Single molecule bio-electronic smart system array for clinical testing

Deliverables

Documents, reports (4)

Preliminary report on dissemination, communications and exploitation activities

Preliminary report on dissemination, communications and exploitation activities

SiMBiT Leaflet and Poster

The dissemination activities will be supported by the production of leaflets and posters

Administrative, Financial and Technical Periodic Progress Reports

Administrative, Financial and Technical Periodic Progress Reports

Public Website and Social Media profile Setup

Report on the public Website and Social Media profile Setup

Publications

Peer reviewed articles (18)

Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum

Author(s): Eleonora Macchia, Lucia Sarcina, Caroline Driescher, Zahra Gounani, Amit Tewari, Ronald Osterbacka, Gerardo Palazzo, Angelo Tricase, Zsolt Miklos Kovacs Vajna, Fabrizio Viola, Francesco Modena, Mario Caironi, Fabrizio Torricelli, Irene Esposito, Luisa Torsi
Published in: Advanced Electronic Materials, 2021, Page(s) 2100304, ISSN 2199-160X
Publisher: ?
DOI: 10.1002/aelm.202100304

Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer

Author(s): Caroline Driescher, Katharina Fuchs, Lena Haeberle, Wolfgang Goering, Lisa Frohn, Friederike V. Opitz, Dieter Haeussinger, Wolfram Trudo Knoefel, Verena Keitel, Irene Esposito
Published in: Cancers, 13/1, 2021, Page(s) 39, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010039

Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms

Author(s): Lucia Sarcina, Luisa Torsi, Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia
Published in: Sensors, 20/13, 2020, Page(s) 3678, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20133678

Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis

Author(s): Davide Blasi, Lucia Sarcina, Angelo Tricase, Angela Stefanachi, Francesco Leonetti, Domenico Alberga, Giuseppe Felice Mangiatordi, Kyriaki Manoli, Gaetano Scamarcio, Rosaria Anna Picca, Luisa Torsi
Published in: ACS Omega, 5/27, 2020, Page(s) 16762-16771, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.0c01717

New trends in single-molecule bioanalytical detection

Author(s): Eleonora Macchia, Kyriaki Manoli, Cincia Di Franco, Gaetano Scamarcio, Luisa Torsi
Published in: Analytical and Bioanalytical Chemistry, 412/21, 2020, Page(s) 5005-5014, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-020-02540-9

Standalone operation of an EGOFET for ultra-sensitive detection of HIV

Author(s): Sunil Kumar Sailapu, Eleonora Macchia, Irene Merino-Jimenez, Juan Pablo Esquivel, Lucia Sarcina, G. Scamarcio, Shelley D. Minteer, Luisa Torsi, Neus Sabaté
Published in: Biosensors and Bioelectronics, 156, 2020, Page(s) 112103, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2020.112103

Multiscale real time and high sensitivity ion detection with complementary organic electrochemical transistors amplifier

Author(s): Paolo Romele, Paschalis Gkoupidenis, Dimitrios A. Koutsouras, Katharina Lieberth, Zsolt M. Kovács-Vajna, Paul W. M. Blom, Fabrizio Torricelli
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17547-0

Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins

Author(s): Eleonora Macchia, Amber Tiwari, Kyriaki Manoli, Brigitte Holzer, Nicoletta Ditaranto, Rosaria Anna Picca, Nicola Cioffi, Cinzia Di Franco, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi
Published in: Chemistry of Materials, 31/17, 2018, Page(s) 6476-6483, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.8b04414

Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor

Author(s): Eleonora Macchia, Kyriaki Manoli, Brigitte Holzer, Cinzia Di Franco, Rosaria A. Picca, Nicola Cioffi, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi
Published in: Analytical and Bioanalytical Chemistry, 411/19, 2019, Page(s) 4899-4908, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-019-01778-2

A Study on the Stability of Water-Gated Organic Field-Effect-Transistors Based on a Commercial p-Type Polymer

Author(s): Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Angelo Tricase, Cinzia Di Franco, Gaetano Scamarcio, Nicola Cioffi, Luisa Torsi
Published in: Frontiers in Chemistry, 7, 2019, ISSN 2296-2646
Publisher: Frontiers Media S.A.
DOI: 10.3389/fchem.2019.00667

Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor

Author(s): Eleonora Macchia, Lucia Sarcina, Rosaria Anna Picca, Kyriaki Manoli, Cinzia Di Franco, Gaetano Scamarcio, Luisa Torsi
Published in: Analytical and Bioanalytical Chemistry, 412/4, 2020, Page(s) 811-818, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-019-02319-7

Ultimately Sensitive Organic Bioelectronic Transistor Sensors by Materials and Device Structures' Design

Author(s): Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Lucia Sarcina, Cinzia Di Franco, Nicola Cioffi, Davide Blasi, Ronald Österbacka, Fabrizio Torricelli, Gaetano Scamarcio, Luisa Torsi
Published in: Advanced Functional Materials, 2019, Page(s) 1904513, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201904513

Organic-based inverters: basic concepts, materials, novel architectures and applications

Author(s): Tim Leydecker, Zhiming M. Wang, Fabrizio Torricelli, Emanuele Orgiu
Published in: Chemical Society Reviews, 49/21, 2020, Page(s) 7627-7670, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00106f

A Rapidly Stabilizing Water-Gated Field-Effect Transistor Based on Printed Single-Walled Carbon Nanotubes for Biosensing Applications

Author(s): Alireza Molazemhosseini, Fabrizio Antonio Viola, Felix J. Berger, Nicolas F. Zorn, Jana Zaumseil, Mario Caironi
Published in: ACS Applied Electronic Materials, 3/7, 2021, Page(s) 3106-3113, ISSN 2637-6113
Publisher: ?
DOI: 10.1021/acsaelm.1c00332

Organic Field-Effect Transistor Platform for Label-Free, Single-Molecule Detection of Genomic Biomarkers

Author(s): Eleonora Macchia, Kyriaki Manoli, Cinzia Di Franco, Rosaria Anna Picca, Ronald Österbacka, Gerardo Palazzo, Fabrizio Torricelli, Gaetano Scamarcio, Luisa Torsi
Published in: ACS Sensors, 5/6, 2020, Page(s) 1822-1830, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.0c00694

Molecular analysis of cyst fluids improves the diagnostic accuracy of pre-operative assessment of pancreatic cystic lesions

Author(s): Lena Haeberle, Martin Schramm, Wolfgang Goering, Lisa Frohn, Caroline Driescher, Werner Hartwig, Hubert-Karl Preissinger-Heinzel, Torsten Beyna, Horst Neuhaus, Katharina Fuchs, Verena Keitel-Anselmino, Wolfram Trudo Knoefel, Irene Esposito
Published in: Scientific Reports, 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-81065-2

Ion buffering and interface charge enable high performance electronics with organic electrochemical transistors

Author(s): Paolo Romele, Matteo Ghittorelli, Zsolt Miklós Kovács-Vajna, Fabrizio Torricelli
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11073-4

Printed, cost-effective and stable poly(3-hexylthiophene) electrolyte-gated field-effect transistors

Author(s): Davide Blasi, Fabrizio Viola, Francesco Modena, Axel Luukkonen, Eleonora Macchia, Rosaria Anna Picca, Zahra Gounani, Amit Tewari, Ronald Österbacka, Mario Caironi, Zsolt M. Kovacs Vajna, Gaetano Scamarcio, Fabrizio Torricelli, Luisa Torsi
Published in: Journal of Materials Chemistry C, 8/43, 2020, Page(s) 15312-15321, ISSN 2050-7534
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tc03342a

Conference proceedings (12)

“Physical-based modeling of single-molecule label-free electrolyte-gated organic transistors”

Author(s): F. Torricelli, E. Macchia, K. Manoli, C. Di Franco, Z. M. Kovacs-Vajna, G. Palazzo, G. Scamarcio, L. Torsi
Published in: 2019, Page(s) Art. K.6.8
Publisher: International Conference on Advanced Materials

“Selective Single-Molecule Detection of clinically relevant biomarkers with an Organic Transistor”

Author(s): E. Macchia, R. A. Picca, N. Cioffi, C. Di Franco, G. Scamarcio, G. Palazzo, F. Torricelli, Ronald Österbacka, L. Torsi
Published in: 2019, Page(s) Art. K.6.2
Publisher: International Conference on Advanced Materials

Enhanced multifunctional bioelectronics with integrated organic electrochemical transistor architectures

Author(s): Fabrizio Torricelli
Published in: Integrated Sensors for Biological and Neural Sensing, 2021, Page(s) 13, ISBN 9781510641624
Publisher: SPIE
DOI: 10.1117/12.2583425

