirsh
Published in: Journal of Structural Biology, Issue 6, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.108033

Structured Tandem Repeats in Protein Interactions

Author(s): Mac Donagh J, Marchesini A, Spiga A, Fallico MJ, Arrías PN, Monzon AM, Vagiona AC, Gonçalves-Kulik M, Mier P, Andrade-Navarro MA
Published in: International Journal of Molecular Sciences, 2024, ISSN 1661-6596
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/ijms25052994

CAFA-evaluator: A Python Tool for Benchmarking Ontological Classification Methods

Author(s): Piovesan, Damiano; Zago, Davide; Joshi, Parnal; Kaluza, M. Clara De Paolis; Monzon, Alexander Miguel; Reade, Walter; Friedberg, Iddo; Radivojac, Predrag; Tosatto, Silvio C. E.
Published in: Bioinformatics Advances, Issue 16, 2024, ISSN 2635-0041
Publisher: Oxford University Press
DOI: 10.1093/bioadv/vbae043

Structure-function relationships in protein homorepeats

Author(s): Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernadó P.
Published in: Current Opinion in Structural Biology, 2023, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2023.102726

Protein repeats evolve and emerge in giant viruses

Author(s): Erdozain Bagolin, Sofía Agostina; Barrionuevo, Emilia Mercedes; Ripoll, Lucas; Mier, Pablo; Andrade Navarro, Miguel A.
Published in: Journal of Structural Biology, Issue 11, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.107962

Tally-2.0: upgraded validator of tandem repeat detection in protein sequences.

Author(s): Vladimir Perovic; Jeremy Y Leclercq; Neven Sumonja; Francois Richard; Francois Richard; Nevena Veljkovic; Andrey V. Kajava
Published in: Bioinformatics, Issue 8, 2020, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btaa121

Combining Protein Conformational Diversity and Phylogenetic Information Using CoDNaS and CoDNaS-Q

Author(s): Escobedo N, Monzon AM, Fornasari MS, Palopoli N, Parisi G
Published in: Current Protocols, 2023, ISSN 2691-1299
Publisher: John Wiley & Sons
DOI: 10.1002/cpz1.764

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures.

Author(s): Lisanna Paladin; Martina Bevilacqua; Sara Errigo; Damiano Piovesan; Ivan Mičetić; Marco Necci; Alexander Miguel Monzon; María Laura Fabre; José Luis López; Juliet F. Nilsson; Javier Rios; Pablo Lorenzano Menna; Maia Diana Eliana Cabrera; Martin Gonzalez Buitron; Mariane Gonçalves Kulik; Sebastian Fernandez-Alberti; María Silvina Fornasari; Gustavo Parisi; Antonio Lagares; Layla Hirsh; Migue
Published in: Nucleic Acids Research, Issue 4, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1097

Why does the first protein repeat often become the only one?

Author(s): Manasra S, Kajava AV
Published in: Journal of Structural Biology, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.108014

Critical assessment of protein intrinsic disorder prediction (<scp>CAID</scp>) ‐ Results of round 2

Author(s): Del Conte A.; Mehdiabadi M.; Bouhraoua A.; Monzon A. M.; Tosatto S. C. E.; Piovesan D.
Published in: Proteins: Structure, Function and Bioinformatics, Issue 15, 2023, ISSN 0887-3585
Publisher: Wiley-Liss Inc
DOI: 10.1002/prot.26582

Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families

Author(s): Claudio Bassot, Arne Elofsson
Published in: PLOS Computational Biology, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1008798

Expanding the repertoire of human tandem repeat RNA-binding proteins

Author(s): Agustín Ormazábal; Matías Sebastián Carletti; Tadeo Enrique Saldaño; Martín Gonzalez-Buitron; Julia Marchetti; Nicolas Palopoli; Alex Bateman
Published in: PLoS ONE, Issue 11, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0290890

A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication

Author(s): Lisanna Paladin, Marco Necci, Damiano Piovesan, Pablo Mier, Miguel A.Andrade-Navarro, Silvio C.E.Tosatto
Published in: Journal of Structural Biology, 2022, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2020.107608

Short tandem repeat mutations regulate gene expression in colorectal cancer

Author(s): Max A. Verbiest; Oxana Lundström; Feifei Xia; Michael Baudis; Tugce Bilgin Sonay; Maria Anisimova
Published in: Scientific Reports, Issue 18, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1101/2023.11.29.569189

Beyond Microsatellite Instability: Intrinsic Disorder as a Potential Link Between Protein Short Tandem Repeats and Cancer

Author(s): Max A. Verbiest, Matteo Delucchi, Tugce Bilgin Sonay and Maria Anisimova
Published in: Frontiers in Bioinformatics, 2021, ISSN 2673-7647
Publisher: Frontiers Media
DOI: 10.3389/fbinf.2021.685844

APICURON: a database to credit and acknowledge the work of biocurators

Author(s): András Hatos, Federica Quaglia, Damiano Piovesan, Silvio C E Tosatto
Published in: Database, 2021, ISSN 1758-0463
Publisher: Oxford University Press
DOI: 10.1093/database/baab019

CAID prediction portal: A comprehensive service for predicting intrinsic disorder and binding regions in proteins

Author(s): Alessio Del Conte, Adel Bouhraoua, Mahta Mehdiabadi, Damiano Clementel, Alexander Miguel Monzon, CAID predictors , Silvio C E Tosatto, Damiano Piovesan
Published in: Nucleic Acids Research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad430

