Screening of Gastric Cancer via Breath volatile organic compounds by Hybrid Sensing Approach

Livrables

VOC pattern of gastric juice will provide the headspace analysis results from gastric contents from patients with and without gastric cancer
First study tissue samples package including relevant approvals
Delivery of results obtained with three VOGAS analyzer prototypes during continuous field studies at clinical partner locations
Delivery of set of templates for reporting
Midterm recruitment report gastric cancer tissues by study site
Delivery of quality assurance plan will provide a report
VOC pattern of gastric tissues will provide the headspace analysis results from gastric cancer surgery tissue when compared to non-cancerous tissue

VOC pattern of gastric tissues will provide the headspace analysis results from gastric cancer surgerytissue when compared to noncancerous tissue

Delivery of the tools for implementation of collaborations will provide a report
VOC patterns of gastric cancer cell lines will provide the headspace analysis results from gastric cancer cell-lines

VOC patterns of gastric cancer cell lines will provide the headspace analysis results from gastric cancercelllines

VOC pattern of H. Pylori cultures will provide the headspace analysis results from H. Pylori culture

VOC pattern of H Pylori cultures will provide the headspace analysis results from H Pylori culture

Breath fingerprint results of gastric cancer based on the GC-MS analysis will be available to differentiate the fingerprint between the cancer and benign conditions

Breath fingerprint results of gastric cancer based on the GCMS analysis will be available to differentiate the fingerprint between the cancer and benign conditions

Report on status of posting results of the analytical analysis in study registries
Report on the pepsinogen testing results in plasma conducted to the groups of patients within WP5 and indicating the proportion of subjects with decreased pepsinogen levels

Delivery of optimized VOGAS prototype after field studies
Delivery of three VOGAS analyzer prototypes ready for in-field testing
Delivery of laboratory prototype of combined IR-iHWG-VOLGACORE sensor system
Delivery of the VOGAS instrument-to-instrument variability analysis

Project Web site

. Project Web site

Publications

In vitro profiling of volatile organic compounds released and consumed by CLS--145 and HGC--27 gastric cell lines

Auteurs: P. Mochalski, A. Leiherer, C. Heinzle, A. Muendlein, D. Ślefarska, L. Mezmale, I. Kikuste, I. Tolmanis, G. Shani, M. Leja, H. Haick
Publié dans: Helicobacter, Numéro e12750, 2020, Page(s) 55, ISSN 1523-5378
Éditeur: Wiley
DOI: 10.1111/hel.12745

Analysis of volatile organic compounds emitted by gastric juice

Auteurs: P. Mochalski, L. Mezmale, I. Polaka, I. Kikuste, A.Vanags, I. Tolmanis, V. Veliks, M. Leja
Publié dans: United European Gastroenterology Journal, Numéro 8, 2020, Page(s) 225, ISSN 2050-6414
Éditeur: United European Gastroenterology Journal
DOI: 10.1177/2050640620927345

VOC emission sampling from Helicobacter pylori cultures

Auteurs: R. Vangravs; D. Rudzīte; V. Veļiks; M. Leja; P. Mochalski
Publié dans: Helicobacter, Numéro e12647, 2019, Page(s) 127, ISSN 1523-5378
Éditeur: Wiley
DOI: 10.1111/hel.12647

Ex-vivo profiling of volatile organic compounds released from gastric cancer and non-cancerous tissue

Auteurs: Daria Slefarska, Linda Mezmale, Ilze Kikuste, Marcis Leja, Pawel Mochalski
Publié dans: Microbiota in Health and disease, Numéro e612, 2021, Page(s) 54, ISSN 2704-8845
Éditeur: EHMSG – 34th International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
DOI: 10.26355/mhd_20219_612

Identification of volatile organic compounds emitted by gastric juice

Auteurs: P. Mochalski, L. Mezmale, I. Polaka, I. Kikuste, A.Vanags, I. Tolmanis, V. Veliks, M. Leja
Publié dans: Helicobacter, Numéro e12750, 2020, Page(s) 49, ISSN 1523-5378
Éditeur: Wiley
DOI: 10.1111/hel.12745

Combined Chemoresistive and In Situ FTIR Spectroscopy Study of Nanoporous NiO films for Light-Activated Nitrogen Dioxide and Acetone Gas sensing

Auteurs: Katarzyna Drozdowska, Tesfalem Welearegay, Lars Österlund, Janusz Smulko
Publié dans: Sensors and Actuators B: Chemical, Numéro 353, 2022, Page(s) 131125, ISSN 0925-4005
Éditeur: Elsevier BV
DOI: 10.1016/j.snb.2021.131125

An Innovative Modular eNose System Based on a Unique Combination of Analog and Digital Metal Oxide Sensors.

