Description du projet
Développement d’outils de diagnostic à faible coût pour la détection précoce du cancer du foie
Le carcinome hépatocellulaire (CHC) est le type de cancer du foie le plus courant, principalement associé aux personnes souffrant de maladies du foie de longue durée et à celles dont le foie garde les marques d’une infection par l’hépatite B ou C. La charge élevée du CHC dans les pays en développement constitue un défi majeur de santé publique. Le pronostic des patients atteints de CHC est très défavorable, et un diagnostic précoce s’avère déterminant pour l’issue de la maladie. Financé par le programme Actions Marie Skłodowska-Curie, le projet COCLICAN a pour objet de développer des méthodes efficaces et peu coûteuses de diagnostic précoce, qui pourront être utilisées par les institutions médicales et les patients dans les pays en développement. L’équipe internationale analysera les profils métabolomiques de patients infectés par l’hépatite afin d’identifier les molécules annonciatrices de l’émergence du cancer du foie.
Objectif
Hepatitis B (HBV) and C virus (HCV) are the most important etiologic agents of Hepatocellular carcinoma (HCC), which is the second leading cause of tumour related death in the world. The burden of HCC in developing countries represents a major challenge in global public health for the oncoming decades. Clinically, HCC patients have a very poor prognosis and high 5-year mortality rate except when detected early. As a result, HCC early detection is a critical parameter to anticipate the initiation of a tumour process, but affordable and discriminant diagnostic tools are lacking.
A consortium of European and Third Countries institutions (Peru and Laos) gathered within the project COCLICAN proposes to tackle this issue through the analysis of metabolomics serum profiles of a large cohort of HBV-HBC infected patients to delineate a bunch of molecules predictive of the emergence of liver cancer. The performance of a low-cost and open-source echo-stethoscope connected to a smartphone will also be assessed, to allow early detection of tumorogenesis in health care underserved areas.
This will be possible, thanks to the construction of a sustainable scientific and academic network of engineers, researchers and clinicians mobilised to exchange expertise, skills, technologies, biological material, deployed in three continents: Europe, South America and Asia.
COCLICAN has been designed to improve research collaborations, to reinforce capacities, to enhance knowledge of partners and students involved in the project, but also to raise awareness of policy makers and to participate to the innovation potential improvement at the European and global levels. COCLICAN will therefore respond to the health needs of left behind populations, all around the world.
Champ scientifique
- medical and health scienceshealth sciencespublic health
- medical and health sciencesclinical medicineoncologyliver cancer
- medical and health scienceshealth sciencesinfectious diseasesDNA viruseshepatitis B
- medical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis C
- engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsmobile phones
Programme(s)
Régime de financement
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinateur
13572 Marseille
France