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Single molecule bio-electronic smart system array for clinical testing

Objective

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

H2020-ICT-2018-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE
Address
Via Della Lastruccia 3
50019 Firenze
Italy
Activity type
Research Organisations
EU contribution
€ 390 750

Participants (8)

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 415 765
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI BRESCIA
Italy
EU contribution
€ 391 221,25
Address
Piazza Mercato 15
25121 Brescia
Activity type
Higher or Secondary Education Establishments
ABO AKADEMI
Finland
EU contribution
€ 350 000
Address
Domkyrkotorget 3
20500 Abo
Activity type
Higher or Secondary Education Establishments
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 352 500
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 389 998,75
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
FLEXENABLE LIMITED
United Kingdom
EU contribution
€ 355 403,75
Address
34 Cambridge Science Park, Milton Road
CB4 0FX Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MASMEC SPA
Italy
EU contribution
€ 262 500
Address
Via Dei Gigli 21
70026 Modugno
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EFFICIENT INNOVATION SAS
France
EU contribution
€ 112 500
Address
Avenue Clement Ader 55
34170 Castelnau Le Lez
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)