Deliverables
report on TB mass screening activities in vulnerable, highly endemic populations
TB epidemiology reportWith the results from WP 4 and the mass screening report an in-depth analysis can be made from TB epidemiology in the penal institutions in Paraguay and measures may be discussed and prepared to decline the high TB incidence rates.
Systematic review and reportSystematic review and meta-analysis report of the in vivo and human experience of high dose rifampicin in DS-TB
Correlation reportReport on correlation of genetic polymorphisms, PK, treatment outcome in a mixed Paraguayan cohort and hard to treat patients from Europe and Latin America
Health care cost questionnaireHigh dose rifampicin in vulnerable population report
Phase III Clinical trial protocolwe will review data regarding anti-TB drugs and make a reasoned decision about the best combination therapy to achieve a successful TB treatment outcome in a 4-month treatment duration. A study protocol, adapted to the circumstances present in Latin America and Europe, keeping all the international standards to ensure a high quality trial, will be designed. This design will especially prioritize low cost and simplicity compared to other aspects.
MGM staff from the consortium will provide a workshop on internationalising research at the INORMS conference 2020
external workshop pharmacogeneticsA workshop pharmacogenetic differences between Africans, Latin Americans and European TB patients will be given (at a conference)
Publications
Author(s):
Samiksha Ghimire; Gladys Molinas; Arturo Battaglia; Nilza Martinez; Luis Gómez Paciello; Sarita Aguirre; Jan-Willem C. Alffenaar; Marieke G. G. Sturkenboom; Cecile Magis-Escurra
Published in:
Crossref, Issue 1, 2023, ISSN 1999-4923
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/pharmaceutics15041089
Author(s):
Juan Espinosa-Pereiro; Samiksha Ghimire; Marieke G. G. Sturkenboom; Jan-Willem C. Alffenaar; Margarida Tavares; Sarita Aguirre; Arturo Battaglia; Gladys Molinas; Teresa Tórtola; Onno W. Akkerman; Adrian Sanchez-Montalva; Cecile Magis-Escurra
Published in:
Crossref, Issue 1, 2022, ISSN 1999-4923
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/pharmaceutics15010009
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