European-Latin American TB Research Collaboration Network

Informations projet

EUSAT-RCS

N° de convention de subvention: 823890

DOI

10.3030/823890

Projet clôturé

Date de signature de la CE 26 Octobre 2018

Date de début 1 Avril 2019

Date de fin 31 Mars 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 910 800,00

Contribution de l’UE

€ 910 800,00

Coordonné par

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

TB screening report

report on TB mass screening activities in vulnerable, highly endemic populations

TB epidemiology report

With the results from WP 4 and the mass screening report an in-depth analysis can be made from TB epidemiology in the penal institutions in Paraguay and measures may be discussed and prepared to decline the high TB incidence rates.

Systematic review and report

Systematic review and meta-analysis report of the in vivo and human experience of high dose rifampicin in DS-TB

Correlation report

Report on correlation of genetic polymorphisms, PK, treatment outcome in a mixed Paraguayan cohort and hard to treat patients from Europe and Latin America

Health care cost questionnaire

High dose rifampicin in vulnerable population report

Phase III Clinical trial protocol

we will review data regarding anti-TB drugs and make a reasoned decision about the best combination therapy to achieve a successful TB treatment outcome in a 4-month treatment duration. A study protocol, adapted to the circumstances present in Latin America and Europe, keeping all the international standards to ensure a high quality trial, will be designed. This design will especially prioritize low cost and simplicity compared to other aspects.

Other (2)

MGM workshop at INORMS conference

MGM staff from the consortium will provide a workshop on internationalising research at the INORMS conference 2020

external workshop pharmacogenetics

A workshop pharmacogenetic differences between Africans, Latin Americans and European TB patients will be given (at a conference)

Publications

Peer reviewed articles (2)

Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study

Auteurs: Samiksha Ghimire; Gladys Molinas; Arturo Battaglia; Nilza Martinez; Luis Gómez Paciello; Sarita Aguirre; Jan-Willem C. Alffenaar; Marieke G. G. Sturkenboom; Cecile Magis-Escurra
Publié dans: Crossref, Numéro 1, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041089

Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial

Auteurs: Juan Espinosa-Pereiro; Samiksha Ghimire; Marieke G. G. Sturkenboom; Jan-Willem C. Alffenaar; Margarida Tavares; Sarita Aguirre; Arturo Battaglia; Gladys Molinas; Teresa Tórtola; Onno W. Akkerman; Adrian Sanchez-Montalva; Cecile Magis-Escurra
Publié dans: Crossref, Numéro 1, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010009