A label-free immunosensor based on a graphene water-gated field-effect transistor

Author(s): Rosaria Anna Picca, Davide Blasi, Eleonora Macchia, Kyriaki Manoli, Cinzia Di Franco, Gaetano Scamarcio, Fabrizio Torricelli, Amaia Zurutuza, Ilargi Napal, Alba Centeno, Luisa Torsi
Published in: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), 2019, Page(s) 136-138, ISBN 978-1-7281-0557-4
Publisher: IEEE
DOI: 10.1109/iwasi.2019.8791429

Effect of the ionic-strength of the gating-solution on a bioelectronic response

Author(s): Eleonora Macchia, Kyriaki Manoli, Brigitte Holtzer, Cinzia Di Franco, Fabrizio Torricelli, Rosaria Anna Picca, Gerardo Palazzo, Gaetano Scamarcio, Luisa Torsi
Published in: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), 2019, Page(s) 221-223, ISBN 978-1-7281-0557-4
Publisher: IEEE
DOI: 10.1109/iwasi.2019.8791318

Circuit Design and Design Automation for Printed Electronics

Author(s): M. Fattori, I.A. Fijn, L. Hu, E. Cantatore, F. Torricelli, M. Charbonneau
Published in: 2019 Design, Automation & Test in Europe Conference & Exhibition (DATE), 2019, Page(s) 42-47, ISBN 978-3-9819263-2-3
Publisher: IEEE
DOI: 10.23919/date.2019.8715095

Analysis of Label-Free Single-Molecule Biosensors based on Gate-Biofunctionalized Organic Transistors

Author(s): Fabrizio Torricelli, Eleonora Macchia, Kyriaki Manoli, Cinzia Di Franco, Zsolt M. Kovacs-Vajna, Gerardo Palazzo, Gaetano Scamarcio, Luisa Torsi
Published in: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), 2019, Page(s) 70-74, ISBN 978-1-7281-0557-4
Publisher: IEEE
DOI: 10.1109/iwasi.2019.8791380

Exploitation of cfDNA extracted from bile as liquid biopsy source in pancreatobiliary cancers

Author(s): C. Driescher, K. Ebner, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito
Published in: Virchows Archiv, 2019, Page(s) S62
Publisher: Springer

Case report: NGS of cell-free DNA from blood and bile as a follow-up strategy in a patient with metastatic pancreatic adenocarcinoma

Author(s): K. Ebner, C. Driescher, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito.
Published in: Virchows Archiv, 2019, Page(s) S235
Publisher: Springer

Investigation and Modelling of Single-Molecule Organic Transistors

Author(s): Fabrizio Torricelli, Eleonora Macchia, Paolo Romele, Kyriaki Manoli, Cinzia Di Franco, Zsolt M. Kovacs-Vajna, Gerardo Palazzo, Gaetano Scamarcio, Luisa Torsi
Published in: 2019 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD), 2019, Page(s) 1-4, ISBN 978-1-7281-0940-4
Publisher: IEEE
DOI: 10.1109/sispad.2019.8870484

Printed Smart Sensing Surfaces: technology, design and applications

Author(s): Marco Fattori, Joost A. Fijn, Enrico Genco, Eugenio Cantatore
Published in: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), 2019, Page(s) 1-1, ISBN 978-1-7281-0557-4
Publisher: IEEE
DOI: 10.1109/iwasi.2019.8791400

“Current-driven organic electrochemical transistor for bioelectronics applications”

Author(s): F. Torricelli
Published in: 2019
Publisher: United in innovation

Book chapters (2)

Organic Bioelectronic Transistors: From Fundamental Investigation of Bio-Interfaces to Highly Performing Biosensors

Author(s): E. Macchia, R. A. Picca, A. Tricase, C. Di Franco, A. Mallardi, N. Cioffi, G. Scamarcio, G.Palazzo, L.Torsi
Published in: Organic Bioelectronics for Life Science and Healthcare, 56, 2019, Page(s) 1-70, ISBN 9781-644900376
Publisher: Materials Research Forum LLC
DOI: 10.21741/9781644900376-1

Electronic and ionic transport in organic materials and devices

Author(s): Paolo Romele, Zsolt M. Kovács-Vajna, Fabrizio Torricelli
Published in: Organic Flexible Electronics, 2021, Page(s) 71-105, ISBN 9780128188903
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818890-3.00003-5