The features of polyglutamine regions depend on their evolutionary stability

Author(s): Pablo Mier, Miguel A. Andrade-Navarro
Published in: BMC Ecology and Evolution, 2020, ISSN 2730-7182
Publisher: Springer Nature
DOI: 10.1186/s12862-020-01626-3

The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis

Author(s): Osmanli, Z.; Falgarone, T.; Samadova, T.; Aldrian, G.; Leclercq, J.; Shahmuradov, I.; Kajava, A.V.
Published in: Biomolecules, 2022, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biom12111610

REP2: A Web Server to Detect Common Tandem Repeats in Protein Sequences

Author(s): Mohamed Kamel, Kristina Kastano, Pablo Mier, Miguel A. Andrade
Published in: Journal of Molecular Biology, 2021, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.166895

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

Author(s): Hamidreza Ghafouri; Tamas Lazar; Alessio Del Conte; Luiggi G Tenorio Ku; Maria C Aspromonte; Pau Bernadó; Belén Chaves-Arquero; Lucia Beatriz Chemes; Damiano Clementel; Tiago N Cordeiro; Carlos A Elena-Real; Michael Feig; Isabella C Felli; Carlo Ferrari; Julie D Forman-Kay; Tiago Gomes; Frank Gondelaud; Claudiu C Gradinaru; Tâp Ha-Duong; Teresa Head-Gordon; Pétur O Heidarsson; Giacomo Janson
Published in: Nucleic Acids Research, Issue 16, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad947

TRAL 2.0 : tandem repeat detection with circular profile hidden Markov models and evolutionary aligner

Author(s): Matteo Delucchi; Paulina Näf; Spencer Bliven; Maria Anisimova
Published in: Frontiers in Bioinformatics, Issue 5, 2021, ISSN 2673-7647
Publisher: Frontiers Media
DOI: 10.21256/zhaw-22764

Pfam: The protein families database in 2021.

Author(s): Jaina Mistry; Sara Chuguransky; Lowri Williams; Matloob Qureshi; Gustavo A. Salazar; Erik L. L. Sonnhammer; Silvio C. E. Tosatto; Lisanna Paladin; Shriya Raj; Lorna Richardson; Robert D. Finn; Alex Bateman
Published in: Nucleic Acids Research, Issue 5, 2020, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa913

A STRP-ed definition of Structured Tandem Repeats in Proteins

Author(s): Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade-Navarro, Miguel A; Bevilacqua, Martina; Clementel, Damiano; Bateman, Alex; Hirsh, Layla; Fornasari, Maria Silvina; Parisi, Gustavo; Piovesan, Damiano; Kajava, Andrey V; Tosatto, Silvio C E
Published in: Journal of Structural Biology, Issue 5, 2023, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2023.108023

DisProt in 2024: improving function annotation of intrinsically disordered proteins

Author(s): Maria Cristina Aspromonte; Maria Victoria Nugnes; Federica Quaglia; Adel Bouharoua; Vasileios Sagris; Vasilis J Promponas; Anastasia Chasapi; Erzsébet Fichó; Galo E Balatti; Gustavo Parisi; Martín González Buitrón; Gabor Erdos; Matyas Pajkos; Zsuzsanna Dosztányi; Laszlo Dobson; Alessio Del Conte; Damiano Clementel; Edoardo Salladini; Emanuela Leonardi; Fatemeh Kordevani; Hamidreza Ghafouri;
Published in: Nucleic Acids Research, Issue 18, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad928

PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins.

Author(s): Patryk Jarnot; Joanna Ziemska-Legiecka; László Dobson; Matthew Merski; Pablo Mier; Miguel A. Andrade-Navarro; John M. Hancock; Zsuzsanna Dosztányi; Lisanna Paladin; Marco Necci; Damiano Piovesan; Silvio C. E. Tosatto; Vasilis J. Promponas; Marcin Grynberg; Aleksandra Gruca
Published in: Nucleic Acids Research, Issue 7, 2020, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa339

Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species

Author(s): Max Verbiest; Mikhail Maksimov; Ye Jin; Maria Anisimova; Melissa Gymrek; Tugce Bilgin Sonay
Published in: Journal of Evolutionary Biology, Issue 18, 2023, ISSN 1010-061X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jeb.14106

14th Annual Biocuration Conference (virtual) - Abstracts from the invited speakers talks and poster session presentations

Author(s): Federica Quaglia
Published in: Abstract booklet of the 14th Annual Biocuration Conference (virtual), including invited speakers talks and poster session presentations, 2021
Publisher: Zenodo
DOI: 10.5281/zenodo.5570276

CoDNaS-Q: a database of conformational diversity of the native state of proteins with quaternary structure

Author(s): Nahuel Escobedo, Ronaldo Romario Tunque Cahui, Gastón Caruso, Emilio García Ríos, Layla Hirsh, Alexander Miguel Monzon, Gustavo Parisi, VNicolas Palopoli
Published in: bioRxiv, 2022, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2022.02.15.480082

Conference report: Biocuration 2021 Virtual Conference

Author(s): Federica Quaglia, Rama Balakrishnan, Susan M Bello, Nicole Vasilevsky
Published in: Database, 2022, ISSN 1758-0463
Publisher: Oxford University Press
DOI: 10.1093/database/baac027

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