Auteurs: Jaeschke, Carsten; Glöckler, Johannes; El Azizi, Oussama; Gonzalez, Oriol; Padilla, Marta; Mitrovics, Jan; Mizaikoff, Boris
Publié dans: ACS Sensors, Numéro 4, 2019, Page(s) 2277–2281, ISSN 2379-3694
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acssensors.9b01244

Characterization of metal oxide gas sensors via optical techniques

Auteurs: Johannes Glöckler, Carsten Jaeschke, Erhan Tütüncü, Vjekoslav Kokoric, Yusuf Kocaöz, Boris Mizaikoff
Publié dans: Analytical and Bioanalytical Chemistry, Numéro 412, 2020, Page(s) 4575-4584, ISSN 1618-2650
Éditeur: Springer Link
DOI: 10.1007/s00216-020-02705-6

From Light Pipes to Substrate-Integrated Hollow Waveguides for Gas Sensing: A Review

Auteurs: Diandra Nunes Barreto, Vjekoslav Kokoric, JoãoFlávio da Silveira Petruci, and Boris Mizaikof
Publié dans: ACS Measurement Science Au, Numéro 1, 2021, Page(s) 97-109, ISSN 2694-250X
Éditeur: American Chemical Society
DOI: 10.1021/acsmeasuresciau.1c00029

Sensing gastric cancer via point‐of‐care sensor breath analyzer

Auteurs: Leja, Marcis; Kortelainen, Juha M.; Polaka, Inese; Antikainen, Emmi; Mitrovics, J.; Padilla, M.; Mochalski, P.; Shuster, G.; Pohle, Roland; Kashanin, Dmitry; Klemm, Richard; Ikonen, Veikko; Mezmale, Linda; Broza, Yoav Y.; Shani, G.; Haick, Hossam
Publié dans: Leja , M , Kortelainen , J M , Polaka , I , Turppa , E , Mitrovics , J , Padilla , M , Mochalski , P , Shuster , G , Pohle , R , Kashanin , D , Klemm , R , Ikonen , V , Mezmale , L , Broza , Y Y , Shani , G & Haick , H 2021 , ' Sensing gastric cancer via point‐of‐care sensor breath analyzer ' , Cancer , vol. 127 , no. 8 , pp. 1286-1292 . https://doi.org/10.1002/cncr.33437, Numéro 2, 2021, Page(s) 1286-1292, ISSN 1097-0142
Éditeur: Cancer
DOI: 10.1002/cncr.33437

An eNose-based method performing drift correction for online VOC detection under dry and humid conditions

Auteurs: Carsten Jaeschke, Johannes Glöckler, Marta Padilla, Jan Mitrovics, Boris Mizaikoff
Publié dans: Analytical Methods, Numéro 12, 2020, Page(s) 4724-4733, ISSN 1759-9679
Éditeur: Royal society of chemistry
DOI: 10.1039/d0ay01172j

The Volatilomic Footprints of Human HGC-27 and CLS-145 Gastric Cancer Cell Lines

Auteurs: Andreas Leiherer, Daria Ślefarska, Marcis Leja, Christine Heinzle, Axel Mündlein, Ilze Kikuste, Linda Mezmale, Heinz Drexel, Chris A. Mayhew, Paweł Mochalski
Publié dans: Frontiers in Molecular Biosciences, Numéro 7, 2021, Page(s) 607904, ISSN 2296-889X
Éditeur: Frontiers in Molecular Biosciences
DOI: 10.3389/fmolb.2020.607904

Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies

Auteurs: Carsten Jaeschke, Marta Padilla, Johannes Glöckler, Inese Polaka, Martins Leja, Viktors Veliks, Jan Mitrovics, Marcis Leja, Boris Mizaikoff
Publié dans: Molecules, Numéro 3776, 2021, Page(s) 12, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26123776

iHWG-MOX: A Hybrid Breath Analysis System via the Combination of Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Metal Oxide Gas Sensors

Auteurs: Johannes Glöckler, Carsten Jaeschke, Yusuf Kocaöz, Vjekoslav Kokoric, Erhan Tütüncü, Jan Mitrovics, and Boris Mizaikoff
Publié dans: ACS Sensors, Numéro 5, 2020, Page(s) 1033-1039, ISSN 2379-3694
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acssensors.9b02554

Outside front cover: From Light Pipes to Substrate-Integrated Hollow Waveguides for Gas Sensing: A Review

How do international gastric cancer prevention guidelines influence clinical practice globally?

Auteurs: Evita Gasenko, Marcis Leja, Inese Polaka, Alinta Hegmane, Raul Murillo, Dmitry Bordin, Alexander Link, Minna Kulju, Pawel Mochalski, Gidi Shani, Peter Malfertheiner, Rolando Herrero, Hossam Haick
Publié dans: European Journal of Cancer Prevention, Numéro 29/5, 2020, Page(s) 400-407, ISSN 0959-8278
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/cej.0000000000000580

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation

Auteurs: Mamatha Serasanambati, Yoav Y. Broza, Hossam Haick
Publié dans: Advanced Biosystems, Numéro 3/10, 2019, Page(s) 1900131, ISSN 2366-7478
Éditeur: Wiley
DOI: 10.1002/adbi.201900131

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