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Screening of Gastric Cancer via Breath volatile organic compounds by Hybrid Sensing Approach

Objective

Gastric cancer has good chances to be cured if diagnosed at an early stage; currently, there is lack of a reliable non-invasive screening tool. Eastern Europe and Latin America are among the geographical areas with high burden of the disease.

This project is aiming at developing a non-invasive gastric cancer screening tool by detecting characteristic panels of volatile organic compounds (VOCs). The mechanisms of VOC origin and their composition in gastric cancer patients will be addressed via headspace analysis of cancer tissue, cell-lines, and bacterial flora; VOCs identified during this analysis will be compared to the compounds present in human breath, both via gas chromatography coupled to mass spectrometry (GC-MS).

Based on this data, a new type of breath analyser will be developed and validated building upon previously acquired expertise of the consortium members. Specifically, the exhaled breath analyser will combine electronic nose concepts utilizing gold nanoparticles and metal oxide sensors with orthogonal mid-infrared spectroscopic techniques for obtaining multi-dimensional analytical data sets; furthermore, compact pre-concentration schemes will be evaluated. All components will be integrated into several prototypes of portable and optimized devices.

The clinical studies will be conducted in parallel in European (Latvia, Ukraine) and Latin American (Colombia, Brazil, Chile) countries with high disease burden. Patients with gastric cancer and individuals with and without precancerous lesions (dysplasia, atrophy, intestinal metaplasia) will be enrolled. The role of confounding factors including H.pylori infection will be addressed.

As the main result, we expect to provide the first reliable non-invasive gastric cancer screening device based on exhaled breath analysis concepts for future large-scale implementation. The development of according research competences and international collaborations therefore is the most vital component of this project.

Field of science

  • /natural sciences/chemical sciences/organic chemistry/volatile organic compounds
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Address
Senate Building Technion City
32000 Haifa
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 650 363,75

Participants (11)

LATVIJAS UNIVERSITATE
Latvia
EU contribution
€ 510 000
Address
Rainis Boulevard 19
1586 Riga
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 466 250
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 253 727,50
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
JLM INNOVATION GMBH
Germany
EU contribution
€ 425 000
Address
Beethovenweg 41
72076 Tuebingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 395 535
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
HOSPITAL UNIVERSITARIO SAN IGNACIO
Colombia
EU contribution
€ 203 734,75
Address
Carrera 7 No 40-62, Piso2 Hospital Universitario San Ignacio
110231 Bogota
Activity type
Other
UNIVERSIDAD DE PAMPLONA
Colombia
EU contribution
€ 138 125
Address
Ciudad Universitaria Km 1 Via Bucaramanga
Pamplona
Activity type
Higher or Secondary Education Establishments
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile
EU contribution
€ 182 068,75
Address
Avenida Libertador Bernardo O'higgins 340
8331150 Santiago
Activity type
Higher or Secondary Education Establishments
FUNDACAO ANTONIO PRUDENTE
Brazil
EU contribution
€ 0
Address
Rua Prof Antonio Prudente 211
01509010 Sao Paulo
Activity type
Research Organisations
NATIONAL CANCER INSTITUTE
Ukraine
EU contribution
€ 197 500
Address
33/43 Lomonosova Street
03022 Kiyv
Activity type
Research Organisations
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
Finland
EU contribution
€ 358 875
Address
Tekniikantie 21
02150 Espoo
Activity type
Research Organisations