Skip to main content

Green Enantioselective Halogenation for Drug Discovery and Manufacture

Objective

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop and exemplify the use of new catalysts and new green reactions to manufacture important halogenated compounds that could be used in drug discovery and drug production.
In order to achieve this objective the proposal brings together 3 partners with complementary skills:
University of Naples (UNINA): expertise in medicinal chemistry and drug discovery.
KelAda Pharmachem: expertise in green chemistry, chemical batch process development and scale-up.
UCO: expertise in process engineering of continuous flow processes.
We have broken this proposal into the following separate technical Work Packages:

WP1: Preparation of new catalysts for efficient desymmetrization [WP Leader: UNINA].

WP2: Development of enantiospecific halogenation including Fluorination. [WP Leader: Kelada Pharmachem].

WP3 Drug Candidate, library creation & in vitro testing. [WP Leader: Kelada Pharmachem]

WP4 Development of flow variant and scale-up.[WP Leader: UCO}

The above WP's will be undertaken via a series of interlinked secondment of researchers between the consortium partners and will be complemented by a series of training and other initiatives to facilitate interdisciplinary and inter-sectoral knowledge sharing and exchange.

Field of science

  • /medical and health sciences/basic medicine/medicinal chemistry

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Address
Corso Umberto I, 40
80138 Napoli
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 110 400

Participants (2)

KELADA PHARMACHEM LIMITED
Ireland
EU contribution
€ 220 800
Address
21 Obelisk Rise
A94 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD DE CORDOBA
Spain
EU contribution
€ 276 000
Address
Avenida De Medina Azahara 5
14005 Cordoba
Activity type
Higher or Secondary Education Establishments